Yeast functional modules and their transcriptional regulation


Database revision : gnsdb28.10
Date : Thu Feb 27 23:51:08 2003
Functional modules and their transcription factors in the yeast system. Modules with significant functional enrichment for a particular process (p<0.01) are grouped and plotted as ovals with the process name. TFs with binding profiles associated with any of these modules are marked as green circles and connected to the associated process. Modules enriched in more than one process may appear in several places in the figure. The thickness of the connecting lines is inversely proportional to the p-value of the functional enrichment in the associated module. The map was automatically generated by SAMBA using no prior biological knowledge. Key abbreviations: Met:  Metabolism, AA: Amino Acid, Tran: Transport. Click a node for additional information on the associated TF or process.

Derepression Of Telomeric silencing,, binds Sin3p in two-hybrid assay and is present in a large protein complex with Sin3p and Stb2p,,Null mutant is viable member of the leucine zipper family of transcriptional activators,leucine zipper family , transcriptional activator,Null mutant is viable, and is a methionine auxotroph homeobox domain similar human proto-oncogene PBX1,DNA binding protein (putative),Null mutant is viable, associated with loss of copper resistance involved in transcriptional regulation of CUP1,zinc finger transcription factor,Null mutant is viable, exhibits decreased CUP1 mRNA expression Involved in methionine metabolism,highly homologous to Met32p , transcriptional regulator of sulfur amino acid metabolism , zinc finger protein,the met31 met32 double mutant is a methionine auxotroph involved in regulation of glucose repression,binds to UAS-1 in the STA1 promoter and can interact with Ssn6p , transcriptional repressor,Null mutant is viable, relieves glucose repression of SUC2 and STA1; suppresses snf mutations Involved in pheromone and pseudohyphal growth signal transduction pathways,transcription factor,Null mutant is viable but sterile; homozygous mutant diploids exhibit defects in pseudohyphal growth Global regulator of respiratory genes,transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer), Regulates respiratory functions; encodes divergent overlapping transcripts,transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer), serum response factor-like protein that may function downstream of MPK1 (SLT2) MAP-kinase pathway,,Null mutant is viable but shows caffeine sensitivity Regulates respiratory functions; encodes divergent overlapping transcripts,transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer), Involved in cell cycle dependent gene expression,transcription factor,Null mutant is viable, deficient in homothallic switching, and temperature sensitive Protein involved in silencing,bZIP (basic-leucine zipper) protein , can activate transcription from a promoter containing a Yap recognition site , bZIP (basic-leucine zipper) protein , can activate transcription from a promoter containing a Yap recognition site,Null mutant is viable and suppresses the cold sensitivity of yap1 mutants Regulates respiratory functions; subunit of a heterotrimeric complex required for CCAAT binding,CCAAT-binding transcription factor component (along with Hap2p and Hap3p),Null mutant is viable jun-like transcription factor,jun-like transcription factor,pleiotropic drug resistance transcriptional activator,transcriptional activator,homothallic switching deficient Involved in cell cycle dependent gene expression,transcription factor,Null mutant is viable and deficient in homothallic switching Multicopy Suppressor of STA10 - 11,758 amino acid polypeptide with poly-glutamine and poly-asparagine domains,Null mutant is viable, exhibits diminished transcription of STA2; multiple copies suppress repressive effect of STA10, enhance expression of STA2 in non-STA10 strains bZIP protein; transcription factor,bZIP (basic-leucine zipper) protein , transcription factor, Positive regulator of multiple nitrogen catabolic genes,transcriptional activator for allantoin and GABA catabolic genes, contains a Zn[2]-Cys[6] fungal-type binuclear cluster domain in the N-terminal region,Null mutant is viable, unable to degrade allantoin Zinc-finger inhibitor of HO transcription which is asymmetrically localized to the daughter cell nucleus,,Mutant ash1 daughters can transcribe HO and switch mating type bZIP protein,, general positive regulator of permeability genes,zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type,pleiotropic drug resistance, resistant to borrelidin, oligomycin, antimycin, cycloheximide, antibiotic, thioisoleucine, sulfometuron methyl; accumulation of neutral red Protein with similarity to DNA-binding region of heat shock transcription factors,,Null mutant is viable Transcription factor of the MADS (Mcm1p, Agamous, Deficiens, SRF) box family; closely related