Module ubiquitin-dependent_protein_degradation




Database revision : gnsdb28.10
Date : Fri Feb 28 01:36:32 2003
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mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n Cond368:dtt_480_min_dtt-2\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYMR067C:Unknown ,, Unknown\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n Cond896:STAT\n Cond982:pho85D_10_mM_1NaPP1_\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mUBC13:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n mMCH4:Unknown ,, Unknown\n Cond654:wt_plus_gamma_45_min\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n Cond883:5\n Cond898:RPN4\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond375:1.5_mM_diamide_(60_min)\n Cond373:1.5_mM_diamide_(40_min)\n Cond371:1.5_mM_diamide_(20_min)\n Cond880:BCNU\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n Cond940:6h\n Cond802:CaFK30'\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond:\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mERO1:involved in protein disulfide bond formation in the ER,,Null\n mutant is inviable; in ero1-1(ts) mutants newly synthesized\n carboxypeptidase Y is retained in the ER and lacks disulfid\ne bonds; ero1 mutants are hypersensitive to to the reductant\n DTT, whereas overexpression of ERO1 confers resistance to D\nTT, the oxidant diamide can restore growth and secretion in \nero1 mutants\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n Cond346:1_mM_Menadione_(20_min)_redo\n Cond376:1.5_mM_diamide_(90_min)\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR387C:Unknown ,, Unknown\n mPOB3:binds to catalytic subunit of DNA polymerase alpha (Pol1p),D\nNA polymerase delta binding protein,Null mutant is inviable\n Cond894:G2\n mRPN1:Subunit of 26S Proteasome (PA700 subunit),26S proteasome PA7\n00 subunit,Null mutant is inviable; hrd2-1 mutation slows de\ngradation of Hmg2p. hrd2-1 strains are sensitive to canavani\nne and show a global accumulation of ubiquitin-conjugated pr\noteins, but are not temperature-sensitive\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mYFL057C:Unknown ,, Unknown\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n Cond893:SMMS\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond379:1M_sorbitol_-_30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYOR052C:Unknown ,, Unknown\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRE8:proteasome component Y7,proteasome component Y7,\n mPRE9:proteasome component Y13,proteasome component Y13,\n Cond783:Peroxide_60'\n mSGT2:small glutamine-rich tetratricopeptide repeat containing pro\ntein,,\n Cond879:MMC\n mUFD1:Ubiquitin fusion degradation protein,,Homozygous ufd1-1 muta\nnt diploids exhibit sporulation defects.\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n Cond875:60min\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mYMR090W:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n Cond236:yjl107c(haploid)\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n Cond653:wt_plus_gamma_30_min\n mPUP2:Proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mPUP3:20S proteasome subunit beta3_sc,20S proteasome subunit beta3\n_sc,\n Cond349:1_mM_Menadione_(50_min)redo\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n Cond885:20\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n Cond881:4NQO\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mYKL091C:Unknown ,, Unknown\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond939:4h\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mNPL4 mUFD1 mRPT2 mRPN5 mRPT3 mRPN6 mRPN12 mRPN1 mRPT1 mRPN8 mRPN3 mRPT4 mRPN7 mRPT6
mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n mYNL134C:Unknown ,, Unknown\n mSET6:Hypothetical ORF,,\n Cond798:Ca30'\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond675:MHY1_(dun1)_+_heat_20_min\n mYOL048C:Unknown ,, Unknown\n Cond981:F82G_pho4D_10_mM_1NaPP1\n mYDR391C:Unknown ,, Unknown\n mYOR225W:Unknown ,, Unknown\n mUBC1:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable but exhibit moderately slow growth.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mMAG1:3-methyladenine DNA glycosylase,3-methyladenine DNA glycosyl\nase,Null mutant is viable, deficient in 3-methyladenine DNA \nglycosylase activity and shows enhanced sensitivity to sever\nal monofunctional alkylating agents\n mYOL150C:Unknown ,, Unknown\n mUBC8:Ubiquitin-conjugating enzyme that is able to ubiquitinate hi\nstones in vitro,ubiquitin-conjugating enzyme , ubiquitin-pro\ntein ligase,Null mutant is viable\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFBP26:Fructose-2,6-biphosphatase,Fructose-2,6-biphosphatase,Null m\nutant lacks fructose-2,6-biphosphatase activity but can grow\n on glucose, fructose, galactose, pyruvate, glycerol and lac\ntate\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n mYOR059C:Unknown ,, Unknown\n Cond673:DES460_(wild_type)_+_heat_20_min\n mDDR48:DNA damage inducible; implicated in the production or recove\nry of mutations,contains >35 repeats of the amino acid seque\nnce NNNDSYGS , flocculent specific protein,Null mutant is vi\nable, displays reduced spontaneous mutation rate\n mRTN2:Unknown ,, Unknown\n mYMR173W-A:Unknown ,, Unknown\n mAAD14:aryl-alcohol dehydrogenase located on chromosome 14,aryl-alc\nohol dehydrogenase (putative),\n mAAD15:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n mYNL274C:Unknown ,, Unknown\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n mYGR207C:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mSTI1:Heat shock protein also induced by canavanine and entry into\n stationary phase,heat shock protein also induced by canavan\nine and entry into stationary phase,Null mutant is viable bu\nt shows slow growth at high or low temperatures; shows synth\netic interactions with hsp82, cpr7, kin28 and sba1\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n Cond653:wt_plus_gamma_30_min\n mENB1:Siderophore transporter for enterobactin; AFT1 regulon,enter\nobactin transporter,Null mutants are viable but are unable t\no take up and utilize iron from enterobactin\n mYFR003C:Unknown ,, Unknown\n Cond370:1.5_mM_diamide_(10_min)\n Cond634:DES460_+_0.02%_MMS_-_15_min\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mHSP78:Similar to E. coli ClpB protein; involved in folding of some\n mitochondrial proteins,heat shock protein 78,Null mutant is\n viable but in ssc1 mutant background gives rho- phenotype\n mRIB5:Riboflavin biosynthesis,,Null mutant is viable, exhibits rib\noflavin auxotrophy\n mYMR110C:Unknown ,, Unknown\n mYOR285W:Unknown ,, Unknown\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mARN1:Product of gene unknown,,\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n mYLR356W:Unknown ,, Unknown\n mPHB1:antiproliferative protein involved in determination of repli\ncative life span,Phb2p homolog , mitochondrial protein,Null \nmutant is viable, exhibits a slightly decreased lifes span; \nphb1 phb2 double deletion mutants exhibit a more decreased r\neplicative lifespan and a defect in mitochondrial membrane p\notential\n mPRC1:dispensable for haploidization and sporulation, but required\n for full protein degradation during sporulation,carboxypept\nidase Y (proteinase C),Null mutant is viable,proteinase C de\nficient\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mTGL2:Triglyceride Lipase,triglyceride lipase,Null mutant is viabl\ne, exhibits no apparent phenotype\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond801:CaFK15'\n mYDL180W:Unknown ,, Unknown\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n mTOS5:Hypothetical ORF,,\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n mIKS1:ira1* kinase suppressor,serine/threonine kinase (putative),N\null mutant is heat shock sensitive\n Cond982:pho85D_10_mM_1NaPP1_\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n mAAD3:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n mYCL042W:Unknown ,, Unknown\n mMSC1:Meiotic Sister-Chromatid recombination,,\n mAAD6:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),Responds to oxidative s\ntress induced by diamide and di-ethyl maleic acid ester in Y\nAP1 dependant manner\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n mLAP3:aminopeptidase of cysteine protease family; bleomycin hydrol\nase,aminopeptidase of cysteine protease family,Null mutant i\ns viable with no obvious growth defects but is leucine amino\npeptidase deficient and hypersensitive to bleomycin; overexp\nression confers resistance to bleomycin\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n mYBR052C:Unknown ,, Unknown\n mYPR1:homologous to the aldo-keto reductase protein family,,\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n mPRD1:Saccharolysin (oligopeptidase yscD),,Null mutant is viable b\nut exhibits a decrease in the intracellular degradation of p\neptides\n mYKL100C:Unknown ,, Unknown\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mGTT2:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive in stationary phase\n Cond371:1.5_mM_diamide_(20_min)\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mVTI1:Involved in cis-Golgi membrane traffic,interacts with two t-\nSNARES, Sed5p and Pep12p , v-SNARE,Null mutant is inviable\n mZTA1:Zeta-crystallin homolog, has similarity to E. coli quinone o\nxidoreductase and human zeta-crystallin which has quinone ox\nidoreductase activity,,\n mNCE103:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mDDI1:DNA Damage Inducible; binds to T- and V- snare complexes,,Nu\nll mutant is viable\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYMR315W:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mYDL124W:Unknown ,, Unknown\n mYBR053C:Unknown ,, Unknown\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n mARA1:D-arabinose dehydrogenase,D-arabinose dehydrogenase,Null mut\nant is viable but cannot produce D-arabinono-1,4-lactone, a \nprecursor of D-erythroascorbic acid\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mYPS6:Gpi-anchored aspartic protease (Yapsin 6),GPI-anchored aspar\ntic protease,\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mPRE2:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne, pre2 mutants exhibit defects in chymotrypsin-like proteol\nysis, stress response and ubiquitin signaled protein degrada\ntion\n mYLR460C:Unknown ,, Unknown\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n mPRE4:B-type subunit of proteasome, euk. & archae. multicatalytic \nproteinase complex likelyinvolved in an ATP/ubiquitin-depend\nent nonlysosomal proteolytic pathway. eukary: the proteasome\n is composed of ~24 subunits forming a ring-shaped structure\n,necessary for peptidyl glutamyl peptide hydrolyzing activit\ny , proteasome subunit,Null mutant is inviable\n mYHR138C:Unknown ,, Unknown\n mPRE5:alpha-type of subunit of 20S proteasome,20S proteasome alpha\n-type subunit,Null mutant is inviable\n mPRE7:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mPRE9:proteasome component Y13,proteasome component Y13,\n mSGT2:small glutamine-rich tetratricopeptide repeat containing pro\ntein,,\n Cond882:zero3\n mALD2:Expression induced in response to high osmotic stress. NAD+ \nis preferred coenzyme.,aldeyhde dehydrogenase,ald2 ald3 doub\nle mutants show reduced growth rate with ethanol as the sole\n carbon source.