Module number 1079




Database revision : gnsdb28.10
Date : Tue Feb 25 17:40:02 2003
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mYGR269W:Unknown ,, Unknown\n mMAF1:Mod5 protein sorting,,Mislocalizes Mod5p to the nucleus\n mVPS71:Unknown ,, Unknown\n mMET32:Involved in methionine metabolism,highly homologous to Met31\np , transcriptional regulator of sulfur amino acid metabolis\nm , zinc finger protein,the met31 met32 double mutant is a m\nethionine auxotroph\n mBNI4:bud neck involved,required to link Chs3p and Chs4p to the se\nptins,Null mutant is viable, shows delocalized chitin, elong\nated buds, enlarged bud necks\n mYOL083W:Unknown ,, Unknown\n mRBL2:binds to beta-tubulin and may participate in microtubule mor\nphogenesis,tubulin folding cofactor A,Overexpression rescues\n lethality caused by excess beta-tubulin\n mYBR287W:Unknown ,, Unknown\n mVPS74:Unknown ,, Unknown\n mCTP1:citrate transport protein,citrate tranporter,Null mutant is \nviable\n mPPM1:carboxy methyl transferase for protein phosphatase 2A cataly\ntic subunit,carboxy methyl transferase for protein phosphata\nse 2A catalytic subunit,Mutant is rapamycin resistant, benom\nyl supersensitive, and nocodazole sensitive.\n mPAD1:Phenylacrylic acid decarboxylase,phenylacrylic acid decarbox\nylase,Null mutant is viable but is cinnamic acid-sensitive\n mORM2:Unknown ,, Unknown\n mPUF4:member of the PUF protein family,,\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mFYV2:Function required for Yeast Viability on toxin exposure,,K1 \nkiller toxin hypersensitivity\n mYJR097W:Unknown ,, Unknown\n mMUP1:high affinity methionine permease,high affinity methionine p\nermease,Null mutant is viable but cannot perform high-affini\nty methionine update.\n mYNL200C:Unknown ,, Unknown\n mYDR179W-A:Unknown ,, Unknown\n mTAD1:Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala.,t\nRNA-specific adenosine deaminase subunit,Null mutant is viab\nle\n mWWM1:Unknown ,, Unknown\n mPEX11:May promote peroxisomal proliferation by participating in pe\nroxisomal elongation or fission or segregation of peroxisome\ns to daughter cells,peroxisomal membrane protein,Null mutant\n is viable but shows slower growth on oleate (or perhaps no \ngrowth at all), glycerol and acetate and has one or two very\n large peroxisomes; overexpression of PMP27 produces yeast w\nith an increased number of normal-sized peroxisomes\n mYPL107W:Unknown ,, Unknown\n mBUL2:a homologue of BUL1,,Null mutant is viable; the bul1 bul2 do\nuble disruptant is sensitive to various stresses\n mPST2:Protoplasts-SecreTed protein; the gene product was detected \namong the proteins secreted by regenerating protoplasts,,\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mNCR1:Niemann-Pick Type C homologous gene,transmembrane protein (p\nutative),Null mutant is viable.\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n mSMM1:Suppressor of Mitochondrial Mutation in the tRNAasp gene; Di\nhydrouridine synthase 2,tRNA dihydrouridine synthase,Overexp\nression weakly suppresses a mutation affecting the maturatio\nn of mitochondrial tRNA-Asp.\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mYER087W:Unknown ,, Unknown\n mARL1:Hydrolyzes GTP; myristylated; in soluble fraction,ADP-ribosy\nlation factor-like protein 1,Null mutant is viable\n mHOR2:RHR2 (GPP1) encodes another DL-glycerol-3-phosphatase,DL-gly\ncerol-3-phosphatase,\n mAMD1:putative alpha-mannosidase,alpha-mannosidase (putative),Null\n mutant is viable\n mVID24:also involved in vacuolar protein targeting,peripheral vesic\nle membrane protein,Null mutant is viable, defective in fruc\ntose-1,6-bisphosphatase dergadation\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mDFG5:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n mARL3:Similar to ADP-ribosylation factor,,Null mutant is viable, d\nisplays cold-sensitive growth\n mYOL085C:Unknown ,, Unknown\n mALG5:UDP-glucose:dolichyl-phosphate glucosyltransferase,UDP-gluco\nse:dolichyl-phosphate glucosyltransferase,underglycosylation\n of carboxypeptidase Y\n mYCL033C:Unknown ,, Unknown\n mRMD5:Unknown ,, Unknown\n mTAT2:Tryptophan permease, high affinity,tryptophan permease, high\n affinity,suppressor of chromosome segregation mutation\n mYJR142W:Unknown ,, Unknown\n mYKR100C:Unknown ,, Unknown\n mIES5:Ino Eighty Subunit 5,,Null: non essential.