Module number 1062




Database revision : gnsdb28.10
Date : Tue Feb 25 17:38:16 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mGUT1:Glycerol utilization,converts glycerol to glycerol-3-phospha\nte , glyerol kinase,Null mutant is viable but is unable to g\nrow on glycerol\n mYPL201C:Unknown ,, Unknown\n mGAC1:Regulatory subunit for phosphoprotein phosphatase type 1 (PP\n-1), also known as Glc7p, which regulates glycogen synthase-\n2,Glc7p regulatory subunit,Reduced glycogen accumulation\n PEX.Pex:Transcriptome profiling to identify genes involved in peroxi\nsome assembly and function. J Cell Biol. 2002 Jul 22;158(2)\n:259-71.\n Cond698:gal3-gal\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSDH2:Succinate dehydrogenase (ubiquinone) iron-sulfur protein sub\nunit,succinate dehydrogenase (ubiquinone) iron-sulfur protei\nn subunit,Null mutant is viable\n mCTA1:catalase A,catalase A,Null mutant is viable and heat sensiti\nve\n Cond548:cln3-2\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mYMR107W:Unknown ,, Unknown\n Cond418:YPD_1_d_ypd-2\n mYAT2:The Yat2p protein shows significant homology with the known \ncarnitine acetyltransferase associated with the outer-mitoch\nondrial membrane, Yat1p, and also functions as a carnitine a\ncetyltransferase.,carnitine acetyltransferase,Null: viable. \nOther phenotypes: The cit2yat2 double mutant does not grow o\nn ethanol, glycerol and acetate in the presence of carnitine\n.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mFUN34:Highly homologous to Ycr010p and similar to Yarrowia lipolyt\nica glyoxylate pathway regulator GPR1 (see MIPS),transmembra\nne protein (putative),Null mutant is viable\n Cond400:Nitrogen_Depletion_12_h\n Cond697:gal2-gal\n mPBI2:Proteinase inhibitor that inhibits protease Prb1p (yscB),pro\nteinase inhibitor I2B (PBI2),Null mutant is viable but shows\n 50% elevation of protein degradation rate when cells are su\nbject to nutritional stress\n mCYB2:Expression is repressed by glucose and anaerobic conditions,\n is induced by L-lactate and is regulated by GRR1, ROX3, HAP\n1, HXK2 and CYC8,L-lactate cytochrome c oxidoreductase , cyt\nochrome b2,Null mutant is viable but is deficient in cytochr\nome b2 and L-lactate dehydrogenase activity and is unable to\n use L-lactate as a sole carbon source\n Cond467:steady_state_21_dec_C_ct-2\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond416:YPD_10_h__ypd-2\n mPOX1:fatty-acyl coenzyme A oxidase,fatty-acyl coenzyme A oxidase,\nNull mutant is viable, exhibits diminished ability to use ol\neic acid as a carbon source\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond911:(83i5)_S150-2B_YPD_NormInt\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYGR067C:Unknown ,, Unknown\n Cond454:YP_fructose_vs_reference_pool_car-2\n mSFC1:succinate-fumarate carrier,succinate-fumarate transport prot\nein,\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n mXBP1:DNA-binding transcriptional repressor,transcriptional repres\nsor,Null mutant is viable; overexpression of XBP1 leads to a\n slow-growth phenotype, lengthening of G1, an increase in ce\nll volume, and a repression of G1 cyclin expression\n Cond696:gal1-gal\n Cond310:Heat_Shock_000_minutes_hs-2\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond704:gal80-gal\n mCAT2:Carnitine O-acetyltransferase, peroxisomal and mitochondrial\n,carnitine O-acetyltransferase,Null mutant is viable; cat2 c\nit2 double mutants cannot grow on oleate.\n Cond701:gal6-gal\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond404:Nitrogen_Depletion_5_d\n Cond689:gal3+gal\n Cond915:(99i4)_HBY4_YPGL_NormInt\n Cond452:sucrose_vs._reference_pool_car-1\n Cond693:gal7+gal\n mRTN2:Unknown ,, Unknown\n Cond694:gal10+gal\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mGLC3:Glycogen branching enzyme,1,4-glucan-6-(1,4-glucano)-transfe\nrase,Null mutant is viable, glycogen deficient\n Cond700:gal5-gal\n mODC1:Oxodicarboxylate carrier,mitochondrial 2-oxodicarboxylate tr\nansport protein,\n Cond688:gal2+gal\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCIT3:Mitochondrial isoform of citrate synthase,citrate synthase,N\null mutant shows severely reduced growth on the respiratory \nsubstrate glycerol in a delta cit1 background\n Cond692:gal6+gal\n mACS1:one of 2 acetyl-coA synthetases in yeast,acetyl CoA syntheta\nse,Null mutant is viable and grows on ethanol or glucose (bu\nt not acetate) as sole carbon source (but with long lag-phas\ne); acs1 acs2 double null mutant is inviable\n mJEN1:Repressed by glucose, induced by lactic acid; in high copy, \nweakly suppresses cpr3 null mutan phenotype on lactate mediu\nm at 37 degrees,carboxylic acid transporter protein homolog,\ndeletion results in slow growth of yeast in synthetic medium\n supplemented with L-lactate and synergistic with cpr3 null \nmutation; essential for lactate uptake in yeast\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mGPG1:Unknown ,, Unknown\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSPS100:involved in spore development,sporulation-specific cell wall\n maturation protein,Null mutant is viable.\n mFBP1:fructose-1,6-bisphosphatase,fructose-1,6-bisphosphatase,unab\nle to grow with ethanol\n mECM13:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Cond687:gal1+gal\n Cond433:YPD_stationary_phase_28_d_ypd-1\n mATH1:Null mutant is viable; increased tolerance to dehydration, f\nreezing, and toxic levels of ethanol,acid trehalase,Null mut\nant is viable; shows lack of vacuolar acid trehalase activit\ny\n mYGR243W:Unknown ,, Unknown\n mIDP3:peroxisomal NADP-dependent isocitrate dehydrogenase,NADP-dep\nendent isocitrate dehydrogenase,Null mutant is viable but is\n unable to grow on polyunsaturated fatty acids as sole carbo\nn source\n Cond845:expt8\n mSPS19:late sporulation specific gene which may function during spo\nre wall formation,2,4-dienoyl-CoA reductase,Null mutant is v\niable. SPS19 is dispensable for growth and sporulation on so\nlid acetate and oleate media, but is essential for these pro\ncesses to occur on petroselineate.\n Cond690:gal4+gal\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mFOX2:peroxisomal multifunctional beta-oxidation protein,multifunc\ntional beta-oxidation protein,mutant lacks 2-enoyl-CoA hydra\ntase and D-3-hydroxyacyl-CoA dehydrogenase activities\n mYNL203C:Unknown ,, Unknown\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mADY2:Accumulation of DYads,,Null mutant is viable; forms predomin\nantly asci containing 2 spores (dyads) whensporulated; requi\nred for long-term growth on YPD at 37 degrees C.\n Cond320:heat_shock_17_to_37,_20_minutes\n mCRC1:carnitine carrier,carnitine transporter,Null mutant is viabl\ne\n mARO10:Hypothetical ORF,,\n mPIG2:Interacts with Gsy2p,30% identity to YER054C/GIP2,Null mutan\nt is viable and shows no detectable changes in glycogen meta\nbolism\n mPXA1:Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-b\ninding cassette transporter necessary for transport of long-\nchain fatty acids into peroxisomes,ABC transporter of long-c\nhain fatty acids,Null mutant is viable but cannot grow on me\ndia with oleic acid as sole carbon source\n mSPG1:Hypothetical ORF,,Null mutant is viable; SPG1 is required fo\nr long-term survival in YPD at 37 degrees C.