\n mYGL047W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mYMR090W:Unknown ,, Unknown\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n mAHA1:Unknown ,, Unknown\n mGLO1:Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-act\nivated protein) kinase pathway in osmotic stress response,la\nctoylglutathione lyase (glyoxalase I),Null mutant is viable;\n sensitive to methylglyoxal\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n Cond349:1_mM_Menadione_(50_min)redo\n Cond372:1.5_mM_diamide_(30_min)\n mRBK1:ribokinase,ribokinase,\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNK1:Nucleoside diphosphate kinase,nucleoside diphosphate kinase,\nNull mutant is viable, exhibits no defects in growth rate, s\npore formation, mating ability, or morphology\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n Cond324:heat_shock_33_to_37,_20_minutes\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n Cond380:1M_sorbitol_-_45_min_\n mEMI1:Unknown ,, Unknown\n mUBI4:involved in stress response system,ubiquitin,Null mutant is \nviable, grows at wild-type rates and contains wild-type leve\nls of free ubiquitin under exponential growth conditions, hy\npersensitive to high temperatures, starvation and amino acid\n analogs; although ubi4/UBI4 diploids form initially viable \nspores, the two ubi4 spores lose viability extremely rapidly\n; homozygous ubi4/ubi4 diploids are sporulation defective\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mYOL032W:Unknown ,, Unknown\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mYBR062C:Unknown ,, Unknown\n mYOR289W:Unknown ,, Unknown\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond304:Heat_Shock_30_minutes_hs-1\n mYNL155W:Unknown ,, Unknown\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mCDC37:cell cycle protein necessary for passage through START,,Null\n mutant is inviable; temperature-sensitive mutants arrest in\n G1 and form shmoo morphology at the restrictive temperature\n mHIS5:responsive to control of general amino acid biosynthesis,his\ntidinol-phosphate aminotransferase,Null mutant is viable and\n requires histidine\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYOL083W:Unknown ,, Unknown\n mVPS73:Unknown ,, Unknown\n mTFS1:(putative) lipid binding protein; supressor of a cdc25 mutat\nion,lipid binding protein (putative) , supressor of a cdc25 \nmutation,Null mutant is viable.\n mYNL156C:Unknown ,, Unknown\n mMCH4:Unknown ,, Unknown\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mYHL021C:Unknown ,, Unknown\n mGGA1:Golgi-localized, gamma-adaptin homology, Arf-binding,ARF-bin\nding protein,\n mYBR230C:Unknown ,, Unknown\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n mCVT19:Cytoplasm to Vacuole Targeting; Mutant is defective in impor\nt of aminopeptidase I through the cytoplasm to vacuole targe\nting pathway,Receptor for biosynthetic cytoplasm to vacuole \ntargeting,Null: viable, unable to target vacuolar aminopepti\ndase I and to vacuoles, both under growing and nitrogen star\nvation conditions.\n Cond674:DES459_(mec1)_+_heat_20_min\n mTSL1:123 kD regulatory subunit of trehalose-6-phosphate synthase/\nphosphatase complex; homologous to TPS3 gene product,similar\n to TPS3 gene product , trehalose-6-phosphate synthase/phosp\nhatase complex 123 kDa regulatory subunit,Null mutant is via\nble\n Cond373:1.5_mM_diamide_(40_min)\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n Cond802:CaFK30'\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n Cond376:1.5_mM_diamide_(90_min)\n mYHR112C:Unknown ,, Unknown\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mYBR056W:Unknown ,, Unknown\n mRPN11:Suppressor of mutant (ts on glycerol) tRNA gene deficient in\n the processing of its 3'-end; homologous to S. pombe PAD1 g\nene - global positive regulator of nuclear transcription and\n is involved in maintenance of chromatin structure,,Null mut\nant is inviable\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mYFL057C:Unknown ,, Unknown\n mCOQ5:co-enzyme Q deficient,C-methyltransferase (putative),Null mu\ntant is viable, respiratory deficient, petite.\n mMRF1':May be transcriptional regulator of genes involved in assemb\nly of mitochondrial respiratory proteins,binds to T-rich str\nand of core consensus sequence of autonomously replicating s\nequence,Null mutant is viable but is respiratory-deficient\n mYJL161W:Unknown ,, Unknown\n mYOR052C:Unknown ,, Unknown\n Cond797:Ca15'\n mGLC8:Homolog of mammalian protein phosphatase inhibitor 2,protein\n phosphatase 1 (Glc7p) regulator,Null mutant is viable; dele\ntion of glc8 suppresses phenotypes of ipl1 and glc7 mutants\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mYCR102C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSDS22:Interacts with and may be a positive regulator of GLC7 which\n encodes type1 protein phosphatase,Glc7p regulatory subunit,\nNull mutant is inviable, lethality can be resuced by overexp\nression of GLC7\n mYLR327C:Unknown ,, Unknown\n