to RLM1,,Null mutant is viable; overexpression of DNA-binding domain of SMP1 causes an 'osmoremedial' phenotype calcineurin responsive zinc-finger,transcription factor (putative),Null mutant is viable Putative transcriptional repressor with proline-rich zinc fingers,transcriptional repressor with proline-rich zinc fingers (putative),Null mutant is viable; overexpression of RGM1 greatly impairs cell growth. heat shock transcription factor,heat shock transcription factor,Null mutant is inviable The ROX1 gene encodes a heme-induced repressor of hypoxic genes in yeast.,HMG-domain site-specific DNA binding protein.,The null mutant is viable but misexpresses several heme-regulated genes. Putative transcriptional regulator of rRNA-processing genes,domain similar to the fork head DNA-binding domain found in the developmental fork head protein of Drosophila melanogaster and in the HNF-3 family of hepatocyte mammalian transcription factors.,Null mutant shows reduced growth rate and lower rRNA content DNA-binding protein involved in either activation or repression of transcription, depending on binding site context. Also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure.,repressor activator protein,null is inviable; some mutations abolish silencing (at telomeres and at the silent mating-type loci), other mutations or overproduction alter telomere length Nuclear Division Defective 1,,Null mutant is inviable and arrests prior to nuclear division but after DNA replication; cells are large budded with short mitotic spindles. Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis,helix-loop-helix protein,The null mutant is viable but auxotrophic for inositol and choline. The null mutant can also display aberant cell shape and defects in nuclear segregation. Homozygous mutant ino2 delta-1 diploids fail to sporulate. Other mutant alleles show pleiotropic defects in phospholipid metabolism. Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis,basic helix-loop-helix (bHLH) protein,The null mutant is viable but auxotrophic for inositol and choline. The null mutant expresses repressed levels of inositol-1-phosphate synthase (INO1) mRNA and exhibits reduced phosphatidylcholine biosynthesis. Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase,transcription factor (putative),Null mutant is viable transcriptional activator and ARS1 binding protein,ARS1 binding protein , transcriptional activator , ARS1 binding protein , transcriptional activator , ARS1 binding protein , transcriptional activator,Null mutant is inviable Involved in cell-type-specific transcription and pheromone response,contains the 56 amino-acid MADS (MCM1, AG, DEFAm SRF)-box motif within its DNA binding domain, plays a central role in the formation of both repressor and activator complexes , transcription factor,Null mutant is inviable, Pro97Leu mutant is sterile, exhibits defects in minichromosome maintenance Transcription factor that activates expression of phosphate pathway,myc-family transcription factor, transcription factor,transcription factor, Positive regulator of GAL genes,zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant is viable, cannot utilize galactose as sole carbon source centromere binding factor; binds in vivo to CDE I sites in centromeres (and some promoters), and induces DNA bending, required for mitotic segregation and normal growth rate,basic helix-loop-helix protein,Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased chromosome loss), benomyl and thiabendazole sensitivity, methionine auxotrophy, and changes in chromatin structure at CENs and some promoters. Null mutation causes precocious sister segregation at MI, and reduced spore viability. Regulates glutamine-repressible gene products,transcriptional activator of nitrogen-regulated genes,Glutamine synthetase non-derepressible protein similar to StuA of Aspergillus nidulans,transcription factor (putative),Null mutant is viable, diploid homozygous null mutants undergo pseudohyphal growth when starved for nitrogen. Overexpression of PHD1 in diploids and in bud4 haploids causes precocious and unusually vigorous pseudohyphal growth transcriptional activator of amino acid biosynthetic genes,transcriptional activator of amino acid biosynthetic genes,The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-triazole. General control of amino acid synthesis non-derepressible in the null mutant. Suppresor of mar1-1 (sir2) mutation,,Restores silencing at HML and HMR in presence of sir2, sir3 and sir4 mutants trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families,trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families,Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well on medium with non-fermentable carbon sources; on permissive medium, the null mutant principally affects the expression of glycolytic enzyme genes and transcripts encoded by Ty elements. Mutant exhibits reduction in the intracellular concentration of