Module number 1040




Database revision : gnsdb28.10
Date : Tue Feb 25 17:34:54 2003
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mNEO1:ATPase that leads to neomycin-resistant protein when overexp\nressed,P-type ATPase,Null mutant is inviable. When overexpre\nssed, Neo1 confers neomycin resistance.\n mTIM17:Mitochondrial inner membrane protein involved in protein imp\nort,16.5 kDa inner membrane protein required for import of m\nitochondrial precursor proteins,Null mutant is inviable\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mVAC8:An armadillo repeat-containing protein localized on the vacu\nolar membrane,armadillo repeat-containing protein,Defective \nin vacuole inheritance and aminopeptidase I targeting to the\n vacuole\n mYGR026W:Unknown ,, Unknown\n mSKN1:Involved in (1->6)-beta-glucan biosynthesis,highly homologou\ns to Kre6p , type II membrane protein (putative),Null mutant\n is viable; exhibits no alterations in killer sensitivity, g\nrowth, or (1->6)-beta-glucan levels; skn1 kre6 double deleti\non mutants show a dramatic reduction in both (1-->6)-beta-gl\nucan levels and growth rate compared with either single disr\nuptant\n mSML1:Suppressor of mec lethality,,Null mutant is viable and suppr\nesses mec1 and rad53 lethality; suppresses mip1-1 at 37 C, s\nuppresses dun1 DNA damage sensitivity; increased resistance \nto DNA damage; increased dNTP pools\n mORM1:Product of gene unknown,,\n mYKL146W:Unknown ,, Unknown\n mDFG10:Protein required for filamentous growth, cell polarity, and \ncellular elongation,,Null mutant is viable and defective in \nfilamentous growth\n Cond711:t2+Vec\n mYKL084W:Unknown ,, Unknown\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n mPPQ1:May play role in regulation of translation,protein phosphata\nse Q,Null mutants are viable, show an altered morophology, h\nave a slight growth defect on several carbon sources, have l\nower cell density in stationary phase in the absence of an e\nssential amino acid, show a reduced rate of protein synthesi\ns in exponential phase, are hypersensitive to protein synthe\nsis inhibitors, and have an allosuppressor phenotype in supp\nressor strain backgrounds (i.e. enhanced efficiency of trans\nlational suppressors),\n mLAP3:aminopeptidase of cysteine protease family; bleomycin hydrol\nase,aminopeptidase of cysteine protease family,Null mutant i\ns viable with no obvious growth defects but is leucine amino\npeptidase deficient and hypersensitive to bleomycin; overexp\nression confers resistance to bleomycin\n mUTR4:Product of gene unknown,,\n mYPR196W:Unknown ,, Unknown\n mNPY1:hydrolyzes the pyrophosphate linkage in NADH and related nuc\nleotides,NADH pyrophosphatase 1,No readily detected phenotyp\ne\n mLAT1:Dihydrolipoamide acetyltransferase component (E2) of pyruvat\ne dehydrogenase complex,pyruvate dehydrogenase complex dihyd\nrolipoamide acetyltransferase component (E2),Null mutant is \nviable\n mYJR116W:Unknown ,, Unknown\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n mASP1:Asparaginase I, intracellular isozyme,asparaginase I , intra\ncellular isozyme,Aspartic acid requiring\n mPIS1:phosphatidylinositol synthase,phosphatidylinositol synthase,\nNull mutant is inviable\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mSHP1:isolated as a suppressor of the lethality caused by overexpr\nession of the phosphoprotein phosphatase 1 catalytic subuniu\nt encoded by GLC7,,Null mutant is viable; sporulation defect\nive, slow growth; is deficient in glycogen accumulation; low\n Glc7p specific activity\n mRPS13:Homology to rat S13,ribosomal protein S13 (S27a) (YS15),\n Cond724:t4+SSD1,H44\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n Cond889:4NQO_2\n mGAS5:Unknown ,, Unknown\n mSNU13:RNA binding protein (putative), similar to Nhp2p,U4/U6.U5 sn\nRNP component,the null mutant is inviable\n Cond713:t4+Vec\n mTHR1:homoserine kinase,homoserine kinase,Null mutant is viable, t\nhreonine auxotroph\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mRPA14:14 kDa subunit of RNA polymerase I,RNA polymerase I subunit,\nNull mutant is viable but is temperature sensitive\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n Cond718:t4+SSD1wt\n mSTE24:zinc metallo-protease that catalyzes the first step of N-ter\nminal processing of the yeast a-factor precursor,zinc metall\no-protease,Null mutant is viable, exhibits a mating efficien\ncy of ~5% that of a wild-type strain and an a-factor process\ning defect\n Cond888:MNNG_2\n mYJR015W:Unknown ,, Unknown\n