mPUP2:Proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n Cond374:1.5_mM_diamide_(50_min)\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n mRNY1:RiboNuclease from Yeast,ribonuclease, T2 family,\n Cond366:dtt_120_min_dtt-2\n mRIM11:Required for Ime1p phosphorylation, association of the Ime1p\n-Ume6p meiotic activator, early meiotic gene expression, and\n sporulation,,Null mutant is viable; some alleles are Spo+ a\nnd sporulate slowly; rim11 is epistatic to the lethality of \nIME1 overexpression in haploids and permits Ime1p accumulati\non; RIM11 is a high copy suppressor of mck1 (cs) mutants\n mYKL091C:Unknown ,, Unknown\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n mHSC82:constitutively expressed heat shock protein,chaperonin,Null \nmutant is viable at 25 degrees C; ability to grow at higher \ntemperatures varies with gene copy number\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n Cond652:wt_plus_gamma_20_min\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n Cond369:1.5_mM_diamide_(5_min)\n mYDR533C:Unknown ,, Unknown\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mEMP46:Unknown ,, Unknown\n mECM4:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n mGPX2:Glutathione peroxidase paralogue,,Null mutant is viable\n mDCS1:Unknown ,, Unknown\n mDCS2:Unknown ,, Unknown\n mYBL064C:Unknown ,, Unknown\n Cond375:1.5_mM_diamide_(60_min)\n Cond323:heat_shock_29_to_37,_20_minutes\n mERO1:involved in protein disulfide bond formation in the ER,,Null\n mutant is inviable; in ero1-1(ts) mutants newly synthesized\n carboxypeptidase Y is retained in the ER and lacks disulfid\ne bonds; ero1 mutants are hypersensitive to to the reductant\n DTT, whereas overexpression of ERO1 confers resistance to D\nTT, the oxidant diamide can restore growth and secretion in \nero1 mutants\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mTSA2:Unknown ,, Unknown\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n Cond346:1_mM_Menadione_(20_min)_redo\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mYLR387C:Unknown ,, Unknown\n mAYR1:Subcellular location of Ayr1p: lipid particles and endoplasm\nic reticulum of the yeast,1-acyl dihydroxyacetone phosphate \nreductase,Null mutant is viable\n mGSP2:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein , Gsp1p homolog,Null mutant is viable\n mYDR330W:Unknown ,, Unknown\n Cond340:constant_0.32_mM_H2O2_(60_min)_redo\n Cond379:1M_sorbitol_-_30_min\n mYDL023C:Unknown ,, Unknown\n mHXK1:Glucose phosphorylation,hexokinase I (PI) (also called hexok\ninase A),Null mutant is viable, is able to ferment fructose,\n and has little or no effect on glucose repression; hxk1, hx\nk2 double null mutant cannot ferment fructose and fails to s\nhow glucose repression at SUC2, CYC1, GAL10\n mYHR029C:Unknown ,, Unknown\n mSOD1:Cu, Zn superoxide dismutase,Cu, Zn superoxide dismutase,Null\n mutant is viable; dioxygen and paraquat sensitive; fails to\n grow on lactate as a carbon source; exhibits increased copp\ner sensitivity; exhibits slower proliferation time due to in\ncreased length of G1; methionine auxotroph and oxygen sensit\nive; SOD1 is required for sporulation\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond434:DBY7286_37degree_heat_-_20_min\n mCPR6:a cyclophilin related to the mammalian CyP-40; physically in\nteracts with RPD3 gene product,cyclophilin 40 , peptidyl-pro\nlyl cis-trans isomerase (PPIase),Null mutant is viable, has \nnormal growth rate\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n Cond783:Peroxide_60'\n mUGA1:gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate ami\nnotransferase),gamma-aminobutyrate (GABA) transaminase (4-am\ninobutyrate aminotransferase),\n mYML131W:Unknown ,, Unknown\n mUGA2:involved in utilization of GABA as a nitrogen source,succina\nte semialdehyde dehydrogenase,Null mutant is viable but cann\not grow with GABA as the only nitrogen source.\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n mUFD1:Ubiquitin fusion degradation protein,,Homozygous ufd1-1 muta\nnt diploids exhibit sporulation defects.\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mCOX5B:Cytochrome-c oxidase chain Vb,cytochrome c oxidase chain Vb,\nNull mutant is viable\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mUBP6:deubiquitinating enzyme (putative),,\n mYPL004C:Unknown ,, Unknown\n Cond876:zero2\n mISU2:Iron-sulfur cluster nifU-like protein,,Null mutant is viable\n on YPD at 30 degrees C, and is synthetically lethal with is\nu1 null.\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n mYJR096W:Unknown ,, Unknown\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mSTF2:ATPase stabilizing factor,ATPase stabilizing factor,\n mYLR345W:Unknown ,, Unknown\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mHSP42:Similar to HSP26; expression is regulated by stress conditio\nns,,Null mutant is viable; hsp42 hsp26 double deletion mutan\nts are viable; hsp42 null mutants subjected to moderate ther\nmal stress reorganize the actin cytoskeleton more slowly tha\nn wild-type\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mBTN2:Gene/protein whose expression is elevated in a btn1 minus/Bt\nn1p lacking yeast strain.,,Null mutant is viable; expression\n of BTN2 is elevated in yeast lacking BTN1\n