\n Cond896:STAT\n mDIA3:involved in invasive and pseudohyphal growth,,Null mutant is\n viable and causes invasive growth in haploids and pseudohyp\nhal growth in diploids\n mUIP4:Unknown ,, Unknown\n mMSC1:Meiotic Sister-Chromatid recombination,,\n Cond941:SK1_YPD\n mPOT1:peroxisomal 3-oxoacyl CoA thiolase,3-oxoacyl CoA thiolase,Nu\nll mutant is viable, unable to use oleic acid as a carbon so\nurce\n mYBL049W:Unknown ,, Unknown\n mECM4:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond447:ethanol_vs._reference_pool_car-1\n Cond745: Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYKL187C:Unknown ,, Unknown\n Cond426:YPD_stationary_phase_1_d_ypd-1\n Cond457:YP_mannose_vs_reference_pool_car-2\n Cond705:gal1gal10+gal\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mYJR008W:Unknown ,, Unknown\n Cond420:YPD_3_d_ypd-2\n Cond857:pm38-gtoe\n mPDH1:Prpd homolog (ie the propionate operon of many prokary. spec\nifically prpD); close homologs (known to be essential for pr\nopionate utilization) in prokaryotes (several of these homol\nogs are called prpD), & it is transcribed in yeast.,,\n Cond449:glucose_vs._reference_pool_car-1\n mPCK1:phosphoenolpyruvate carboxylkinase,phosphoenolpyruvate carbo\nxylkinase,Null mutant is viable.\n Cond354:2.5mM_DTT_005_min_dtt-1\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond450:mannose_vs._reference_pool__car-1\n Cond871:yhe710-ss\n Cond419:YPD_2_d_ypd-2\n Cond451:raffinose_vs._reference_pool_car-1\n Cond844:expt7\n Cond431:YPD_stationary_phase_13_d_ypd-1\n mOM45:45-kDa mitochondrial outer membrane protein,45 kDa mitochond\nrial outer membrane protein,Null mutant is viable and shows \nnormal growth, viability, mitochondrial function and mitocho\nndrial protein import\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n Cond456:YP_glucose_vs_reference_pool_car-2\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n mALD6:Utilizes NADP+ as the preferred coenzyme. Activated by Mg2+.\n,aldehyde dehydrogenase,Null mutant is viable, grows at appr\noximately one-third the rate of wild-type, unable to grow on\n ethanol as a carbon source\n mSOL4:similar to SOL3,,\n Cond417:YPD_12_h_ypd-2\n Cond838:expt1\n mUGX2:Product of gene unknown,,\n Cond403:Nitrogen_Depletion_3_d\n Cond415:YPD_8_h_ypd-2\n Cond685:wt-gal\n Cond402:Nitrogen_Depletion_2_d\n mYLR149C:Unknown ,, Unknown\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond732:fkh1,2_alpha_factor_000_min_y12n57\n mNCA3:With NCA2, regulates proper expression of subunits 6 (Atp6p)\n and 8 (Atp8p ) of the Fo-F1 ATP synthase,,Null mutant is vi\nable\n Cond401:Nitrogen_Depletion_1_d\n mPUT1:proline oxidase,proline oxidase,inability to use proline as \na nitrogen source\n mPUT4:putative proline-specific permease,proline-specific permease\n (putative),inability to use proline as a nitrogen source\n mSIP18:Salt-Induced Protein,,Null mutant is viable.\n Cond411:diauxic_shift_timecourse_20.5_h\n mYIL057C:Unknown ,, Unknown\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mYMR114C:Unknown ,, Unknown\n Cond699:gal4-gal\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond421:YPD_5_d_ypd-2\n mMLS1:carbon-catabolite sensitive malate synthase,carbon-catabolit\ne sensitive malate synthase,Null mutant is viable\n Cond428:YPD_stationary_phase_3_d_ypd-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond958:t0.5_g/r_ratio\n Cond703:gal10-gal\n
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Computational Genomics Lab, Tel-Aviv uniresity