Module number 1078




Database revision : gnsdb28.10
Date : Tue Feb 25 17:39:56 2003
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mTEC1:transcription factor of the TEA/ATTS DNA-binding domain fami\nly, regulator of Ty1 expression,TEA/ATTS DNA-binding domain \nfamily, regulator of Ty1 expression , transcription factor,N\null mutant is viable\n mVAC8:An armadillo repeat-containing protein localized on the vacu\nolar membrane,armadillo repeat-containing protein,Defective \nin vacuole inheritance and aminopeptidase I targeting to the\n vacuole\n mNOP4:RNA recognition motif-containing protein,RNA binding protein\n (putative),Null mutant is inviable; conditional mutant show\ns diminished accumulation of 60S ribosomal subunits due to a\n lack of production of mature 25S rRNA from 27S precursor rR\nNA\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n mLYS20:homocitrate synthase, highly homologous to YDL131W,YDL131W (\nLYS21) homolog , homocitrate synthase,Null mutant is viable,\n is able to grow on minimal media, and exhibits reduced but \nsignificant homocitrate synthase activity\n mLYS21:homocitrate synthase, highly homologous to YDL182W,YDL182W (\nLYS20) homolog , homocitrate synthase,\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n Cond711:t2+Vec\n mEGT2:cell-cycle regulation protein, may be involved in the correc\nt timing of cell separation after cytokinesis,,\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mHRP1:Putative polyadenylated-RNA-binding protein located in nucle\nus; similar to vertebrate hnRNP A/B protein family,,Null mut\nant is inviable; mutants can suppress temperature-sensitive \nalleles of npl3 (but not npl3 null mutants)\n mYBR139W:Unknown ,, Unknown\n mPBI2:Proteinase inhibitor that inhibits protease Prb1p (yscB),pro\nteinase inhibitor I2B (PBI2),Null mutant is viable but shows\n 50% elevation of protein degradation rate when cells are su\nbject to nutritional stress\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n Cond719:t4-SSD1\n Cond724:t4+SSD1,H44\n mDNF2:Drs2 Neo1 Family,Potential aminophospholipid translocase,via\nble\n mLSM5:Like Sm-E protein,snRNP protein,Null mutant is viable.\n Cond713:t4+Vec\n mYOR338W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mADO1:adenosine kinase,adenosine kinase,\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond718:t4+SSD1wt\n mYOR385W:Unknown ,, Unknown\n mSAC1:integral membrane protein localizing to the ER and Golgi,int\negral membrane protein,suppressor of actin mutations, suppre\nssor of sec14 alleles, inositol auxotrophy\n Cond722:t2+SSD1,H44\n mYPR114W:Unknown ,, Unknown\n Cond709:t0+Vec\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mCHO2:First step in the methylation pathway for phosphatidylcholin\ne biosynthesis,phosphatidyl-ethanolamine N-methyltransferase\n,Null mutant is viable and accumulates phosphatidylethanolam\nine and has reduced levels of phosphatidylcholine\n mYDL237W:Unknown ,, Unknown\n Cond717:t2-SSD1\n Cond716:t2+SSD1wt\n mCYK3:involved in CYtoKinesis,,Null mutant is viable, exhibits slo\nw growth, mild cytokinesis defects, and aberrant mother-bud \nneck morphology. cyk3/hof1 and cyk3/myo1 double mutants are\n inviable\n Cond725:t4-SSD1,M31\n Cond708:t0+SSD1\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n mYIL121W:Unknown ,, Unknown\n mGCV2:Glycine CleaVage system,glycine cleavage system P subunit , \nglycine decarboxylase complex P subunit , glycine synthase P\n subunit,Inability to convert glycine to serine (ser1 backgr\nound); Inability to utilize glycine as a nitogen source.\n mPDE1:3',5'-Cyclic-nucleotide phosphodiesterase, low affinity,3',5\n'-cyclic-nucleotide phosphodiesterase, low affinity,Null mut\nant is viable\n mNCL1:Nuclear protein 1, similar to NOP2 and human proliferation a\nssociated nucleolar protein p120,tRNA:m5C-methyltransferase,\nNull mutant is viable, sensitive to paromomycin, lacks m5C m\nethylation in total yeast tRNA\n Cond803:CaFK60'\n mYGP1:may be involved in cellular adaptations prior to stationary \nphase,gp37, a glycoprotein synthesized in response to nutrie\nnt limitation which is homologous to the sporulation-specifi\nc SPS100 gene,\n mVTC1:Null mutant identified in different genetic screens both by \nits ability to reverse the Cdc42p suppression of a cdc24-4ts\n mutant and its ability to suppress the vacuolar ATPase null\n phenotype,S. pombe Nrf1p homolog (97% identical in predicte\nd amino acid sequence),Null mutant is viable, but exhibits b\noth reduced V-ATPase in the vacuolar membrane and reduced H(\n+)-ATPase(Pma1p) in the plasma membrane\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mLYP1:lysine permease,lysine permease,\n mIRA2:Negatively regulates cAPK by antagonizing CDC25,GTPase activ\nating protein , highly homologous to Ira1p , neurofibromin h\nomolog , GTPase activating protein , highly homologous to Ir\na1p , neurofibromin homolog,Null mutant is viable, exhibits \nincreased sensitivity to heat shock and nitrogen starvation,\n sporulation defects, and suppression of the lethality of a \ncdc25 mutants\n mUBP6:deubiquitinating enzyme (putative),,\n Cond723:t2-SSD1,M31\n mYBR293W:Unknown ,, Unknown\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mTRM5:tRNA modification enzyme,,\n mPCL5:PHO85 cyclin,,Null mutant is viable.\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n mGCD1:general control of amino acid biosynthesis and cell cycle in\nitiation,gamma subunit , negative regulator in the general c\nontrol of amino acid biosynthesis , translation initiation f\nactor eIF2B subunit,affect growth rate under nonstarvation c\nonditions\n mYPL229W:Unknown ,, Unknown\n mSUR2:Suppressor of rvs161 and rvs167 mutations,sphingosine hydrox\nylase,Null mutant is viable, has altered phospholipid levels\n mBAT1:branched-chain amino acid transaminase, highly similar to ma\nmmalian ECA39, which is regulated by the oncogene myc,branch\ned-chain amino acid transaminase , highly similar to mammali\nan ECA39, which is regulated by the oncogene myc , branched-\nchain amino acid transaminase , highly similar to mammalian \nECA39, which is regulated by the oncogene myc,Null mutant is\n viable; ILV auxotrophy in bat1 bat2 double mutant\n Cond721:t0-SSD1,M31\n mSRL1:Suppressor of rad53 lethality,,\n mATP16:ATP synthase delta subunit,ATP synthase delta subunit,cells \nare entirely cytoplasmic petite\n Cond710:t2+SSD1\n mCCT2:cytoplasmic chaperonin of the Cct ring complex related to Tc\np1p; subunit beta,,Null mutant is inviable; some mutant alle\nles exhibit defects in microtubule and actin assembly.\n mMXR1:peptide Methionine sulfoXide Reductase 1,peptide methionine \nsulfoxide reductase,Null mutant is viable; shows weaker grow\nth on methionine sulfoxide as only sulfur source, increased \nresistance to ethionine sulfoxide, and inability to form dim\nethylsulfide (DMS) from dimethylsulfoxide (DMSO).\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n
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Computational Genomics Lab, Tel-Aviv uniresity