mPEP12:integral membrane protein; c-terminal TMD; located in endoso\nme,c-terminal TMD , integral membrane protein , c-terminal T\nMD , integral membrane protein , c-terminal TMD , integral m\nembrane protein,proteinase deficient\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond944:SK1_ume6_YPA\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n Cond798:Ca30'\n mPPM1:carboxy methyl transferase for protein phosphatase 2A cataly\ntic subunit,carboxy methyl transferase for protein phosphata\nse 2A catalytic subunit,Mutant is rapamycin resistant, benom\nyl supersensitive, and nocodazole sensitive.\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mYOL048C:Unknown ,, Unknown\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mHNT2:Fhit homolog, member of the histidine triad superfamily of n\nucleotide binding-proteins,,\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mCVT19:Cytoplasm to Vacuole Targeting; Mutant is defective in impor\nt of aminopeptidase I through the cytoplasm to vacuole targe\nting pathway,Receptor for biosynthetic cytoplasm to vacuole \ntargeting,Null: viable, unable to target vacuolar aminopepti\ndase I and to vacuoles, both under growing and nitrogen star\nvation conditions.\n mYOR131C:Unknown ,, Unknown\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mSSP120:secretory protein,,Null mutant is viable\n Cond802:CaFK30'\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n mYKL206C:Unknown ,, Unknown\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mYOR059C:Unknown ,, Unknown\n mRPN11:Suppressor of mutant (ts on glycerol) tRNA gene deficient in\n the processing of its 3'-end; homologous to S. pombe PAD1 g\nene - global positive regulator of nuclear transcription and\n is involved in maintenance of chromatin structure,,Null mut\nant is inviable\n Cond894:G2\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mRPN13:Proteasome subunit,,Null mutant is viable but defective in d\negradation of ubiquitinated substrates.\n mYIM1:Mitochondrial inner membrane protease, similar to E. coli le\nader peptidase,protease , similar to E. coli leader peptidas\ne,\n mYDR196C:Unknown ,, Unknown\n mYGR111W:Unknown ,, Unknown\n mRET3:vesicle coat component,vesicle coat component,ret3-1 mutant \nis thermosensitive and shows defects in retrieval of dilysin\ne-tagged proteins from the Golgi back to the ER\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n Cond879:MMC\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mYGR207C:Unknown ,, Unknown\n mYPR148C:Unknown ,, Unknown\n mAPS1:Involved in a subset of clathrin functions at the Golgi,clat\nhrin associated protein complex small subunit,Null mutant is\n viable; aps1 mutants demonstrate synthetic effects with chc\n1 alleles\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPUP2:Proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mYFR003C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n mYGL117W:Unknown ,, Unknown\n mTFG2:transcription initiation factor TFIIF middle subunit,transcr\niption initiation factor TFIIF middle subunit,Null mutant is\n inviable\n Cond881:4NQO\n mYOR220W:Unknown ,, Unknown\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond564:alpha91\n Cond347:1_mM_Menadione_(30_min)_redo\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n mTOS5:Hypothetical ORF,,\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n Cond896:STAT\n mIKS1:ira1* kinase suppressor,serine/threonine kinase (putative),N\null mutant is heat shock sensitive\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mYPR1:homologous to the aldo-keto reductase protein family,,\n mYET1:Yeast BAP31 homolog,yeast endoplasmic reticulum 25 kDa trans\nmembrane protein,Null mutant is viable\n mHRT1:High level expression Reduces Ty3 Transposition,Skp1-Cullin-\nF-box ubiquitin protein ligase (SCF) subunit,Null mutant is \ninviable.\n mDCS1:Unknown ,, Unknown\n Cond898:RPN4\n mYNL181W:Unknown ,, Unknown\n Cond371:1.5_mM_diamide_(20_min)\n mVPS45:Protein of the Sec1p family essential for vacuolar protein s\norting,,Null mutant is viable, defective in the segregation \nof vacuolar material into the developing daughter cell, has \nlarge central vacuoles\n Cond375:1.5_mM_diamide_(60_min)\n Cond940:6h\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR387C:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond893:SMMS\n mRPN9:Regulatory Particle Non-ATPase,proteasome regulatory particl\ne subunit,Null mutant is viable, temperature sensitive; rpn9\n rpn10 double deletion mutants are viable\n Cond379:1M_sorbitol_-_30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mNMA2:Unknown ,, Unknown\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n mPRE4:B-type subunit of proteasome, euk. & archae. multicatalytic \nproteinase complex likelyinvolved in an ATP/ubiquitin-depend\nent nonlysosomal proteolytic pathway. eukary: the proteasome\n is composed of ~24 subunits forming a ring-shaped structure\n,necessary for peptidyl glutamyl peptide hydrolyzing activit\ny , proteasome subunit,Null mutant is inviable\n mTLG2:member of the syntaxin family of t-SNAREs,tSNARE that affect\ns a late Golgi compartment,Null mutant is viable in SEY6210,\n exhibits endocytosis defect and loss of Kex2p\n mYHR138C:Unknown ,, Unknown\n Cond434:DBY7286_37degree_heat_-_20_min\n mATR1:aminotriazole resistance,very hydrophobic, has many membrane\n-spanning regions, several potential glycosylation sites, po\ntential ATP-binding site,Null mutant is viable, but is sensi\ntive to very low (5 mM) levels of aminotriazole and to 4-nit\nroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer \nhyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 b\nackground confer resistance to high (80mM) levels of aminotr\niazole\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast.  Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mIST1:Similar to Nuf1p (spindle pole body component),,\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mPRE9:proteasome component Y13,proteasome component Y13,\n Cond783:Peroxide_60'\n Cond895:G2MMS\n mUFD1:Ubiquitin fusion degradation protein,,Homozygous ufd1-1 muta\nnt diploids exhibit sporulation defects.\n mYPR158W:Unknown ,, Unknown\n Cond882:zero3\n Cond877:MMS\n Cond875:60min\n mYMR090W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n Cond886:g-ray\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mGRE3:Induced by osmotic stress; similar to xylose reductase from \nother fungi,,\n mDOA1:Required for normal intracellular ubiquitin metabolism and f\nor normal rates of proteolysis of ubiquitin-dependent proteo\nlytic substrates in vivo,,Null mutant is viable and defectiv\ne in degradation of ubiquitinated proteins; homozygous null \ndiploid shows sporulation defect\n mUBP6:deubiquitinating enzyme (putative),,\n mVPS60:vacuolar protein sorting (putative),,Null mutant is viable b\nut a class E vps mutant (missorts vacuolar hydrolases and ac\ncumulates late endosomal compartment).\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n mYFL061W:Unknown ,, Unknown\n Cond885:20\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mARC18:Arp2/3 complex subunit,,\n Cond348:1mM_Menadione_(40_min)_redo\n mYJR096W:Unknown ,, Unknown\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mYKT6:Synaptobrevin (v-SNARE) homolog with similarity to Sec22p, S\nnc1p, and Snc2p, essential for endoplasmic reticulum-Golgi t\nransport,v-SNARE,Null mutant is inviable. Depletion of Ykt6p\n results in the accumulation of the p1 precursor (endoplasmi\nc reticulum form) of the vacuolar enzyme carboxypeptidase Y \nand morphological abnormalities consistent with a defect in \nsecretion.\n mYMR041C:Unknown ,, Unknown\n mYPT52:rab5-like GTPase involved in vacuolar protein sorting and en\ndocytosis,,Null mutant is viable; ypt51 ypt52 double deletio\nn exacerbates the temperature sensitivity and vacuolar prote\nin sorting defects of ypt51 deletion\n mFYV10:Function required for Yeast Viability on toxin exposure,,Nul\nl mutant is viable but exhibits K1 killer toxin hypersensiti\nvity.\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mYNL155W:Unknown ,, Unknown\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mNPL4 mUFD1 mRPT2 mRPN5 mRPT3 mRPN9 mRPN12 mRPT1 mRPN8 mRPN11 mRPT5 mRPT4 mRPT6 mHRT1 mPRE1 mSCL1 mPRE9 mPUP2 mPRE3 mYKL206C mPRE10 mVPS45 mTLG2 mPEP12 mLAP4 mCVT19
mCDC37:cell cycle protein necessary for passage through START,,Null\n mutant is inviable; temperature-sensitive mutants arrest in\n G1 and form shmoo morphology at the restrictive temperature\n mYDR071C:Unknown ,, Unknown\n Cond798:Ca30'\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mUBC13:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n mGGA1:Golgi-localized, gamma-adaptin homology, Arf-binding,ARF-bin\nding protein,\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYDR391C:Unknown ,, Unknown\n mUMP1:Involved in ubiquitin-mediated proteolysis,20S proteasome ma\nturation factor,Null mutant is viable, grows slower than wil\nd-type, is hypersensitive to cadmium ions and canavanine, ac\ncumulates Ub-protein conjugates; ump1 null homozygous diploi\nds fail to sporulate\n mUBC1:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable but exhibit moderately slow growth.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mPST2:Protoplasts-SecreTed protein; the gene product was detected \namong the proteins secreted by regenerating protoplasts,,\n Cond373:1.5_mM_diamide_(40_min)\n mUBC5:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,vi\nable, ubc4/ubc5 double mutant is temperature sensitive\n mMAG1:3-methyladenine DNA glycosylase,3-methyladenine DNA glycosyl\nase,Null mutant is viable, deficient in 3-methyladenine DNA \nglycosylase activity and shows enhanced sensitivity to sever\nal monofunctional alkylating agents\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n mGAD1:glutamate decarboxylase,glutamate decarboxylase,\n Cond802:CaFK30'\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond376:1.5_mM_diamide_(90_min)\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mCDC53:acts together with Cdc4p and Cdc34p to control the G1-S phas\ne transition, assists in mediating the proteolysis of the Cd\nk inhibitor Sic1p in late G1,,Cells arrest in G1 with active\n Cln kinases but no Clb-associated Cdc28p kinase activity\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n mDOS2:Product of gene unknown,,\n mYDL027C:Unknown ,, Unknown\n Cond797:Ca15'\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mSDS22:Interacts with and may be a positive regulator of GLC7 which\n encodes type1 protein phosphatase,Glc7p regulatory subunit,\nNull mutant is inviable, lethality can be resuced by overexp\nression of GLC7\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYFR003C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mRIB5:Riboflavin biosynthesis,,Null mutant is viable, exhibits rib\noflavin auxotrophy\n Cond366:dtt_120_min_dtt-2\n mYBR204C:Unknown ,, Unknown\n mARN1:Product of gene unknown,,\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mYJL032W:Unknown ,, Unknown\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n mBMH2:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mFLR1:Fluconazole Resistance 1,major facilitator transporter,Null \nmutant is viable; overexpression confers resistance to fluco\nnazole, cycloheximide, 4-nitroquinoline N-oxide\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond801:CaFK15'\n mYDL180W:Unknown ,, Unknown\n mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mHSP82:82 kDa heat shock protein; homolog of mammalian Hsp90,heat s\nhock protein 90 , mammalian Hsp90 homolog , heat shock prote\nin 90 , mammalian Hsp90 homolog,Null mutant is viable at 25 \ndegrees C; ability to grow at higher temperatures varies wit\nh gene copy number\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n mYMR067C:Unknown ,, Unknown\n mTRR1:Thioredoxin reductase,thioredoxin reductase,Null mutant is v\niable but grow slowly; trr1 mutations are sensitive to hydro\ngen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi\n4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6\n null mutants.\n mYDL072C:Unknown ,, Unknown\n Cond982:pho85D_10_mM_1NaPP1_\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYDR031W:Unknown ,, Unknown\n mAAD3:high degree of similarity with the AAD of P. chrysosporium,a\nryl-alcohol dehydrogenase (putative),\n mYDR533C:Unknown ,, Unknown\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mYPR1:homologous to the aldo-keto reductase protein family,,\n Cond800:CaFK5'\n Cond680:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison_,\n2\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mGTT2:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive in stationary phase\n Cond371:1.5_mM_diamide_(20_min)\n Cond375:1.5_mM_diamide_(60_min)\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mVTI1:Involved in cis-Golgi membrane traffic,interacts with two t-\nSNARES, Sed5p and Pep12p , v-SNARE,Null mutant is inviable\n mYDR003W:Unknown ,, Unknown\n mTSA2:Unknown ,, Unknown\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond346:1_mM_Menadione_(20_min)_redo\n mYMR315W:Unknown ,, Unknown\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mGSP2:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein , Gsp1p homolog,Null mutant is viable\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mRPN4:involved in ubiquitin degradation pathway,,Null mutant is vi\nable, exhibits synthetic interactions with sen3, sun1, and c\ndc28-1N\n mYDL124W:Unknown ,, Unknown\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mYDR330W:Unknown ,, Unknown\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n mARP2:Involved in endocytosis and membrane growth and polarity,act\nin related protein,Null mutant is inviable\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n mRPN9:Regulatory Particle Non-ATPase,proteasome regulatory particl\ne subunit,Null mutant is viable, temperature sensitive; rpn9\n rpn10 double deletion mutants are viable\n Cond379:1M_sorbitol_-_30_min\n mYDL023C:Unknown ,, Unknown\n mHXK1:Glucose phosphorylation,hexokinase I (PI) (also called hexok\ninase A),Null mutant is viable, is able to ferment fructose,\n and has little or no effect on glucose repression; hxk1, hx\nk2 double null mutant cannot ferment fructose and fails to s\nhow glucose repression at SUC2, CYC1, GAL10\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE1:Required for mitotic division and sporulation,22.6 kDa prote\nasome subunit,Null mutant is inviable, pre1 mutants accumula\nte ubiquitin-protein conjugates\n mCPR1:cyclophilin peptidyl-prolyl cis-trans isomerase,cyclophilin \n, peptidyl-prolyl cis-trans isomerase (PPIase) , cyclophilin\n , peptidyl-prolyl cis-trans isomerase (PPIase),Null mutant \nis viable\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRE9:proteasome component Y13,proteasome component Y13,\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mSGT2:small glutamine-rich tetratricopeptide repeat containing pro\ntein,,\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mTPK1:putative catalytic subunit of cAMP-dependent protein kinase,\ncAMP-dependent protein kinase catalytic subunit (putative),m\nulticopy suppression of ras mutant\n mTPK2:Involved in nutrient control of cell growth and division,cAM\nP-dependent protein kinase catalytic subunit,Null mutant hap\nloids are defective for invasive growth; diploid homozygous \nnull mutants are defective for pseudohyphal growth.\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mSLF1:Associates with translating ribosomes; may function in cytop\nlasm to modulate mRNA translation; regulates the copper-depe\nndent mineralization of copper sulfide complexes on cell sur\nface in cells cultured in medium containing copper salts,,Nu\nll mutant is viable, copper sensitive, has lost ability to d\neplete Cu, but not Cd ions from surrounding medium; SLF1 ove\nrexpression confers copper superresistance and enhances Ca d\nepletion ability\n mCOX5B:Cytochrome-c oxidase chain Vb,cytochrome c oxidase chain Vb,\nNull mutant is viable\n mAHA1:Unknown ,, Unknown\n mGLO1:Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-act\nivated protein) kinase pathway in osmotic stress response,la\nctoylglutathione lyase (glyoxalase I),Null mutant is viable;\n sensitive to methylglyoxal\n mSFA1:Long-chain alcohol dehydrogenase (glutathione-dependent form\naldehyde dehydrogenase),glutathione-dependent formaldehyde