mZEO1:Overexpression yields resistance to Zeocin,,Null mutant is v\niable and exhibits slow growth in galactose\n Cond722:t2+SSD1,H44\n mYMR148W:Unknown ,, Unknown\n Cond588:cdc15_230\n mGLN1:glutamine synthetase,glutamine synthetase,Glutamine syntheta\nse non-derepressible\n mYPR114W:Unknown ,, Unknown\n Cond709:t0+Vec\n mSNC1:Involved in mediating targeting and transport of secretory p\nroteins; forms a complex with Snc2p and Sec9p,Snc2p homolog \n, synaptobrevin homolog,Null mutant is viable; snc1 snc2 mut\nants are deficient in normal bulk secretion, accumulate larg\ne numbers of post-Golgi vesicles, and display a variety of c\nonditional lethal phenotypes; snc1 mutations suppress loss o\nf cap in strains possessing an activated ras2 allele\n mYMR010W:Unknown ,, Unknown\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n mYDL237W:Unknown ,, Unknown\n Cond717:t2-SSD1\n mYOL092W:Unknown ,, Unknown\n mCDC91:member of major facilitator superfamily,,\n mYAL053W:Unknown ,, Unknown\n mSTP3:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n Cond716:t2+SSD1wt\n mCTR2:Putative low-affinity copper transport protein,,ctr2 mutants\n display a high level of resistance to toxic copper concentr\nations. CTR2 overexpression provides increased resistance to\n copper starvation and is also associated with an increased \nsensitivity to copper toxicity.\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n Cond708:t0+SSD1\n Cond725:t4-SSD1,M31\n mYIL121W:Unknown ,, Unknown\n mSPT16:global regulator of transcription,,suppression of Ty inserti\non mutations\n mYIL041W:Unknown ,, Unknown\n mPAU6:member of the seripauperin protein/gene family,,\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mYHR181W:Unknown ,, Unknown\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n mOST4:May be subunit or accessory component of oligosaccharyltrans\nferase,3.6 kDa protein, probably membrane-located,Null mutan\nt is viable but is cold- and heat-sensitive; vanadate-resist\nant, hygromycin B-sensitive; defective in oligosaccharyltran\nsferase activity in vivo and in vitro\n mYNL190W:Unknown ,, Unknown\n Cond723:t2-SSD1,M31\n mGSF2:Glucose Signaling Factor,,A Tn3 insertion into this gene cau\nses hypersensitivity to the cell surface polymer perturbing \nagent calcofluor white; Defective in glucose repression; mut\nants decrease transcriptional repression by MIG1; alter gluc\nose-regulated subunit interactions within the Snf1 protein k\ninase complex; the effects of eff1 and eff2 on SUC2 repressi\non are strongly synergistic.\n mOST6:Putative new 37kDa subunit of N-oligosaccharyltransferase co\nmplex,N-oligosaccharyltransferase complex 37kDa subunit (put\native),\n mYJL217W:Unknown ,, Unknown\n mGAL80:inhibits transcription activation by Gal4p in hte absence of\n galactose,transcriptional regulator,Null mutant is viable a\nnd cannot utilize galactose.\n Cond715:t0-SSD1\n mDOT5:Derepression Of Telomeric silencing,,\n mZRT3:Hypothetical ORF,,\n mKTR1:mannosyltransferase involved in O- and N-linked glycosylatio\nn,type II transmembrane protein,Null mutant is viable\n mDAL4:allantoin transport,allantoin permease,Null mutant is viable\n, lacks allantoin transport capability\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mYMC1:putative mitochondrial carrier protein,carrier protein (puta\ntive),\n mFCY1:cytosine deaminase highly homologous to Candida albicans cyt\nosine deaminase,cytosine deaminase,Mutant is resistant to 5-\nfluorocytosine and shows total loss of cytosine deaminase ac\ntivity\n mYRF1-4:Y'-helicase protein 1,Y'-helicase protein 1,\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mATP15:nuclear gene for ATP synthase epsilon subunit,ATP synthase e\npsilon subunit , nuclear encoded,unable to grow on glycerol \nmedium; no detectable oligomycin-sensitive ATPase activity; \noligomycin-sensitive uncoupling of the mitochondrial respira\ntion rate\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n Cond710:t2+SSD1\n mTOM40:Translocase of Outer Mitochondrial membrane,forms the outer \nmembrane import channel , mitochondrial outer membrane prote\nin , forms the outer membrane import channel , mitochondrial\n outer membrane protein,Null mutant is inviable; cells accum\nulate uncleaved mitochondrial precursor proteins\n mYDL046W:Unknown ,, Unknown\n mYIL039W:Unknown ,, Unknown\n mYKL051W:Unknown ,, Unknown\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n mSML1 mADH3
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Computational Genomics Lab, Tel-Aviv uniresity