enolase and glyceraldehyde-3-phosphate dehydrogenase polypeptides Involved in pre-tRNA splicing and in uptake of branched-chain amino acids,zinc finger motif protein,null is viable, but causes reduced efficiency of SUP4-mediated suppression, and is also sensitive to sulfonylurea herbicides on complex media (YPD); multiple copies enhance the suppression of SUP4(G37) The amino acid sequence of this ORF is very homologous to that of GAT4/YIR013C.,, activates transcription of glycolytic genes; homologous to GCR1; may function in complex with Gcr1p,transcription factor,Null mutant is viable and has partial growth defect on glucose-containing media Fork Head homolog two,, Zinc-regulated DNA binding protein involved in zinc ion homeostasis,metalloregulatory protein involved in zinc-responsive transcriptional regulation,High level expression of ZRT1 and ZRT2 in both zinc-limited and zinc-replete cells Reg. express. of genes involved in branched chain aa biosynth. & in ammonia assimilation. Mod. by alpha-isopropylmalate, intermediate in leu biosynth. With alpha-isopropylmalate becomes transcript. act.,zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant is viable, leaky leucine auxotroph High Copy Suppressor of MOT1-SPT3 synthetic lethality,2 Cys2-His2 zinc fingers at c-terminus, glutamine and asparagine rich,Null mutant is viable, displays modest increase in Ty mRNA levels; mot3 deletion can partially suppress mutations in mot1 and spt3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4),zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant is viable but exhibits defects in activation of UGA1 and UGA4. Transcription factor regulating basal and induced activity of histidine and adenine biosynthesis genes,transcription factor, Regulator of arginine-responsive genes with ARG81 and ARG82,transcription factor,Arginine requiring Regulator of arginine-responsive genes with ARG80 and ARG82 ,zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant is viable Transcription factor with domains homologous to myc oncoprotein and yeast Hsf1p required for normal cell surface assembly and flocculence,transcription factor,Mutational analysis of SFL1 demonstrates that it is required for normal cell-surface assembly in vegetative growth. Involved in iron homeostasis and affects cell size regulation,binds the consensus site PyPuCACCCPu , transcription factor (putative),Null mutant is viable; mutant cells are larger than normal, since critical size for budding is increased; mutant shows incorrect regulation of expression of genes involved in iron uptake; spores from heterozygous diploid have reduced ability to germinate; Down-regulator of Invasive Growth, Regulator of Sterile Twelve, binds Fus3 and Ste12,MAP kinase-associated protein,Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mating defect and invasive growth; overexpression causes pheromone resistance Inhibits nuclear protein localization when present in multiple copies,split zinc finger protein,Null mutant is viable, grows slowly, cells have multiple nucleated buds Involved in cell-cycle regulation of histone transcription,contains nuclear targeting signal , repressor protein (putative) , similar to Tup1p and mammalian retinal transducin,Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype Involved in cell-cycle regulation of histone transcription,contains nuclear targeting signal , repressor protein (putative),Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype transcription_initiation,,_from_Pol_II_promoter pheromone_response_(sensu_Fungi) mating_(sensu_Fungi) phosphorylation translational_fidelity ergosterol_metabolism histidine_biosynthesis autophagy aerobic_respiration 35S_primary_transcript_processing fatty_acid_biosynthesis chromatin_assembly/disassembly sporulation_(sensu_Saccharomyces) mitochondrial_translocation ubiquitin-dependent_protein_degradation DNA_metabolism hexose_transport protein_synthesis_elongation mRNA_metabolism DNA_replication_and_chromosome_cycle asparagine_metabolism RNA_processing ribosome_biogenesis branched_chain_family_amino_acid_biosynthesis protein_modification heavy_metal_ion_transport spore_wall_assembly_(sensu_Saccharomyces) vesicle_transport protein_biosynthesis cytoskeleton_organization_and_biogenesis amino_acid_transport serine_family_amino_acid_biosynthesis G2/M_transition_of_mitotic_cell_cycle cell_wall_organization_and_biogenesis glucose_metabolism tryptophan_biosynthesis exocytosis glycerophospholipid_metabolism methionine_metabolism amino_acid_metabolism mismatch_repair sulfate_assimilation oxidative_stress_response stress_response protein_folding tricarboxylic_acid_cycle cytokinesis transcription,,_DNA-dependent galactose_metabolism nuclear_division arginine_biosynthesis response_to_external_stimulus amino_acid_biosynthesis G1/S_transition_of_mitotic_cell_cycle mitotic_cell_cycle
this is an automaticly generated GENESYS report
Computational Genomics Lab, Tel-Aviv uniresity