d\nehydrogenase , long-chain alcohol dehydrogenase,Null mutant \nis viable; sensitive to formaldehyde\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mSLU7:involved in 3' splice site choices and 2nd step of splicing,\n,Null mutant is inviable; synthetically lethal with prp16, p\nrp18 and U2 snRNA (LSR1); blocks pre-mRNA splicing in vivo a\nnd in vitro\n Cond372:1.5_mM_diamide_(30_min)\n mYNK1:Nucleoside diphosphate kinase,nucleoside diphosphate kinase,\nNull mutant is viable, exhibits no defects in growth rate, s\npore formation, mating ability, or morphology\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n mVPS68:Unknown ,, Unknown\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n mGPD1:glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehy\ndrogenase,lethal under conditions of osmotic stress, unable \nto grow on glycerol\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mYLR345W:Unknown ,, Unknown\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mHSP42:Similar to HSP26; expression is regulated by stress conditio\nns,,Null mutant is viable; hsp42 hsp26 double deletion mutan\nts are viable; hsp42 null mutants subjected to moderate ther\nmal stress reorganize the actin cytoskeleton more slowly tha\nn wild-type\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mYDL025C:Unknown ,, Unknown\n mBTN2:Gene/protein whose expression is elevated in a btn1 minus/Bt\nn1p lacking yeast strain.,,Null mutant is viable; expression\n of BTN2 is elevated in yeast lacking BTN1\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mARR4:Unknown ,, Unknown\n
mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mCDC37:cell cycle protein necessary for passage through START,,Null\n mutant is inviable; temperature-sensitive mutants arrest in\n G1 and form shmoo morphology at the restrictive temperature\n Cond368:dtt_480_min_dtt-2\n Cond982:pho85D_10_mM_1NaPP1_\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond654:wt_plus_gamma_45_min\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n Cond185:ubr2\n mGPX2:Glutathione peroxidase paralogue,,Null mutant is viable\n Cond680:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison_,\n2\n mUBC1:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable but exhibit moderately slow growth.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n Cond719:t4-SSD1\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n Cond940:6h\n Cond802:CaFK30'\n Cond:\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n Cond713:t4+Vec\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mDDI1:DNA Damage Inducible; binds to T- and V- snare complexes,,Nu\nll mutant is viable\n Cond346:1_mM_Menadione_(20_min)_redo\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond677:DES459_(mec1)_-_log_phase_(IR_time_=_0_sample)\n mRPN11:Suppressor of mutant (ts on glycerol) tRNA gene deficient in\n the processing of its 3'-end; homologous to S. pombe PAD1 g\nene - global positive regulator of nuclear transcription and\n is involved in maintenance of chromatin structure,,Null mut\nant is inviable\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n Cond722:t2+SSD1,H44\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n Cond379:1M_sorbitol_-_30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mCDC53:acts together with Cdc4p and Cdc34p to control the G1-S phas\ne transition, assists in mediating the proteolysis of the Cd\nk inhibitor Sic1p in late G1,,Cells arrest in G1 with active\n Cln kinases but no Clb-associated Cdc28p kinase activity\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDOS2:Product of gene unknown,,\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTFB3:Transcription/repair factor TFIIH subunit,TFIIH subunit,Null\n mutant is inviable\n mPRE9:proteasome component Y13,proteasome component Y13,\n Cond716:t2+SSD1wt\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n mYDL099W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond236:yjl107c(haploid)\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSLF1:Associates with translating ribosomes; may function in cytop\nlasm to modulate mRNA translation; regulates the copper-depe\nndent mineralization of copper sulfide complexes on cell sur\nface in cells cultured in medium containing copper salts,,Nu\nll mutant is viable, copper sensitive, has lost ability to d\neplete Cu, but not Cd ions from surrounding medium; SLF1 ove\nrexpression confers copper superresistance and enhances Ca d\nepletion ability\n mYHB1:may play a role in the oxidative stress response,flavohemogl\nobin,Null mutant is viable. A rho+ strain carrying a yhb1(-)\n deletion has normal levels of both cyanide-sensitive and cy\nanide-insensitive respiration. Cells that carry a yhb1(-) de\nletion are sensitive to conditions that promote oxidative st\nress.\n Cond349:1_mM_Menadione_(50_min)redo\n Cond374:1.5_mM_diamide_(50_min)\n Cond715:t0-SSD1\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n Cond351:1_mM_Menadione_(105_min)_redo\n Cond555:alpha28\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond564:alpha91\n Cond347:1_mM_Menadione_(30_min)_redo\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n Cond710:t2+SSD1\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n Cond939:4h\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mRPT2 mRPN5 mRPT3 mRPN12 mRPT1 mRPN3 mRPN11

this is an automaticly generated GENESYS report
Computational Genomics Lab, Tel-Aviv uniresity