Module ergosterol_metabolism




Database revision : gnsdb28.10
Date : Fri Feb 28 01:36:31 2003
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mERG11:cytochrome P450 lanosterol 14a-demethylase,cytochrome P450 l\nanosterol 14a-demethylase,Null mutant is inviable, erg11 nul\nl inviability is suppressed by deletion of ERG3; erg11 mutan\nts are ergosterol biosynthesis defective; many are also nyst\natin resistant\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mYJL048C:Unknown ,, Unknown\n mYDR492W:Unknown ,, Unknown\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG3:C-5 sterol desaturase,C-5 sterol desaturase,Null mutant is i\nnviable; suppresses syringomycin resistant mutant\n mYEL033W:Unknown ,, Unknown\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mERG7:carries out complex cyclization step of squalene to lanoster\nol in sterol biosynthesis pathway,2,3-oxidosqualene-lanoster\nol cyclase,Null mutant is inviable\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond218:yer066c-a\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mERG26:C-3 sterol dehydrogenase,C-3 sterol dehydrogenase,\n mERG28:Transmembrane domain containing protein which may facilitate\n protein-protein interactions between the Erg26p dehydrogena\nse and the Erg27p 3-ketoreductase and/or to tether these enz\nymes to the ER,,Null mutant is viable; random budding in dip\nloid null mutants; null cells have an unusual sterol content\n.\n mYGL188C:Unknown ,, Unknown\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n mHMX1:Unknown ,, Unknown\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYGR176W:Unknown ,, Unknown\n mCYC1:iso-1-cytochrome c,iso-1-cytochrome c,Cytochrome c deficienc\ny\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mRIP1:oxidizes ubiquinol at center P in the protonmotive Q cycle m\nechanism, transferring one electron to cytochrome c1 and gen\nerating a low-potential ubisemiquinone anion which reduces t\nhe low-potential cytochrome b-566 heme group,Rieske iron-sul\nfur protein of the mitochondrial cytochrome bc1 complex,Null\n mutant is viable, unable to grow on nonfermentable carbon s\nources\n mCOX12:essential during assembly for full cytochrome c oxidase acti\nvity,cytochrome c oxidase subunit VIb,Null mutant is viable,\n grows poorly at room temperature, fails to grow on glycerol\n/ethanol media at 37 degrees\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n mHYP2:Translation initiation factor eIF-5A,translation initiation \nfactor eIF-5A,Null mutant is viable; a double mutant contain\ning disruptions of both HYP2 and and the highly homologous A\nNB1 is inviable\n mNDE1:Unknown ,, Unknown\n mYMR134W:Unknown ,, Unknown\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond877:MMS\n mYKR046C:Unknown ,, Unknown\n mACS2:one of 2 acetyl-coA synthetases in yeast,acetyl CoA syntheta\nse,Null mutant is viable, and grows on ethanol or acetate as\n sole carbon source, but is unable to grow on glucose as sol\ne carbon source; acs1 acs2 double null mutant is inviable\n mSNO1:SNZ1 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable, sensitive to 6-azauracil and methylene blue.\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n Cond571:cdc15_50\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond294:Itraconazole\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond570:cdc15_30\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mCYT1:Cytochrome c1,cytochrome c1,\n
Cond899:RPN4_MMS__\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n Cond878:MNNG\n Cond895:G2MMS\n mHYP2:Translation initiation factor eIF-5A,translation initiation \nfactor eIF-5A,Null mutant is viable; a double mutant contain\ning disruptions of both HYP2 and and the highly homologous A\nNB1 is inviable\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Cond879:MMC\n mNDE1:Unknown ,, Unknown\n mRPB10:RNA polymerase II subunit,RNA polymerase II core subunit,Nul\nl mutant is inviable\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond385:Hypo-osmotic_shock_-_15_min\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond875:60min\n mYDR492W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mDBP3:ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family,A\nTP dependent RNA helicase , dead/deah box protein CA3,Null m\nutant is viable\n Cond886:g-ray\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNL211C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mRPL35A:Homology to rat L35,ribosomal protein L35A,Null mutant is vi\nable.\n Cond883:5\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mERG7:carries out complex cyclization step of squalene to lanoster\nol in sterol biosynthesis pathway,2,3-oxidosqualene-lanoster\nol cyclase,Null mutant is inviable\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond876:zero2\n Cond890:G1\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond885:20\n Cond889:4NQO_2\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond881:4NQO\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond894:G2\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n Cond636:DES460_+_0.2%_MMS_-_45_min\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mYOL002C:Unknown ,, Unknown\n mHMX1:Unknown ,, Unknown\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond893:SMMS\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mIDI1:catalyzes activation step in isoprenoid biosynthetic pathway\n,isopentenyl diphosphate:dimethylallyl diphosphate isomerase\n (IPP isomerase),Null mutant is inviable\n Cond884:10\n
Cond281:HMG2(tetpromoter)\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n Cond912:(99i1)_S150-2B_YPGL_NormInt\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n RapamycinHap.hap_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins.  Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond654:wt_plus_gamma_45_min\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns.  J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond487:pho80_vs_WT\n Cond188:vma8\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG3:C-5 sterol desaturase,C-5 sterol desaturase,Null mutant is i\nnviable; suppresses syringomycin resistant mutant\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mERG6:ergosterol synthesis,,The null mutant is viable, cannot meth\nylate ergosterol precursors at C-24, and lacks ergosterol. T\nhe null mutant shows defective conjugation, diminished capac\nity for transformation, and defective tryptophan uptake. The\n null mutant is hypersensitive to cycloheximide, Li+, and Na\n+, sensitive to anthracyclines, dactinomycin, and bretfeldin\n A, and resistant to nystatin.\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond445:Msn4_overexpression\n Cond53:erg2\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond916:(99i5)__HBY4_YPGL+G_NormInt\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mERG26:C-3 sterol dehydrogenase,C-3 sterol dehydrogenase,\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles.  Science. 200\n0 Feb 4;287(5454):873-80\n mERG27:3-keto sterol reductase,3-keto sterol reductase,\n mERG28:Transmembrane domain containing protein which may facilitate\n protein-protein interactions between the Erg26p dehydrogena\nse and the Erg27p 3-ketoreductase and/or to tether these enz\nymes to the ER,,Null mutant is viable; random budding in dip\nloid null mutants; null cells have an unusual sterol content\n.\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond568:alpha119\n Cond937:t=0\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond900:(11i1)_S150-2B_YPGL_NormInt\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n Cond279:ERG11(tetpromoter)\n Cond420:YPD_3_d_ypd-2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond910:(83i4)_S150-2B_YPGL+G_NormInt\n Cond489:PHO81c_vs_WT_exp1\n Cond689:gal3+gal\n Cond852:30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n Cond569:cdc15_10\n Cond851:15_min\n Cond694:gal10+gal\n Cond490:PHO81c_vs_WT_exp2_\n mYLR101C:Unknown ,, Unknown\n Cond936:12h\n mYDL038C:Unknown ,, Unknown\n Cond625:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y12-121\n mYMR134W:Unknown ,, Unknown\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network.  Science. 2001 May 4;292(5518\n):929-34.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mPRM7:pheromone-regulated membrane protein,,\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n Cond483:Low-Pi_vs_High-Pi_in_WT_(NBW7)_exp1\n Cond571:cdc15_50\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond294:Itraconazole\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis.  Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond574:cdc15_90\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond295:Lovastatin\n Cond366:dtt_120_min_dtt-2\n Cond576:cdc15_110\n Cond659:DES460_(wt)_-_mock_irradiation_-_30_min\n Cond570:cdc15_30\n Cond636:DES460_+_0.2%_MMS_-_45_min\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond35:cup5\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond559:alpha56\n Cond540:fus3Dtec1Dą50nMaF,30minlog10(intensity)\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond665:mec1_plus_gamma_30_min\n Cond939:4h\n
Cond281:HMG2(tetpromoter)\n Cond368:dtt_480_min_dtt-2\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mYMR009W:Unknown ,, Unknown\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mASH1:Zinc-finger inhibitor of HO transcription which is asymmetri\ncally localized to the daughter cell nucleus,,Mutant ash1 da\nughters can transcribe HO and switch mating type\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns.  J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond487:pho80_vs_WT\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond971:swi1,_minimal_(d)_\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG3:C-5 sterol desaturase,C-5 sterol desaturase,Null mutant is i\nnviable; suppresses syringomycin resistant mutant\n Y-Stre.msn2/4acid:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n mERG8:Involved in isoprene and ergosterol biosynthesis pathways,48\n kDa phosphomevalonate kinase,Null mutant is inviable\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond890:G1\n Cond53:erg2\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond718:t4+SSD1wt\n Cond753: Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond888:MNNG_2\n Cond894:G2\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond893:SMMS\n Cond935:10h\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n Cond490:PHO81c_vs_WT_exp2_\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae.  Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n Cond879:MMC\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond963:t11.5_g/r_ratio\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n  Science. 1998 Oct 23;282(5389):699-705.\n Cond877:MMS\n Cond875:60min\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n Cond876:zero2\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond778:msn2/4_acid_10'\n Cond714:t0+SSD1wt\n Cond294:Itraconazole\n Cond885:20\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis.  Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n Cond881:4NQO\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n Cond636:DES460_+_0.2%_MMS_-_45_min\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond962:t9_g/r_ratio\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth.  Nature. 2000 Jul 6;406(6791):90-4.\n Cond884:10\n
PEX.Pex:Transcriptome profiling to identify genes involved in peroxi\nsome assembly and function.  J Cell Biol. 2002 Jul 22;158(2)\n:259-71.\n Cond281:HMG2(tetpromoter)\n Cond163:ssn6(haploid)\n mERG11:cytochrome P450 lanosterol 14a-demethylase,cytochrome P450 l\nanosterol 14a-demethylase,Null mutant is inviable, erg11 nul\nl inviability is suppressed by deletion of ERG3; erg11 mutan\nts are ergosterol biosynthesis defective; many are also nyst\natin resistant\n mYCR049C:Unknown ,, Unknown\n Cond221:yer083c\n mPLB1:Responsible for the production of the deacylation products o\nf phosphatidylcholine and phosphatidylethanolamine but not p\nhosphatidylinositol,phospholipase B (lypophospholipase),Null\n mutant is viable but releases greatly reduced levels of pho\nsphatidylcholine and phosphatidylethanolamine metabolites\n mUPC2:involved in sterol uptake,zinc finger transcription factor o\nf the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant\n is viable; upc2-1 allele shows altered sterol uptake\n mTIR1:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,\n Cond121:qcr2(haploid)\n mTIR2:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,Null mutant is viable.\n Cond188:vma8\n Cond363:dtt_015_min_dtt-2\n Cond730:hda1\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mERG6:ergosterol synthesis,,The null mutant is viable, cannot meth\nylate ergosterol precursors at C-24, and lacks ergosterol. T\nhe null mutant shows defective conjugation, diminished capac\nity for transformation, and defective tryptophan uptake. The\n null mutant is hypersensitive to cycloheximide, Li+, and Na\n+, sensitive to anthracyclines, dactinomycin, and bretfeldin\n A, and resistant to nystatin.\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n mYBR005W:Unknown ,, Unknown\n Cond53:erg2\n mYPR197C:Unknown ,, Unknown\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond840:expt3\n mYOR338W:Unknown ,, Unknown\n Cond218:yer066c-a\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n mDAN2:Delayed anaerobic gene,putative cell wall protein,unknown\n mDAN3:delayed anaerobic gene,putative cell wall protein,unknown\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond298:Terbinafine\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond489:PHO81c_vs_WT_exp1\n mYGR176W:Unknown ,, Unknown\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n Cond181:top3(haploid)\n Cond229:yhr011w(**14)\n mYPL282C:Unknown ,, Unknown\n Cond216:yer044c(haploid)\n mYGL261C:Unknown ,, Unknown\n mYAL068C:Unknown ,, Unknown\n mYLL025W:Unknown ,, Unknown\n mSNZ1:Snooze: stationary phase-induced gene family; may be involve\nd in cellular response to nutrient limitation and growth arr\nest,highly conserved 35 kDa protein that shows increased exp\nression after entry into stationary phase,Null mutant is via\nble, sensitive to 6-azauracil and methylene blue.\n Cond625:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y12-121\n mPAU2:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mPAU3:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n Cond54:erg3(haploid)\n mPAU4:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPAU5:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mYIL176C:Unknown ,, Unknown\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n mYPL272C:Unknown ,, Unknown\n mYJL213W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n Cond182:tup1(haploid)\n Cond483:Low-Pi_vs_High-Pi_in_WT_(NBW7)_exp1\n Cond294:Itraconazole\n mYDR542W:Unknown ,, Unknown\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis.  Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n Cond295:Lovastatin\n mYIR041W:Unknown ,, Unknown\n Cond299:Tunicamycin\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n  Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n mHES1:Protein implicated in ergosterol biosynthesis,similar to hum\nan oxysterol binding protein,pleiotropic sterol-related phen\notypes\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond274:yor080w(**3)\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond35:cup5\n mYLL012W:Unknown ,, Unknown\n mYHL046C:Unknown ,, Unknown\n

this is an automaticly generated GENESYS report
Computational Genomics Lab, Tel-Aviv uniresity