Module number 1082




Database revision : gnsdb28.10
Date : Tue Feb 25 17:41:32 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond498:wtħ500nMaF,30minlog10(intensity)\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n mSWI5:transcriptional activator,transcriptional activator,homothal\nlic switching deficient\n Cond494:wtħ5nMaF,30minlog10(intensity)\n mTOS6:Hypothetical ORF,,\n mPDR16:involved in pleiotropic drug resistance by controlling lipid\ns in various cellular compartments; positively regulated by \nPDR1,Pdr17p homolog , Sec14p homolog,Null mutant is viable, \nexhibits hypersensitivity to azole inhibitors of ergosterol \nbiosynthesis, alterations in sterol composition of the plasm\na membrane; pdr16 pdr17 double deletion mutants exhibit addi\ntive exacerbated phenotypes\n Cond548:cln3-2\n Cond500:wtħ50nMaF,15minlog10(intensity)\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond504:wtħ50nMaF,90minlog10(intensity)\n mCLB5:role in DNA replication during S phase; additional functiona\nl role in formation of mitotic spindles along with Clb3 and \nClb4,B-type cyclin,Null mutant is viable, but has an extende\nd S phase\n mYBR070C:Unknown ,, Unknown\n mERG3:C-5 sterol desaturase,C-5 sterol desaturase,Null mutant is i\nnviable; suppresses syringomycin resistant mutant\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond519:rst1Drst2Dħ50nMaF,30minlog10(intensity)\n Calcin.NaNa:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond505:wtħ50nMaF,120minlog10(intensity)\n mYDR134C:Unknown ,, Unknown\n Cond507:bni1Dħ50nMaF,90minlog10(intensity)\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n mCTF18:Chromosome transmission,,Null mutant is viable, exhibits inc\nreased level of spontaneous mitotic recombination, slow grow\nth, and cold sensitivity\n Cond496:wtħ50nMaF,30minlog10(intensity)\n Cond805:Ca/Ca+FK30'\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mYKR077W:Unknown ,, Unknown\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n mYHP1:Hypothetical ORF,,\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n Cond807:crz1/Ca30'\n mMSH6:Required for mismatch repair in mitosis & meiosis, low level\ns of postmeiotic segregation & high spore viability; forms c\nomplex with Msh2p to repair both single-base & insertion-del\netion mispairs; redundant with Msh3p in repair of in-dels,hu\nman GTBP protein homolog,Null mutant is viable, msh3 msh6 do\nuble deletion mutants exhibit microsatellite instability and\n mutability similar to that in a msh2 mutant\n mFEN1:Involved in synthesis of 1,3-beta-glucan, a component of the\n cell wall, and elongation of fatty acids up to 24 carbons,1\n,3-beta-glucan synthase subunit (putative) , ELO1 homolog , \n1,3-beta-glucan synthase subunit (putative) , ELO1 homolog ,\n 1,3-beta-glucan synthase subunit (putative) , ELO1 homolog,\nNull mutant is viable; slow growth; fenpropimorph resistant;\n resistant to a pneumocandin B0 analog (L-733,560); mating a\nnd sporulation defects; synthetic lethality with ELO3\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond804:Ca/Ca+FK15'\n mYIL121W:Unknown ,, Unknown\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond734: mELO1:elongation enzyme 1, required for the elongation of the satu\nrated fatty acid tetradecanoic acid (14:0) to that of hexade\ncanoic acid (16:0),,Null mutant is viable, but shows no grow\nth on media supplemented with less than 16-C saturated fatty\n acid in a fatty acid synthase minus background\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n mYPL014W:Unknown ,, Unknown\n Cond806:crz1/Ca15'\n Cond816:Na/Na+FK30'\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n mHTA2:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2. Overexpression of TRT2 can s\nuppress Ty insertion mutations\n mSPO16:Early meiotic protein required for efficient spore formation\n,,sporulation defective\n Cond738:90\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYHR033W:Unknown ,, Unknown\n Cond742: Cond747: mSNL1:Suppressor of nup116-C lethal,18.3 kDa integral membrane pro\ntein,Null mutant is viable; SNL1 is a high copy suppressor o\nf nup116, gle2 and nic96 alleles\n Cond497:wtħ158nMaF,30minlog10(intensity)\n Calcin.crz1:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond493:wtħ1.5nMaF,30minlog10(intensity)\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n Cond503:wtħ50nMaF,60minlog10(intensity)\n Cond514:GAL-STE12,3hrs.gallog10(intensity)\n Cond510:fus3Dħ50nMaF,30minlog10(intensity)\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond551:alpha0\n mHTB2:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2\n
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Computational Genomics Lab, Tel-Aviv uniresity