Module number 1028




Database revision : gnsdb28.10
Date : Tue Feb 25 17:32:25 2003
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mADY2:Accumulation of DYads,,Null mutant is viable; forms predomin\nantly asci containing 2 spores (dyads) whensporulated; requi\nred for long-term growth on YPD at 37 degrees C.\n mCIN1:Protein involved in chromosome segregation, required for mic\nrotubule stability,tubulin folding cofactor D,Null mutant is\n viable, exhibits cold sensitivity for viability; defect in \nnuclear migration and nuclear fusion, supersensitivity to be\nnomyl and nocodozole\n mGUT1:Glycerol utilization,converts glycerol to glycerol-3-phospha\nte , glyerol kinase,Null mutant is viable but is unable to g\nrow on glycerol\n mYPL201C:Unknown ,, Unknown\n mADY3:Protein involved in Accumulation of DYads,,forms largely asc\ni that contain 2 spores (dyads) when sporulated\n mRAD61:Unknown ,, Unknown\n mREG2:Possible regulatory subunit for the PP1 family protein phosp\nhatase Glc7p,,Null mutant is viable; reg1 reg2 double mutant\ns exhibit a severe growth defect (suppressed by loss-of-func\ntion mutation in snf1); overexpression of REG2 complements s\nlow-growth defect of a reg1 mutant but not the defects in gl\nycogen accumulation or glucose repression\n Cond698:gal3-gal\n mCRC1:carnitine carrier,carnitine transporter,Null mutant is viabl\ne\n mYBR051W:Unknown ,, Unknown\n mSRT1:cis-prenyltransferase homologue,cis-prenyltransferase,Null m\nutant is viable, grows at all temperatures tested and is not\n hygromycin B sensitive; srt1 rer2 double disruption mutants\n are inviable; overexpression of SRT1 suppresses the tempera\nture sensitive and slow growth phenotypes of rer2 mutants\n mMLH3:Mutl Homolog,,Null mutant is viable. Null mutant exhibits re\nduced (70%) rate of meiotic cross over.\n Cond697:gal2-gal\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n mDLD1:mitochondrial enzyme D-lactate ferricytochrome c oxidoreduct\nase,D-lactate ferricytochrome c oxidoreductase,Null mutant i\ns viable and cannot grow on media containing lactate as the \nsole carbon source\n mCYB2:Expression is repressed by glucose and anaerobic conditions,\n is induced by L-lactate and is regulated by GRR1, ROX3, HAP\n1, HXK2 and CYC8,L-lactate cytochrome c oxidoreductase , cyt\nochrome b2,Null mutant is viable but is deficient in cytochr\nome b2 and L-lactate dehydrogenase activity and is unable to\n use L-lactate as a sole carbon source\n mYGR110W:Unknown ,, Unknown\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYBR259W:Unknown ,, Unknown\n mYGR067C:Unknown ,, Unknown\n mSPS1:dispensable for mitosis, involved in middle/late stage of me\niosis, required for spore wall formation,,Null mutant is via\nble\n mSNF3:glucose sensor,glucose sensor,Null mutant is viable, defecti\nve in high affinity glucose transport, unable to grow on low\n glucose media, unable to grow on raffinose; snf3 delta hxt1\n delta hxt2 delta hxt3 delta hxt4 delta cells are unable to \ngrow on media containing high concentrations of glucose (5%)\n but can grow on low-glucose (0.5%) media; expression of SNF\n3 abolishes growth of hxt1 delta hxt2 delta hxt3 delta hxt4 \ndelta cells on low-glucose medium\n mYKL187C:Unknown ,, Unknown\n Cond702:gal7-gal\n Cond696:gal1-gal\n mYMR206W:Unknown ,, Unknown\n Cond705:gal1gal10+gal\n Cond701:gal6-gal\n mMEK1:Disp. for chr. pairing & chr. condensation seen by in situ h\nybrid. Required for full double strand breaks, normal length\n synaptonemal complexes, meiotic recomb. & spore viability. \nmek1 is rescued by spo13 & in early recomb. function,meiosis\n-specific serine/threonine protein kinase,Null mutant is via\nble, however diploids homozygous for a mek1 null mutation pr\noduce only low percentages of viable spores, reduced spore v\niability is rescued by spo13 mutations\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mYOR019W:Unknown ,, Unknown\n mMIG1:Transcription factor involved in glucose repression,C2H2 zin\nc finger protein that resembles the mammalian Egr and Wilms \ntumour proteins,Null mutant is viable, exhibits partial dere\npression of numerous glucose regulated transcripts; MIG1 ove\nrexpression and deletion studies suggest that other represso\nrs such as MIG2 may act in a redundant fashion with MIG1\n Cond689:gal3+gal\n mCAT8:Zinc-cluster protein involved in activating gluconeogenic ge\nnes; related to Gal4p,zinc-cluster protein involved in activ\nating gluconeogenic genes; related to Gal4p,Null mutant is v\niable but unable to grow on non-fermentable carbon sources d\nue to failure to derepress all major gluconeogenic enzymes; \noverexpression of Cat8p suppress inability of snf1 and snf4 \nmutants to grow on ethanol\n Cond449:glucose_vs._reference_pool_car-1\n mPCK1:phosphoenolpyruvate carboxylkinase,phosphoenolpyruvate carbo\nxylkinase,Null mutant is viable.\n Cond693:gal7+gal\n Cond694:gal10+gal\n Cond871:yhe710-ss\n Cond700:gal5-gal\n mSPT7:Transcription factor,histone acetyltransferase SAGA complex \nmember , transcription factor,Null mutant is viable, exhibit\ns growth defects on glucose and galactose, fails to grow on \nmedia lacking inositol\n Cond688:gal2+gal\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mJEN1:Repressed by glucose, induced by lactic acid; in high copy, \nweakly suppresses cpr3 null mutan phenotype on lactate mediu\nm at 37 degrees,carboxylic acid transporter protein homolog,\ndeletion results in slow growth of yeast in synthetic medium\n supplemented with L-lactate and synergistic with cpr3 null \nmutation; essential for lactate uptake in yeast\n mALD6:Utilizes NADP+ as the preferred coenzyme. Activated by Mg2+.\n,aldehyde dehydrogenase,Null mutant is viable, grows at appr\noximately one-third the rate of wild-type, unable to grow on\n ethanol as a carbon source\n mYNL194C:Unknown ,, Unknown\n mGIP1:Glc7-interacting protein.,,sporulation defective\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mVAM6:Required for the vacuolar morphogenesis in yeast,,Null mutan\nt is viable but exhibits defects in processing vacuolar prot\neases and in maturation of vacuolar alkaline phosphatase. Mu\ntants also exhibit a defective vacuolar morphology; they con\ntain several small vesicles that stain with vacuolar markers\n.\n mZDS2:multicopy suppressor of a sin4 defect,,Null mutant is viable\n; zds1 zds2 double deletion causes slow growth and defects i\nn bud morphology and cell cycle progression\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFBP1:fructose-1,6-bisphosphatase,fructose-1,6-bisphosphatase,unab\nle to grow with ethanol\n Cond685:wt-gal\n Cond686:wt+gal\n Cond687:gal1+gal\n mMMS4:Product of gene unknown,,null is synthetically lethal with s\ngs1 null\n Cond707:gal4gal80-gal\n mBOI1:Involved in bud growth,,Null mutant is viable.\n mYIL057C:Unknown ,, Unknown\n mHBT1:Unknown ,, Unknown\n mHXT1:High-affinity hexose (glucose) transporter,high affinity hex\nose (glucose) transporter,Null mutant is viable\n mHSL1:Negative regulator of swe1 kinase (which regulates cdc28),pr\notein kinase (putative) , similar to S. pombe cdr1/nim1,Nul\nl mutant is viable; synthetically lethal with histone H3 mut\nations; G2 delay\n mYFR054C:Unknown ,, Unknown\n mHXT3:Low-affinity glucose transporter,low affinity glucose transp\norter,Null mutant is viable but grows slowly on galactose; s\nome mutant alleles confer sodium hypersensitivity.\n mHXT4:hexose transporter,high affinity glucose transporter,Null mu\ntant is viable\n Cond690:gal4+gal\n mHXT10:high-affinity hexose transporter,high affinity hexose transp\norter,\n Cond699:gal4-gal\n mHXT6:Repression of HXT6 expression by glucose requires SNF3,hexos\ne transporter,Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt\n4 hxt6 hxt7 mutant cannot grow on media containing glucose a\ns sole carbon source\n mFOX2:peroxisomal multifunctional beta-oxidation protein,multifunc\ntional beta-oxidation protein,mutant lacks 2-enoyl-CoA hydra\ntase and D-3-hydroxyacyl-CoA dehydrogenase activities\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mHXT8:High-affinity hexose transporter,hexose permease,\n mPRR2:,protein kinase,\n Cond703:gal10-gal\n
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Computational Genomics Lab, Tel-Aviv uniresity