Module number 1023




Database revision : gnsdb28.10
Date : Tue Feb 25 17:32:14 2003
How to read this figure?


mCDC37:cell cycle protein necessary for passage through START,,Null\n mutant is inviable; temperature-sensitive mutants arrest in\n G1 and form shmoo morphology at the restrictive temperature\n mYDR071C:Unknown ,, Unknown\n Cond798:Ca30'\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mUBC13:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n mGGA1:Golgi-localized, gamma-adaptin homology, Arf-binding,ARF-bin\nding protein,\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYDR391C:Unknown ,, Unknown\n mUMP1:Involved in ubiquitin-mediated proteolysis,20S proteasome ma\nturation factor,Null mutant is viable, grows slower than wil\nd-type, is hypersensitive to cadmium ions and canavanine, ac\ncumulates Ub-protein conjugates; ump1 null homozygous diploi\nds fail to sporulate\n mUBC1:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable but exhibit moderately slow growth.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mPST2:Protoplasts-SecreTed protein; the gene product was detected \namong the proteins secreted by regenerating protoplasts,,\n Cond373:1.5_mM_diamide_(40_min)\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mMAG1:3-methyladenine DNA glycosylase,3-methyladenine DNA glycosyl\nase,Null mutant is viable, deficient in 3-methyladenine DNA \nglycosylase activity and shows enhanced sensitivity to sever\nal monofunctional alkylating agents\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n Cond802:CaFK30'\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond376:1.5_mM_diamide_(90_min)\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mCDC53:acts together with Cdc4p and Cdc34p to control the G1-S phas\ne transition, assists in mediating the proteolysis of the Cd\nk inhibitor Sic1p in late G1,,Cells arrest in G1 with active\n Cln kinases but no Clb-associated Cdc28p kinase activity\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n mDOS2:Product of gene unknown,,\n mYDL027C:Unknown ,, Unknown\n Cond797:Ca15'\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mSDS22:Interacts with and may be a positive regulator of GLC7 which\n encodes type1 protein phosphatase,Glc7p regulatory subunit,\nNull mutant is inviable, lethality can be resuced by overexp\nression of GLC7\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYFR003C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mRIB5:Riboflavin biosynthesis,,Null mutant is viable, exhibits rib\noflavin auxotrophy\n Cond366:dtt_120_min_dtt-2\n mYBR204C:Unknown ,, Unknown\n mARN1:Product of gene unknown,,\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mYJL032W:Unknown ,, Unknown\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n mBMH2:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mFLR1:Fluconazole Resistance 1,major facilitator transporter,Null \nmutant is viable; overexpression confers resistance to fluco\nnazole, cycloheximide, 4-nitroquinoline N-oxide\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond801:CaFK15'\n mYDL180W:Unknown ,, Unknown\n mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n mYMR067C:Unknown ,, Unknown\n mTRR1:Thioredoxin reductase,thioredoxin reductase,Null mutant is v\niable but grow slowly; trr1 mutations are sensitive to hydro\ngen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi\n4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6\n null mutants.\n mYDL072C:Unknown ,, Unknown\n Cond982:pho85D_10_mM_1NaPP1_\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYDR031W:Unknown ,, Unknown\n mAAD3:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n mYDR533C:Unknown ,, Unknown\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mYPR1:homologous to the aldo-keto reductase protein family,,\n Cond800:CaFK5'\n Cond680:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison_,\n2\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mGTT2:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive in stationary phase\n Cond371:1.5_mM_diamide_(20_min)\n Cond375:1.5_mM_diamide_(60_min)\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mVTI1:Involved in cis-Golgi membrane traffic,interacts with two t-\nSNARES, Sed5p and Pep12p , v-SNARE,Null mutant is inviable\n mYDR003W:Unknown ,, Unknown\n mTSA2:Unknown ,, Unknown\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond346:1_mM_Menadione_(20_min)_redo\n mYMR315W:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mGSP2:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein , Gsp1p homolog,Null mutant is viable\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mRPN4:involved in ubiquitin degradation pathway,,Null mutant is vi\nable, exhibits synthetic interactions with sen3, sun1, and c\ndc28-1N\n mYDL124W:Unknown ,, Unknown\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mYDR330W:Unknown ,, Unknown\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n mARP2:Involved in endocytosis and membrane growth and polarity,act\nin related protein,Null mutant is inviable\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n mRPN9:Regulatory Particle Non-ATPase,proteasome regulatory particl\ne subunit,Null mutant is viable, temperature sensitive; rpn9\n rpn10 double deletion mutants are viable\n Cond379:1M_sorbitol_-_30_min\n mYDL023C:Unknown ,, Unknown\n mHXK1:Glucose phosphorylation,hexokinase I (PI) (also called hexok\ninase A),Null mutant is viable, is able to ferment fructose,\n and has little or no effect on glucose repression; hxk1, hx\nk2 double null mutant cannot ferment fructose and fails to s\nhow glucose repression at SUC2, CYC1, GAL10\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mCPR1:cyclophilin peptidyl-prolyl cis-trans isomerase,cyclophilin \n, peptidyl-prolyl cis-trans isomerase (PPIase) , cyclophilin\n , peptidyl-prolyl cis-trans isomerase (PPIase),Null mutant \nis viable\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRE9:proteasome component Y13,proteasome component Y13,\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mSGT2:small glutamine-rich tetratricopeptide repeat containing pro\ntein,,\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n mTPK2:Involved in nutrient control of cell growth and division,cAM\nP-dependent protein kinase catalytic subunit,Null mutant hap\nloids are defective for invasive growth; diploid homozygous \nnull mutants are defective for pseudohyphal growth.\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mSLF1:Associates with translating ribosomes; may function in cytop\nlasm to modulate mRNA translation; regulates the copper-depe\nndent mineralization of copper sulfide complexes on cell sur\nface in cells cultured in medium containing copper salts,,Nu\nll mutant is viable, copper sensitive, has lost ability to d\neplete Cu, but not Cd ions from surrounding medium; SLF1 ove\nrexpression confers copper superresistance and enhances Ca d\nepletion ability\n mCOX5B:Cytochrome-c oxidase chain Vb,cytochrome c oxidase chain Vb,\nNull mutant is viable\n mAHA1:Unknown ,, Unknown\n mGLO1:Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-act\nivated protein) kinase pathway in osmotic stress response,la\nctoylglutathione lyase (glyoxalase I),Null mutant is viable;\n sensitive to methylglyoxal\n mSFA1:Long-chain alcohol dehydrogenase (glutathione-dependent form\naldehyde dehydrogenase),glutathione-dependent formaldehyde d\nehydrogenase , long-chain alcohol dehydrogenase,Null mutant \nis viable; sensitive to formaldehyde\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mSLU7:involved in 3' splice site choices and 2nd step of splicing,\n,Null mutant is inviable; synthetically lethal with prp16, p\nrp18 and U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo a\nnd in vitro\n Cond372:1.5_mM_diamide_(30_min)\n mYNK1:Nucleoside diphosphate kinase,nucleoside diphosphate kinase,\nNull mutant is viable, exhibits no defects in growth rate, s\npore formation, mating ability, or morphology\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n mVPS68:Unknown ,, Unknown\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n mGPD1:glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehy\ndrogenase,lethal under conditions of osmotic stress, unable \nto grow on glycerol\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mYLR345W:Unknown ,, Unknown\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mHSP42:Similar to HSP26; expression is regulated by stress conditio\nns,,Null mutant is viable; hsp42 hsp26 double deletion mutan\nts are viable; hsp42 null mutants subjected to moderate ther\nmal stress reorganize the actin cytoskeleton more slowly tha\nn wild-type\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mYDL025C:Unknown ,, Unknown\n mBTN2:Gene/protein whose expression is elevated in a btn1 minus/Bt\nn1p lacking yeast strain.,,Null mutant is viable; expression\n of BTN2 is elevated in yeast lacking BTN1\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mARR4:Unknown ,, Unknown\n
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity