Module cell_wall_organization_and_biogenesis




Database revision : gnsdb28.10
Date : Fri Feb 28 01:36:31 2003
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Cond755: Cond663:mec1_plus_gamma_10_min\n Cond476:GCN4C/GCN4(R4760/R6257)\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond565:alpha98\n Cond548:cln3-2\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond751: Cond121:qcr2(haploid)\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond400:Nitrogen_Depletion_12_h\n Cond735: Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond579:cdc15_140\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Stress.WeakCold:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond724:t4+SSD1,H44\n Cond562:alpha77\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles.  Science. 200\n0 Feb 4;287(5454):873-80\n mCIS3:cik1 suppressor,similar to Hsp150p and Pir1p, Pir2p, and Pir\n3p,Null mutant is viable; CIS3 is a high copy suppressor of \ncik1 deletion mutants\n Cond376:1.5_mM_diamide_(90_min)\n Cond530:GAL-BNI1D,3hrs.gallog10(intensity)\n mCRH1:congo red hypersensitive,cell wall protein,Null mutant is vi\nable and hypersensitive to Congo Red and Calcofluor White\n Cond568:alpha119\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond897:STATMMS\n Cond894:G2\n Cond155:she4\n Cond279:ERG11(tetpromoter)\n Cond752: Cond404:Nitrogen_Depletion_5_d\n Cond61:fks1(haploid)\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n Cond580:cdc15_150\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond367:dtt_240_min_dtt-2\n Cond879:MMC\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond581:cdc15_160\n Cond54:erg3(haploid)\n Cond558:alpha49\n Cond572:cdc15_70\n Cond963:t11.5_g/r_ratio\n Cond68:gas1\n Cond52:erd1\n Cond9:ard1\n Cond328:33C_vs._30C_-_90_minutes\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond582:cdc15_170\n Cond314:Heat_Shock_060_minutes__hs-2\n Cond91:kim4\n Y-Stre.Alkali:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond691:gal5+gal\n Cond571:cdc15_50\n Cond92:kin3\n mPRY2:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n Cond737: Cond742: Cond366:dtt_120_min_dtt-2\n Cond754: Cond555:alpha28\n mMSB2:putative integral membrane protein,integral membrane protein\n (putative),multicopy suppressor of cdc24 ts mutation\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond964:ndt80_delete_early_g/r_ratio\n Cond564:alpha91\n Cond11:arg5,6\n Cond40:dig1,dig2\n Cond547:cln3-1\n Cond664:mec1_plus_gamma_20_min\n Cond423:YPD_stationary_phase_4_h_ypd-1\n Cond368:dtt_480_min_dtt-2\n Cond292:Glucosamine\n mTOS7:Hypothetical ORF,,\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond130:rml2(**13)\n Cond552:alpha7\n Cond93:kre1\n Cond280:FKS1(tetpromoter)\n Cond140:rps24a(**9)\n Cond892:S\n Cond519:rst1Drst2Dą50nMaF,30minlog10(intensity)\n Cond586:cdc15_210\n Cond28:cla4(haploid)\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt.  Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond940:6h\n Cond739: mCLN2:role in cell cycle START,G1 cyclin,Null mutant is viable, ex\nhibits G1 arrest; dominant mutation advances the G(sub)1- to\n S- phase transition and impairs ability of cells to arrest \nin G(sub)1 phase in response to external signals\n Cond531:GAL-PKC1-R398A,3hrs.gallog10(intensity)\n Cond6:anp1\n Cond285:RHO1(tetpromoter)\n mCSI2:chitin synthase involved,chitin synthase 3 complex structura\nl component (putative),Null mutant is viable but shows deloc\nalized chitin deposition\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond588:cdc15_230\n mYPS3:Gpi-anchored aspartic protease (Yapsin 3),GPI-anchored aspar\ntic protease,Null mutant is viable\n Cond709:t0+Vec\n Cond550:clb2-1\n Cond756: Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond506:bni1Dą50nMaF,60minlog10(intensity)\n Cond287:2-deoxy-D-glucose\n Cond717:t2-SSD1\n Cond278:CDC42(tetpromoter)\n Cond197:yar014c\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network.  Science. 2001 May 4;292(5518\n):929-34.\n Cond563:alpha84\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n  Science. 1998 Oct 23;282(5389):699-705.\n Cond359:2.5mM_DTT_090_min_dtt-1\n Cond134:rpl12a\n mMID2:Protein required for mating,,Null mutant is viable, dies whe\nn exposed to mating pheromone\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond403:Nitrogen_Depletion_3_d\n Cond250:ymr031w-a\n Cond284:PMA1(tetpromoter)\n Cond402:Nitrogen_Depletion_2_d\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n Cond738:90\n Cond876:zero2\n Cond776:Alkali_100'\n Cond283:KAR2(tetpromoter)\n Cond743: Cond360:2.5mM_DTT_120_min_dtt-1\n Cond401:Nitrogen_Depletion_1_d\n Cond534:tec1D+50nMaF/wt+50nMaF,30minlog10(intensity)\n Cond984:pho85D_DMSO_24_hrs._vs._F82G_10_mM_1-Na_PP1_24_hrs._\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n mTOS11:Hypothetical ORF,,\n Cond107:ost3\n Cond348:1mM_Menadione_(40_min)_redo\n Cond560:alpha63\n Cond576:cdc15_110\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond559:alpha56\n mSRL1:Suppressor of rad53 lethality,,\n mSRL3:Suppressor of rad53 lethality,,\n Cond521:fus3-K42Dą50nMaF,30minlog10(intensity)\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth.  Nature. 2000 Jul 6;406(6791):90-4.\n Cond665:mec1_plus_gamma_30_min\n Cond551:alpha0\n Cond549:clb2-2\n Cond939:4h\n Cond884:10\n
mSPR3:a sporulation-specific homologue of the yeast CDC3/10/11/12 \nfamily of bud neck microfilament genes; regulated by ABFI,,N\null mutant is viable\n mVPS74:Unknown ,, Unknown\n mSIP1:SNF1 protein kinase substrate,protein kinase complex compone\nnt,Null mutant is viable, exhibits a slight increase in GAL \ngene expression\n mBRE1:Hypothetical ORF,,null mutant is sensitive to brefeldin A\n mYDR326C:Unknown ,, Unknown\n mYHL021C:Unknown ,, Unknown\n mBEM3:Gtpase-activating protein activity toward the essential bud-\nsite assembly GTPase Cdc42,rho GTPase activating protein (GA\nP),Null mutant is viable.\n mBUD7:bud site selection,,Diploid-specific heterogenous bud site s\nelection\n mCLB2:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb1 mutation)\n mSTV1:Stv1p and Vph1p may be equivalent subunits for vacuolar-type\n H(+)-ATPases located on different organelles,110 kDa subuni\nt; not in vacuole membrane , vacuolar H-ATPase,Null mutant i\ns viable, displays additive phenotypes in combination with v\nph1 null mutations\n mYDR179W-A:Unknown ,, Unknown\n mYBR027C:Unknown ,, Unknown\n mMDM1:Intermediate filament protein involved in organelle inherita\nnce,intermediate filament protein,Null mutant is inviable; t\nemperature sensitive mutants display defective transfer of n\nuclei and mitochondria into developing buds at the non-permi\nssive temperature\n mYNL127W:Unknown ,, Unknown\n mDAL81:Positive regulator of multiple nitrogen catabolic genes,tran\nscriptional activator for allantoin and GABA catabolic genes\n, contains a Zn[2]-Cys[6] fungal-type binuclear cluster doma\nin in the N-terminal region,Null mutant is viable, unable to\n degrade allantoin\n mWWM1:Unknown ,, Unknown\n mSCD6:multicopy suppressor of clathrin deficiency,,viable with no \nobvious growth deffect\n mYPL150W:Unknown ,, Unknown\n mYPL013C:Unknown ,, Unknown\n mYFL034W:Unknown ,, Unknown\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mNCR1:Niemann-Pick Type C homologous gene,transmembrane protein (p\nutative),Null mutant is viable.