Module number 1067




Database revision : gnsdb28.10
Date : Tue Feb 25 17:38:50 2003
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mDBF2:kinase required for late nuclear division,,Null mutant is vi\nable, dbf1 dbf20 null mutants are inviable; mutants show dum\nb-bell phenotype\n mHST3:Homolog of SIR2,,hst3 hst4 double mutant has defects in telo\nmeric silencing, cell cycle progression, radiation resistanc\ne, and genomic stability\n mHST4:Homolog of SIR2,,hst3 hst4 double mutant has defects in telo\nmeric silencing, cell cycle progression, radiation resistanc\ne, and genomic stability\n mSWI5:transcriptional activator,transcriptional activator,homothal\nlic switching deficient\n Cond565:alpha98\n Cond798:Ca30'\n Cond548:cln3-2\n Cond578:cdc15_130\n mASH1:Zinc-finger inhibitor of HO transcription which is asymmetri\ncally localized to the daughter cell nucleus,,Mutant ash1 da\nughters can transcribe HO and switch mating type\n mGPA1:Involved in the mating pheromone signal transduction pathway\n; component of pheromone response pathway common to both a a\nnd alpha cells.,G protein alpha subunit , coupled to mating \nfactor receptor , G protein alpha subunit , coupled to matin\ng factor receptor , G protein alpha subunit , coupled to mat\ning factor receptor,The null mutation is inviable in haploid\ns but not diploids. Gpa1 mutants exhibit specific defects in\n the pheromone responsiveness of both a and alpha cells.\n mYNL058C:Unknown ,, Unknown\n mYMR031C:Unknown ,, Unknown\n Cond751: mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mBUD4:co-assembles with Bud3p at bud sites,,Null mutant is viable,\n haploids have dipolar budding, normally they have axial bud\nding, no effects on diploids\n mEGT2:cell-cycle regulation protein, may be involved in the correc\nt timing of cell separation after cytokinesis,,\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mCLB2:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb1 mutation)\n Cond735: mYML119W:Unknown ,, Unknown\n mHOF1:SH3 domain containing-protein required for cytokinesis,,Null\n mutant is defective in cytokinesis\n mNIS1:Hypothetical ORF,,\n Cond556:alpha35\n Cond561:alpha70\n mYJL051W:Unknown ,, Unknown\n mYPL158C:Unknown ,, Unknown\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond573:cdc15_80\n Cond586:cdc15_210\n mCDC5:CDC5 is dispensable for premeiotic DNA synthesis and recombi\nnation, but required for tripartite synaptonemal complexes, \nhaploidization, and spores,protein kinase,Null mutant is inv\niable. cdc5(ts) mutants form synaptonemal complexes lacking \ncentral elements and arrest either at meiosis I with broken \nspindles or at meiosis II with short spindles. Late shifts t\no a restrictive temperature result in reductional dyads; eac\nh spore contains an entire meiosis II short spindle with uns\neparated chromatids. In some strains at semi-permissive temp\nerature, chromosomes segregate reductionally or equationally\n depending upon the centromere.\n mCDC46:Member of complex that acts at ARS's to initiate replication\n,,Null mutant is inviable; at nonpermissive temperature cdc4\n6(ts) mutants arrest with a large bud and a single nucleus a\nnd exhibit a high rate of recombination\n mCDC47:Essential for initiation of DNA replication,,Null mutant is \ninviable, at nonpermissive temperature cdc47(ts) mutants arr\nest with a large bud and a single nucleus\n mKIN3:protein kinase,protein kinase,Null mutant is viable\n mNCE102:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mHSP150:Heat shock protein, secretory glycoprotein,heat shock protei\nn , secretory glycoprotein , heat shock protein , secretory \nglycoprotein , heat shock protein , secretory glycoprotein,N\null mutant is viable\n Cond562:alpha77\n Cond748: COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond530:GAL-BNI1D,3hrs.gallog10(intensity)\n Cond568:alpha119\n mYLR190W:Unknown ,, Unknown\n Cond753: mMCM2:Member of complex that acts at ARS's to initiate replication\n,,Null mutant is inviable, at nonpermissive temperature mcm2\n(ts) mutants arrest with a large bud and a single nucleus, w\nith < 2N DNA content, and exhibit a high rate of recombinati\non; mcm2 mutants are defective in minichromosome maintenance\n; mcm2-1 cdc45-1 mutants are synthetically lethal\n Cond279:ERG11(tetpromoter)\n mMCM3:Member of complex that acts at ARS's to initiate replication\n,,Null mutant is inviable, at nonpermissive temperature mcm3\n(ts) mutants arrest with a large bud and a single nucleus an\nd exhibit a high rate of recombination; mcm3 mutants are def\nective in minichromosome maintenance; mcm3-1 cdc45-1 mutants\n are synthetically lethal\n mPHO3:Acid phosphatase, constitutive,acid phosphatase,phosphatase \ndeficient\n Cond752: Cond588:cdc15_230\n mPHO5:Acid phosphatase, repressible,acid phosphatase,phosphatase d\neficient\n Cond508:bni1Dą50nMaF,120minlog10(intensity)\n Cond749: mFAR1:Factor arrest protein,Cdc28p kinase inhibitor,\n Cond550:clb2-1\n Cond557:alpha42\n mCDC54:essential for initiation of DNA replication; homolog of S. p\nombe CDC21,,Null mutant is inviable; at nonpermissive temper\nature cdc54(ts) mutants arrest with a large bud and a single\n nucleus and exhibit a high rate of recombination\n mYOR066W:Unknown ,, Unknown\n mMFA2:mating a-factor pheromone precursor,a-factor mating pheromon\ne precursor,\n mPMA1:major regulator of cytoplasmic pH,plasma membrane H+-ATPase,\ninviable; pma1 mutants are resistant to Dio-9, ethidium brom\nide and guanidine derivatives\n mCHS2:chitin synthase 2,chitin synthase 2,disruption results in lo\nss of well-defined septa and in growth arrest\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mYLR413W:Unknown ,, Unknown\n Cond572:cdc15_70\n Cond558:alpha49\n mCDC20:Required for onset of anaphase,anaphase promoting complex (A\nPC) subunit,Null mutant is inviable; conditional alleles sho\nw cell cycle arrest in G2\n mRME1:mediates cell type control of sporulation; negatively regula\ntes IME1 and sporulation,negative regulator of meiosis; dire\nctly repressed by a1-a2 regulator , zinc finger protein,Null\n mutant is viable, rme1 allows alpha/alpha and a/a diploids \nto sporulate, and a and alpha haploids to form viable spores\n in the presence of spo13\n mYGP1:may be involved in cellular adaptations prior to stationary \nphase,gp37, a glycoprotein synthesized in response to nutrie\nnt limitation which is homologous to the sporulation-specifi\nc SPS100 gene,\n mMRH1:Membrane protein related to Hsp30p; Localized by immunofluor\nescence to membranes, mainly the plasma membr. punctuate imm\nunofluorescence pattern observed in buds. The nuclear envelo\npe, but not vacuole or mitochondrial membranes also stained,\n,Null mutant is viable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond582:cdc15_170\n mTAF2:TATA binding protein-associated factor (TAF),TATA binding pr\notein-associated factor,Null mutant is inviable\n Cond554:alpha21\n Cond738:90\n Cond571:cdc15_50\n mPRY1:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mPHO11:Acid phosphatase, secreted,acid phosphatase,phosphatase defi\ncient\n mPHO12:acid phosphotase, nearly identical to Pho11p,acid phosphatas\ne,\n Cond560:alpha63\n Cond576:cdc15_110\n Cond555:alpha28\n mDSE4:Hypothetical ORF,,\n Cond570:cdc15_30\n Cond736: Cond511:GAL-STE4,3hrs.gallog10(intensity)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond559:alpha56\n mYRO2:Homolog to HSP30 heat shock protein Yro1p,,\n mMYO1:myosin class II,class II myosin,Null mutant is viable, exhib\nts abnormal chitin distribution and cell wall organization a\nt the mother-bud neck in a high proportion of dividing cells\n; exhibits abberant nuclear migration and cytokinesis; bem2 \nmyo1 double mutants are inviable\n Cond577:cdc15_120\n mYNL057W:Unknown ,, Unknown\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mPIR1:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) do\nuble mutant and pir1 hsp150 (pir2) pir3 triple mutant are sl\now-growing on agar slab and sensitive to heat shock\n Cond551:alpha0\n Cond549:clb2-2\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n mCDC47 mMCM3 mCDC46
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Computational Genomics Lab, Tel-Aviv uniresity