Module number 1072




Database revision : gnsdb28.10
Date : Tue Feb 25 17:39:17 2003
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mYMR316C-A:Unknown ,, Unknown\n mYGL165C:Unknown ,, Unknown\n Cond796:Ca5'\n mFMS1:Multicopy suppressor of fenpropimorph resistance (fen2 mutan\nt), shows similarity to Candida albicans corticosteroid-bind\ning protein CBP1,putatitive amine oxidase,Null mutant is via\nble\n mPEP12:integral membrane protein; c-terminal TMD; located in endoso\nme,c-terminal TMD , integral membrane protein , c-terminal T\nMD , integral membrane protein , c-terminal TMD , integral m\nembrane protein,proteinase deficient\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYBR287W:Unknown ,, Unknown\n mYNR064C:Unknown ,, Unknown\n Cond221:yer083c\n mSIA1:Unknown ,, Unknown\n Cond798:Ca30'\n mYMR107W:Unknown ,, Unknown\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n Cond121:qcr2(haploid)\n mSTE13:dipeptidyl aminopeptidase,dipeptidyl aminopeptidase,Null mut\nant is viable, sporulation proficient\n Cond362:dtt_000_min__dtt-2\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYDR391C:Unknown ,, Unknown\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCVT19:Cytoplasm to Vacuole Targeting; Mutant is defective in impor\nt of aminopeptidase I through the cytoplasm to vacuole targe\nting pathway,Receptor for biosynthetic cytoplasm to vacuole \ntargeting,Null: viable, unable to target vacuolar aminopepti\ndase I and to vacuoles, both under growing and nitrogen star\nvation conditions.\n Calcin.NaNa:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYBR005W:Unknown ,, Unknown\n Cond505:wtħ50nMaF,120minlog10(intensity)\n mYPR197C:Unknown ,, Unknown\n mYGR212W:Unknown ,, Unknown\n mYLR194C:Unknown ,, Unknown\n Cond805:Ca/Ca+FK30'\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mAMS1:vacuolar alpha mannosidase,alpha mannosidase,null mutant is \nviable\n mCRH1:congo red hypersensitive,cell wall protein,Null mutant is vi\nable and hypersensitive to Congo Red and Calcofluor White\n mYHR097C:Unknown ,, Unknown\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mDFG5:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n mYOR385W:Unknown ,, Unknown\n Cond817:Na/Na+FK45'\n Cond155:she4\n mYCR007C:Unknown ,, Unknown\n Cond279:ERG11(tetpromoter)\n mDDR48:DNA damage inducible; implicated in the production or recove\nry of mutations,contains >35 repeats of the amino acid seque\nnce NNNDSYGS , flocculent specific protein,Null mutant is vi\nable, displays reduced spontaneous mutation rate\n mYJL016W:Unknown ,, Unknown\n mYNL208W:Unknown ,, Unknown\n mENA1:Plasma membrane Na+ pump; P-type ATPase,P-type ATPase Na+ pu\nmp , plasma membrane ATPase , P-type ATPase Na+ pump , plasm\na membrane ATPase,Null mutant is sensitive to Na+\n mENA2:plasma membrane protein; putative Na+ pump; P-type ATPase,P-\ntype ATPase Na+ pump , plasma membrane ATPase , plasma membr\nane protein,Null mutant is viable and sensitive to Na+, Li+,\n and alkaline pH\n Cond807:crz1/Ca30'\n mENA5:Na(+) ATPase,Na+ ATPase,\n Cond804:Ca/Ca+FK15'\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond797:Ca15'\n Cond367:dtt_240_min_dtt-2\n mYMR007W:Unknown ,, Unknown\n mYAL053W:Unknown ,, Unknown\n mSNZ1:Snooze: stationary phase-induced gene family; may be involve\nd in cellular response to nutrient limitation and growth arr\nest,highly conserved 35 kDa protein that shows increased exp\nression after entry into stationary phase,Null mutant is via\nble, sensitive to 6-azauracil and methylene blue.\n mSSD1:Product of gene unknown,,Suppressor of regulatory subunit of\n protein kinase\n Cond818:crz1/Na30'\n mBOP1:bypass of PAM1,,\n Cond68:gas1\n Cond816:Na/Na+FK30'\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n mYLR414C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond819:crz1/Na45'_\n mSPS100:involved in spore development,sporulation-specific cell wall\n maturation protein,Null mutant is viable.\n mYLR327C:Unknown ,, Unknown\n mENB1:Siderophore transporter for enterobactin; AFT1 regulon,enter\nobactin transporter,Null mutants are viable but are unable t\no take up and utilize iron from enterobactin\n Cond691:gal5+gal\n mYBR203W:Unknown ,, Unknown\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mCUP2:Upregulates metallothionein (CUP1) expression in response to\n Cu2+,transcriptional activator,Null mutant is sensitive to \nCu2+\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n Cond366:dtt_120_min_dtt-2\n mNPT1:homology to bacterial nicotinate phosphoribosyl transferase,\n,\n Calcin.crz1:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYOR220W:Unknown ,, Unknown\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYER184C:Unknown ,, Unknown\n mYMR294W-A:Unknown ,, Unknown\n mTHI4:Protein highly expressed in early stationary phase during gr\nowth on molasses,biosynthetic pathway component producing th\ne thiazole precursor of thiamine,Null mutant is viable, auxo\ntrophic for thiamine\n mYNL043C:Unknown ,, Unknown\n mVPS36:Defective in vacuolar protein sorting,,\n mKHA1:putative K+/H+ antiporter,,\n Cond281:HMG2(tetpromoter)\n mRTA1:involved in 7-aminocholesterol resistance,,Null mutant is vi\nable; overexpression confers resistance to 7-aminocholestero\nl\n mPMC1:May be involved in depleting cytosol of Ca2+ ions,Ca2+ ATPas\ne (putative),Null mutant is viable but fails to grow in high\n Ca2+ medium; this death in high calcium is suppressed by mu\ntations in calcineurin (CNA1, CNA2, CNB1) and calmodulin (CM\nD1); pmc1 vcx1 double mutant is even more sensitive to Ca2+\n mDIA1:may be involved in invasive growth, pseudohyphal growth,,Nul\nl mutant is viable and causes invasive growth in haploids an\nd pseudohyphal growth in diploids\n Cond887:t-BuOOH\n mYJL171C:Unknown ,, Unknown\n mUIP3:Unknown ,, Unknown\n Cond363:dtt_015_min_dtt-2\n mYHR209W:Unknown ,, Unknown\n Cond504:wtħ50nMaF,90minlog10(intensity)\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mYIP3:Interacts with YPT proteins,,\n Cond375:1.5_mM_diamide_(60_min)\n Cond384:Hypo-osmotic_shock_-_5_min\n Cond53:erg2\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCMK2:Calmodulin-dependent protein kinase,calmodulin-dependent pro\ntein kinase,Null mutant is viable, exhibits slow rate of spo\nre germination\n mYPK1:76.5 kDa Serine/threonine protein kinase with similarity to \nprotein kinase C, is 90% identical to Ypk2p,76.5 kDa serine/\nthreonine protein kinase , similarity to protein kinase C, i\ns 90% identical to Ypk2p,Null mutant is viable, slow growing\n, ypk1 ypk2 double deletion mutants are defective for vegeta\ntive growth\n mRCN1:Regulator of calcineurin,calcineurin inhibitor,Overexpressio\nn phenotype: decreased calcineurin function\n mYER185W:Unknown ,, Unknown\n Cond532:GAL-RHO1-Q68H,3hrs.gallog10(intensity)\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n mSLT2:Suppressor of lyt2,,Null mutant is viable but temperature se\nnsitive. At elevated temperatures or in the presence of caff\neine, mull mutants exhibit cell wall defects that result in \ncell lysis. Lysis is prevented by addition of 1M sorbitol.\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYPS1:Gpi-anchored aspartic protease (Yapsin 1),GPI-anchored aspar\ntic protease,Null mutant is viable, defective in expression \nof somatostatin-28; yps1 mkc7 double disruptants are tempera\nture sensitive; yps1 mkc7 kex2 mutants are profoundly temper\nature sensitive and are cold sensitive\n mYPS3:Gpi-anchored aspartic protease (Yapsin 3),GPI-anchored aspar\ntic protease,Null mutant is viable\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mBAG7:Structural homolog of SAC7,GTPase activating protein (GAP),N\null mutant is viable; overexpression suppresses sac7 null mu\ntation\n mYHR138C:Unknown ,, Unknown\n mMET14:adenylylsulfate kinase,adenylylsulfate kinase,Null mutant is\n viable, and is a methionine auxotroph\n mAPG5:Involved in autophagy,,reduced viability upon nutrient starv\nation; defective in autophagy\n mCHS1:disrupts mating and sporulation efficiently,chitin synthase \n1,Null mutant is viable\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYGR268C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mYGR043C:Unknown ,, Unknown\n mPRM4:pheromone-regulated membrane protein,,\n mPRM8:pheromone-regulated membrane protein,,\n mPRM9:pheromone-regulated membrane protein,,\n Cond799:Ca60'\n Cond806:crz1/Ca15'\n mUBP5:Putative Ubiquitin-specific protease,ubiquitin-specific prot\nease (putative),Null mutant is viable\n mCPS1:carboxypeptidase yscS,carboxypeptidase yscS,Null mutant is v\niable; leucine auxotroph\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mMEP1:ammonia permease,ammonia permease,\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n mYMR040W:Unknown ,, Unknown\n mNGL3:DNase/RNase (putative); CCR4 C-terminal homolog; displays ho\nmology to drosophila Angel gene; homolog to ngl1 and ngl2,DN\nase (putative) , RNase (putative),\n Cond294:Itraconazole\n mMNT4:MaNnosylTransferase,mannosyltransferase (putative),\n mYBR004C:Unknown ,, Unknown\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mKRE6:cell wall beta-glucan assembly,beta-glucan synthase (putativ\ne),Null mutant is viable, slow growing, killer toxin-resista\nnt, possesses half the normal level of wild-type cell wall (\n1-->6) beta-glucan)\n mYMR295C:Unknown ,, Unknown\n mYMR251W:Unknown ,, Unknown\n Cond299:Tunicamycin\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mYIL108W:Unknown ,, Unknown\n mPHM7:Hypothetical ORF,,transcription is regulated by PHO system\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYOR289W:Unknown ,, Unknown\n mGSC2:Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundan\nt catalytic components of 1,3-beta-glucan synthase. Deletion\n of both is lethal,1,3-beta-D-glucan synthase catalytic comp\nonent,Null mutant is viable and shows partially reduced 1,3-\nbeta-glucan synthase activity\n mPTP2:protein tyrosine phosphatase,tyrosine phosphatase,Null mutan\nt is viable, grows slowly, is hypersensitive to heat; ptp2 p\ntc1 mutants exhibit synthetic lethality\n mHAL5:Protein kinase homolog, mutant is salt and pH sensitive,,\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mCUP2 mYOR220W mSLT2
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Computational Genomics Lab, Tel-Aviv uniresity