\n mNMD2:Protein involved in decay of mRNA containing nonsense codons\n,,Null mutant is viable, exhibits stabilization of nonsense-\ncontaining mRNAs\n mYPL136W:Unknown ,, Unknown\n mYBL010C:Unknown ,, Unknown\n mAMD1:putative alpha-mannosidase,alpha-mannosidase (putative),Null\n mutant is viable\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mYHR162W:Unknown ,, Unknown\n mHMX1:Unknown ,, Unknown\n mYMR029C:Unknown ,, Unknown\n mGIS2:GIG3 suppressor,,\n mYPL159C:Unknown ,, Unknown\n mDPP1:contains a novel phosphatase sequence motif found in a super\n family of phosphatases including mammalian PAP2,diacylglyce\nrol pyrophosphate phosphatase,Null mutant is viable, does no\nt exhibit any obvious growth defects\n mGCN2:Derepression of GCN4 expression,eukaryotic initiation factor\n 2 alpha (eIF2-alpha) kinase,Null mutant is viable, unable t\no grow on medium containing 3-aminotriazole (3-AT), a compet\nitive inhibitor of histidine biosynthesis, because it cannot\n derepress GCN4 and its target genes in the histidine biosyn\nthetic pathway\n mPEX3:48-kDa peroxisomal integral membrane protein,48 kDa peroxiso\nmal integral membrane protein,Mutant lacks peroxisomes and s\nhows cytosolic mislocalization of peroxisomal matrix enzymes\n mPEX6:Required for peroxisome assembly,AAA ATPase,lack of peroxiso\nme biogenesis\n mYPR038W:Unknown ,, Unknown\n mLHP1:Protein homologous to human La (SS-B) autoantigen,,Null muta\nnt is viable\n mPMP2:May regulate plasma membrane H(+)-ATPase; nearly identical t\no PMP1,proteolipid associated with plasma membrane H(+)-ATPa\nse (Pma1p),Null mutant is viable; pmp1 pmp2 double mutant di\nsplays lower Vmax for the plasma membrane H(+)-ATPase (Pma1p\n)\n mYAL053W:Unknown ,, Unknown\n mPMA2:plasma membrane ATPase,plasma membrane ATPase,Null mutant is\n viable\n mSTP3:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mCOY1:Unknown ,, Unknown\n mYBR071W:Unknown ,, Unknown\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mTIS11:Zinc finger containing homolog of mammalian TIS11, glucose r\nepressible gene,,Null mutant is viable but alters metabolism\n that is reflected by a pH change on YPD plates.\n mNTO1:Unknown ,, Unknown\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mYNL063W:Unknown ,, Unknown\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYNL136W:Unknown ,, Unknown\n mSIZ1:Sap and mIZ. Contains two known protein motifs: SAP (DNA bin\nding) and MIZ-finger,chromatin protein,Null mutant is viable\n.  SIZ1 is a dosage bypass suppressor of an SMT4 deletion. A\n siz1 siz2 deletion has a synthetic phenotype (slow growth).\n mECM17:ExtraCellular Mutant,sulfite reductase (putative),loss of fu\nnction mutants are methionine requiring and sensitive to the\n cell wall perturbing agent calcoflour white.\n mYPR039W:Unknown ,, Unknown\n mYOR322C:Unknown ,, Unknown\n mMAI1:Unknown ,, Unknown\n mYCL005W:Unknown ,, Unknown\n mYBL012C:Unknown ,, Unknown\n mAPL2:Beta-adaptin, large subunit of the clathrin-associated prote\nin (AP-1) complex,beta-adaptin , clathrin associated protein\n complex large subunit,null mutant is viable\n mYMR160W:Unknown ,, Unknown\n mMCK1:Disp. for mitosis, required for chr. segregation, benomyl re\nsist., basal IME1 transcript. in mitosis, IME1 induction in \nmeiosis & ascus mat. independ. of IME1; maybe in mitotic chr\n. segregation specific to CDEIII,43.1 kDa serine/threonine/t\nyrosine protein kinase,Null mutant is viable, cold sensitive\n, temperature sensitive, and benomyl sensitive; associated w\nith delays and decreased levels of sporulation. High copy MC\nK1 acclerates early gene expression.\n mARN2:Siderophore transporter for triacetylfusarinine C,triacetylf\nusarinine C transporter,YHL047c disrupted cells are unable t\no take up and utilize iron from triacetylfusarinine C und fu\nsigen\n mYJL192C:Unknown ,, Unknown\n mYOR053W:Unknown ,, Unknown\n mYKL098W:Unknown ,, Unknown\n mTRS33:Trapp subunit of 33 kDa,,Null mutant is viable\n mYOL036W:Unknown ,, Unknown\n mRGA2:contains a Rho-GAP domain and two LIM domains, similar to Rg\na1p and all known Rho-GAPs,Rho-GTPase Activating Protein,Nul\nl mutants are viable but increase the restrictive temperatur\ne of a cdc24-4 strain and increase the constitutive activati\non of the pheromone response pathway in conjungtion with mut\nations in RGA1 and BEM3; overexpression of RGA2 causes a dec\nrease in the restrictive temperature of a cdc42-1 strain\n mYNL057W:Unknown ,, