Module number 1026




Database revision : gnsdb28.10
Date : Tue Feb 25 17:32:22 2003
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Cond796:Ca5'\n Cond399:Nitrogen_Depletion_8_h\n Cond798:Ca30'\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond302:Heat_Shock_15_minutes_hs-1\n mBUD3:cell cycle regulated protein required for axial bud formatio\nn; co-assembles with Bud4p at bud sites,,Null mutant is viab\nle; bipolar budding pattern in all cell types\n Cond675:MHY1_(dun1)_+_heat_20_min\n Cond751: mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mUTR2:Product of gene unknown,,\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond315:37C_to_25C_shock_-_15_min\n mRPA135:135 kDa subunit of RNA polymerase I,RNA polymerase I subunit\n,suppression of rpb1, cold sensitive\n mSAP185:SIT4 associated protein, MW of 185 kDa,,Null mutant is viabl\ne; sap185 sap190 double mutants grow slowly; sap155 sap185 s\nap190 triple mutants are inviable in ssd1-d backgrounds\n Cond416:YPD_10_h__ypd-2\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond810:Na45'\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n mYGL239C:Unknown ,, Unknown\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond769:Acid_80'\n Cond393:aa_starv_4_h\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond395:Nitrogen_Depletion_30_min.\n Cond553:alpha14\n Cond752: TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond312:Heat_Shock_015_minutes_hs-2\n Cond404:Nitrogen_Depletion_5_d\n Cond749: mRET1:second-largest subunit of RNA polymerase III,,Null mutant is\n inviable\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond452:sucrose_vs._reference_pool_car-1\n mYJR041C:Unknown ,, Unknown\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n Cond797:Ca15'\n Cond367:dtt_240_min_dtt-2\n mSPT5:transcription factor,transcription factor,Null mutant is inv\niable\n mPMA1:major regulator of cytoplasmic pH,plasma membrane H+-ATPase,\ninviable; pma1 mutants are resistant to Dio-9, ethidium brom\nide and guanidine derivatives\n Cond313:Heat_Shock_030inutes__hs-2\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond385:Hypo-osmotic_shock_-_15_min\n Cond378:1M_sorbitol_-_15_min\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mYPR089W:Unknown ,, Unknown\n mRMT2:Protein Arginine Methyltransferase; R = arginine; MT = methy\nltransferase,arginine methyltransferase,Null mutant is viabl\ne\n Cond413:YPD_4_h_ypd-2\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond746: Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n Cond374:1.5_mM_diamide_(50_min)\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond370:1.5_mM_diamide_(10_min)\n Cond959:t2_g/r_ratio\n Cond809:Na30'\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n mDHR2:Unknown ,, Unknown\n mYPL044C:Unknown ,, Unknown\n Cond859:ms221-30\n Cond366:dtt_120_min_dtt-2\n mYLL034C:Unknown ,, Unknown\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond750: Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond801:CaFK15'\n mKRE25:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n Cond390:aa_starv_0.5_h\n Cond464:37_deg_growth_ct-1\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond448:galactose_vs._reference_pool_car-1\n Cond316:37C_to_25C_shock_-_30_min\n Cond396:Nitrogen_Depletion_1_h\n mPOL5:DNA polymerase V that has motifs typical of DNA polymerase f\namily,,\n Cond301:Heat_Shock_10_minutes_hs-1\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mBRX1:Essential nucleolar protein required for biogenesis of the 6\n0S ribosomal subunit,,inviable\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n Cond782:Peroxide_40'\n Cond800:CaFK5'\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond669:mec1_plus_gamma_120_min\n Cond386:Hypo-osmotic_shock_-_30_min\n mVAS1:mitochondrial and cytoplasmic valyl-tRNA synthetase,valine-t\nRNA ligase,Null mutant is inviable\n Cond375:1.5_mM_diamide_(60_min)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond371:1.5_mM_diamide_(20_min)\n mYHR020W:Unknown ,, Unknown\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mKRE33:Killer toxin REsistant ,,Heterozygous diploid mutant exhibit\n haploinsufficiency K1 killer toxin resistance\n Y-Stre.Acid:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNL087W:Unknown ,, Unknown\n Cond855:pm38-30\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mKAP95:protein involved in nuclear import; required for the docking\n of import substrate to the nuclear membrane/pore; identifie\nd as an rna1-1 synthetic lethal,karyopherin beta (importin 9\n0) homolog (95 kDa),essential, ts mutant shows nuclear impor\nt defect\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n Cond753: Cond635:DES460_+_0.02%_MMS_-_30_min\n mYBR074W:Unknown ,, Unknown\n Cond322:heat_shock_25_to_37,_20_minutes\n mYIL019W:Unknown ,, Unknown\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n Cond466:steady_state_17_dec_C_ct-2\n Cond449:glucose_vs._reference_pool_car-1\n Cond387:Hypo-osmotic_shock_-_45_min\n Cond758:Heat_0'_(A)\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mRPG1:Exhibits significant sequence similarity with a subunit of t\nhe mammalian translation initiation factor 3,translation ini\ntiation factor eIF3 subunit,Null mutant is inviable; tempera\nture sensitive mutant arrests in G1 phase\n Cond450:mannose_vs._reference_pool__car-1\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYKL014C:Unknown ,, Unknown\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond419:YPD_2_d_ypd-2\n Cond451:raffinose_vs._reference_pool_car-1\n Cond321:heat_shock_21_to_37,_20_minutes\n mPUS7:Unknown ,, Unknown\n mNOC3:NucleOlar Complex 2; involved in the nuclear export of pre-r\nibosomes,,\n Cond329:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_5_minutes\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mTRM82:Unknown ,, Unknown\n mKEL3:Kelch-repeat protein, similar to Kel1 and Kel2,kelch-repeat \nprotein , similar to Kel1 and Kel2,\n mNAN1:Net1-Associated Nucleolar protein 1,,Null mutant is inviable\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n Cond799:Ca60'\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond403:Nitrogen_Depletion_3_d\n mRPO31:RNA polymerase III large subunit,RNA polymerase III subunit,\nNull mutant is inviable\n Cond415:YPD_8_h_ypd-2\n mUTP14:Unknown ,, Unknown\n Cond319:37C_to_25C_shock_-_90_min\n Cond402:Nitrogen_Depletion_2_d\n Cond811:Na60'\n Cond372:1.5_mM_diamide_(30_min)\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTIF4631:also called eIF4 (eIF-4) gamma,150 kDa subunit , Tif4632p an\nd mammalian p220 homolog , mRNA cap binding protein eIF-4F,N\null mutant is viable, grows slowly and is cold-sensitive. ti\nf4631 tif4632 double deletion mutants are inviable\n Cond682:MHY1_(crt1)_vs_CRY1_(wild_type)\n Cond401:Nitrogen_Depletion_1_d\n Cond324:heat_shock_33_to_37,_20_minutes\n mPFK1:phosphofructokinase alpha subunit,phosphofructokinase alpha \nsubunit,Null mutant is viable, accumulates fructose-6-phosph\nate, glucose-6-phosphate, and sedoheptulose-7-phosphate, exh\nibits decreased levels of fructose-1,6-bisphosphate; pfk1 pf\nk2 double deletion mutants fail to grow on 2% glucose\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mDIS3:Possible component of RCC1-Ran pathway,3'-5' exoribonuclease\n complex subunit,Null mutant is inviable\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mPPT1:serine/threonine phosphatase,,\n mEMP70:identified as a 24 kDa cleavage product in endosome-enriched\n membrane fractions,,\n mFYV15:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is viable but a hHeterozygous diploid mutant exhibi\nt haploinsufficiency K1 killer toxin hypersensitivity.\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond980:F82G_10_mM_1NaPP1\n mPHO90:Low-affinity phosphate transporter,,\n Cond858:pm71-30\n mUTP21:Unknown ,, Unknown\n Cond671:DES459_(mec1)_-_mock_irradiation_-_30_min\n Cond979:WT_10_mM_1NaPP1\n mUTP22:Unknown ,, Unknown\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond660:DES460_(wt)_-_mock_irradiation_-_60_min\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond958:t0.5_g/r_ratio\n
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Computational Genomics Lab, Tel-Aviv uniresity