\n mCDC50:cell division cycle mutant,,Null mutant is cold-sensitive an\nd sensitive to MMS and HU\n mYMR029C:Unknown ,, Unknown\n mGIS2:GIG3 suppressor,,\n mCSM1:Hypothetical ORF,,missegregates chromosomes in meiosis\n mFAR3:Required for arrest in G1 in response to pheromone,,Null mut\nant does not arrest in G1 in response to pheromone but does \nhave an intact signal transduction pathway leading to FAR1 t\nranscriptional induction\n mLYS1:saccharopine dehydrogenase,,Lysine requiring\n mPYK2:Pyruvate kinase, glucose-repressed isoform,,Null mutant is v\niable and shows no obvious phenotypes; however, a pyk1 pyk2 \ndouble-deletion mutant shows growth defects more pronounced \nthan in the pyk1 mutant strain\n mPEX6:Required for peroxisome assembly,AAA ATPase,lack of peroxiso\nme biogenesis\n mYPR038W:Unknown ,, Unknown\n mYDL237W:Unknown ,, Unknown\n mLYS7:Involved in lysine biosynthesis, oxidative stress protection\n,copper chaperone for superoxide dismutase Sod1p,Null mutant\n is viable, methionine and lysine auxotroph, pH and temperat\nure sensitive; sensitive to superoxide generating drugs and \nlight irradiation, exhibits diminution of calcineurin activi\nty\n mCWC15:Unknown ,, Unknown\n mYAL053W:Unknown ,, Unknown\n mCOX17:Involved in copper metabolism and assembly of cytochrome oxi\ndase,cysteine-rich protein,Null mutant is viable, respirato\nry defective, rescued by addition of copper to growth media \nand/or high copy expression of SCO1 and SCO2 genes\n mLYS9:Seventh step in lysine biosynthesis pathway,,lysine auxotrop\nh\n mHBS1:Protein related to translation elongation factor EF-1alpha a\nnd to Suf12p/Sup2p/Gst1p/Sup35p,,\n mYDL172C:Unknown ,, Unknown\n mYBR071W:Unknown ,, Unknown\n mYLR137W:Unknown ,, Unknown\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mGCV2:Glycine CleaVage system,glycine cleavage system P subunit , \nglycine decarboxylase complex P subunit , glycine synthase P\n subunit,Inability to convert glycine to serine (ser1 backgr\nound); Inability to utilize glycine as a nitogen source.\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mSBP1:single stranded nucleic acid binding protein,,\n mYNL274C:Unknown ,, Unknown\n mYGR018C:Unknown ,, Unknown\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mYPL261C:Unknown ,, Unknown\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n mGPG1:Unknown ,, Unknown\n mYOL159C:Unknown ,, Unknown\n mYLR414C:Unknown ,, Unknown\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSDC1:YDR469W,,\n mYMR073C:Unknown ,, Unknown\n mPPH3:protein phosphatase type 2A,protein phosphatase type 2A,Null\n mutant is viable, pph3 pph21 pph22 mutants are inviable\n mGRX1:Glutaredoxin,glutaredoxin,Null mutant is viable but sensitiv\ne to oxidative stress. grx1 grx2 null mutants are viable but\n lack heat-stable oxidoreductase activity.\n mYBR174C:Unknown ,, Unknown\n mRDI1:Rho GDP dissociation inhibitor with activity toward Rho1p,,\n mARF2:ADP-ribosylation factor 2,ADP-ribosylation factor 2,Null mut\nant is viable\n mYPR039W:Unknown ,, Unknown\n mFCY21:identical to FCY2,purine-cytosine permease,\n mYCL049C:Unknown ,, Unknown\n mYOL093W:Unknown ,, Unknown\n mSBE22:functionally redundant and similar in structure to SBE2,,syn\nthetic lethal with sbe2 mutation\n mYGL051W:Unknown ,, Unknown\n mYPT10:similar to Rab proteins and other small GTP-binding proteins\n,,\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mLYS12:homo-isocitrate dehydrogenase, an NAD-linked mitochondrial e\nnzyme required for the fourth step in the biosynthesis of ly\nsine, in which homo-isocitrate is oxidatively decarboxylated\n to alpha-ketoadipate.,homo-isocitrate dehydrogenase,Null mu\ntant is viable but shows decreased growth in the absence of \nlysine\n mYBL012C:Unknown ,, Unknown\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mLGE1:Unknown ,, Unknown\n mYBL062W:Unknown ,, Unknown\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mSHG1:YBR258C,,\n mYGL226W:Unknown ,, Unknown\n mYOR300W:Unknown ,, Unknown\n mYNR009W:Unknown ,, Unknown\n mYKL069W:Unknown ,, Unknown\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n mARN1:Product of gene unknown,,\n mELA1:similar to mammalian elongin A, interacts with elongin C,elo\nngin A transcription elongation factor,viable\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mRCE1:Protease involved in ras and a-factor terminal proteolysis,p\nrotease,Null mutant is viable, has defects in Ras localizati\non and signaling, and suppresses the activated phenotype of \nthe RAS2val19 allele\n mNRG2:homologue of NRG1,NRG1 homolog,Null mutant is viable with no\n detected phenotypes\n mAZF1:probable transcription factor, asparagine-rich zinc-finger p\nrotein, suppressor of mutation in the nuclear gene for the c\nore subunit of mitochondrial RNA polymerase,,null mutant is \nviable\n mRGA2:contains a Rho-GAP domain and two LIM domains, similar to Rg\na1p and all known Rho-GAPs,Rho-GTPase Activating Protein,Nul\nl mutants are viable but increase the restrictive temperatur\ne of a cdc24-4 strain and increase the constitutive activati\non of the pheromone response pathway in conjungtion with mut\nations in RGA1 and BEM3; overexpression of RGA2 causes a dec\nrease in the restrictive temperature of a cdc42-1 strain\n mYDL050C:Unknown ,, Unknown\n mYDL057W:Unknown ,, Unknown\n mYNL319W:Unknown ,, Unknown\n mCIN2:involvement in microtubule function,tubulin folding cofactor\n C,Null mutant is viable but shows supersensitivity to benom\nyl and nocodazole, cold sensitivity, defects in karyogamy, a\nnd increased rates of chromosome loss; shows genetic interac\ntion with tubulin mutations\n mYMR030W:Unknown ,, Unknown\n mICL1:component of glyoxylate cycle,isocitrate lyase,Null mutant i\ns viable, fails to grow on ethanol as a carbon source\n mICL2:Isocitrate lyase, may be nonfunctional,isocitrate lyase, may\n be nonfunctional,Null mutant is viable\n mYDL173W:Unknown ,, Unknown\n mABP1:Actin binding protein,actin binding protein,Null mutant is v\niable\n mSAM2:methionine biosynthesis regulation,,Null mutant is viable\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n mPMC1:May be involved in depleting cytosol of Ca2+ ions,Ca2+ ATPas\ne (putative),Null mutant is viable but fails to grow in high\n Ca2+ medium; this death in high calcium is suppressed by mu\ntations in calcineurin (CNA1, CNA2, CNB1) and calmodulin (CM\nD1); pmc1 vcx1 double mutant is even more sensitive to Ca2+\n mLYS21:homocitrate synthase, highly homologous to YDL182W,YDL182W (\nLYS20) homolog , homocitrate synthase,\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYJL171C:Unknown ,, Unknown\n mAPM4:Clathrin associated protein, medium subunit,clathrin associa\nted protein complex medium subunit,\n mUIP3:Unknown ,, Unknown\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mMHT1:S-Methylmethionine:Homocysteine methylTransferase,,Does not \nuse S-methylmethionine as a sulfur source\n mYHR209W:Unknown ,, Unknown\n mEMP46:Unknown ,, Unknown\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mYPC1:Yeast Phyto-ceramidase,alkaline ceramidase with reverse acti\nvity,Null mutant is viable and two times more heat resistant\n than the wild-type parental strain.\n mYLR154C:Unknown ,, Unknown\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mMCM22:Required for maintenance of chromosomes and minichromosomes,\n,Null mutant is viable\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mYOR338W:Unknown ,, Unknown\n mTSA2:Unknown ,, Unknown\n mYEL059W:Unknown ,, Unknown\n mYIR014W:Unknown ,, Unknown\n mYDR112W:Unknown ,, Unknown\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mYBR220C:Unknown ,, Unknown\n mMSS1:May play a part in mitochondrial translation,GTPase (putativ\ne),respiratory deficient in presence of pr454 mutation in mi\ntochondrial 15S rRNA; block in splicing of mitochondrial int\nrons\n mZRG8:Zinc regulated gene,,\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n mPPR1:Positive regulator of URA1 and URA3,zinc finger transcriptio\nn factor of the Zn(2)-Cys(6) binuclear cluster domain type,N\null mutant is viable, deficient in pyrimidine biosynthetic p\nathway\n mYNL168C:Unknown ,, Unknown\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n mYSY6:Protein that participates in secretory pathway,,\n mYDL110C:Unknown ,, Unknown\n mYDL124W:Unknown ,, Unknown\n mSLT2:Suppressor of lyt2,,Null mutant is viable but temperature se\nnsitive. At elevated temperatures or in the presence of caff\neine, mull mutants exhibit cell wall defects that result in \ncell lysis. Lysis is prevented by addition of 1M sorbitol.\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mARA1:D-arabinose dehydrogenase,D-arabinose dehydrogenase,Null mut\nant is viable but cannot produce D-arabinono-1,4-lactone, a \nprecursor of D-erythroascorbic acid\n mRHO2:Gtp-binding protein of the rho subfamily of ras-like protein\ns,GTP-binding protein , rho subfamily,null is viable\n mYOR055W:Unknown ,, Unknown\n mOPI3:Second and third steps of methylation pathway for phosphatid\nylcholine biosynthesis,methylene-fatty-acyl-phospholipid syn\nthase (unsaturated phospholipid N-methyltransferase),Null mu\ntant is viable, temperature sensitive in the presence of mon\nomethylethanolamine, exhibits an inositol secretion phenotyp\ne\n mMET16:3'phosphoadenylylsulfate reductase,3'phosphoadenylylsulfate \nreductase,Null mutant is viable, and is a methionine auxotro\nph\n mFUI1:uridine permease,uridine permease,Null mutant is viable, res\nistant to 5-fluorouridine and does not grow on media contain\ning uridine as the sole source of pyrimidines\n mYCR076C:Unknown ,, Unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYOL046C:Unknown ,, Unknown\n mERP3:Emp24p/Erv25p related protein 2,p24 protein involved in memb\nrane trafficking,viable\n mALD2:Expression induced in response to high osmotic stress. NAD+ \nis preferred coenzyme.,aldeyhde dehydrogenase,ald2 ald3 doub\nle mutants show reduced growth rate with ethanol as the sole\n carbon source.\n mALD3:Expression induced in response to heat shock, oxidative and \nosmotic stress. NAD+ is preferred coenzyme.,aldehyde dehydro\ngenase,ald2 ald3 double mutants show reduced growth rate wit\nh ethanol as the sole carbon source.\n mYDR287W:Unknown ,, Unknown\n mHMF1:Homologous Mmf1p factor,,Null mutant grows faster than wild-\ntype cells and has higher survival rate at 42.5c; overexpres\nsion inhibits cell growth\n mYLR271W:Unknown ,, Unknown\n mCEM1:homology with beta-keto-acyl synthases,beta-keto-acyl syntha\nse homolog,Null mutant is viable; exhibits respiratory-defic\nient growth\n mSNO2:SNZ2 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable.\n mIDS2:IME2-Dependent Signalling,,Null mutations reduce or abolish \nthe ability of IME2p to activate expression of early, middle\n, and late meiotic genes. Recessive and null ids2 mutants pr\nevent toxicity of Ime2p expression in rad52 haploids, but do\n not affect Ime2p polypeptide accumulation.\n Cond803:CaFK60'\n Cond799:Ca60'\n mVTC1:Null mutant identified in different genetic screens both by \nits ability to reverse the Cdc42p suppression of a cdc24-4ts\n mutant and its ability to suppress the vacuolar ATPase null\n phenotype,S. pombe Nrf1p homolog (97% identical in predicte\nd amino acid sequence),Null mutant is viable, but exhibits b\noth reduced V-ATPase in the vacuolar membrane and reduced H(\n+)-ATPase(Pma1p) in the plasma membrane\n mLYP1:lysine permease,lysine permease,\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mCOX5B:Cytochrome-c oxidase chain Vb,cytochrome c oxidase chain Vb,\nNull mutant is viable\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mPCL2:Interacts with cyclin-dependent kinase PHO85 to form kinase \ncomplex with G1-periodic activity involved in cell cycle pro\ngression,G1 cyclin,\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mYHR087W:Unknown ,, Unknown\n mYOR325W:Unknown ,, Unknown\n mPLP1:Phosducin-Like Protein,,Null mutant is viable\n mAUA1:Involved in ammonia regulation of GAP1 activity,,Null mutant\n is viable\n mRGS2:Regulator of G-protein Signalling for gpa2; belongs to the R\nGS protein family and acts on Gpa2,GTPase activating protein\n (GAP),Null mutant is viable but exhibits high PKA phenotype\ns (low trehalose and glycogen levels, heat sensitivity, low \nexpression of HSP12). Overexpression results in low PKA phen\notypes and suppresses the glucose induced cAMP signal.\n mYPR064W:Unknown ,, Unknown\n mYPL170W:Unknown ,, Unknown\n mDUN1:DNA damage response,protein kinase,Null mutant is viable, de\nfective in DNA damage repair and in DNA damage-resposive ind\nuction of RNR genes, and sensitive to DNA damaging agents\n mYER028C:Unknown ,, Unknown\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mYER071C:Unknown ,, Unknown\n mKRE2:N-glycosylation,alpha-1,2-mannosyltransferase,have altered N\n-linked glycosylation of proteins and grow slowly at 30 degr\nees; unable to grow at 37 degrees\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mPHO13:p-nitrophenyl phosphatase,p-nitrophenyl phosphatase,Null mut\nant is viable\n mSUR2:Suppressor of rvs161 and rvs167 mutations,sphingosine hydrox\nylase,Null mutant is viable, has altered phospholipid levels\n mYMR099C:Unknown ,, Unknown\n mCUE1:Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cyto\nsolic surface of the endoplasmic reticulum. Assembly with Cu\ne1p is a prerequisite for the function of Ubc7p,Ubc7p bindin\ng and recruitment protein,Null mutant is viable and shows st\nabilization of ER degradation substrates\n mDSE3:Hypothetical ORF,,\n mMEI4:Functions in early recombination,88 bp intron at 5' end spli\nced independently of MER1 , meiosis-specific protein,Loss of\n full chromosome pairing, heteroduplex DNA, synaptonemal com\nplexes, meiotic intra- and interchromosomal gene conversion,\n reciprocal recombination and viable spores. mei4 executes b\noth divisions with a delay in meiosis II, is rescued by spo1\n3 and is epiststic to rad52\n mYGL157W:Unknown ,, Unknown\n mYOR289W:Unknown ,, Unknown\n mYBR062C:Unknown ,, Unknown\n mGSC2:Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundan\nt catalytic components of 1,3-beta-glucan synthase. Deletion\n of both is lethal,1,3-beta-D-glucan synthase catalytic comp\nonent,Null mutant is viable and shows partially reduced 1,3-\nbeta-glucan synthase activity\n mSGN1:contains one RNA recognition (RRM) domain,,\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mCSM1 mTAT2 mDSE3 mSDC1 mIMD3 mELA1 mSLT2 mLYS12
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Computational Genomics Lab, Tel-Aviv uniresity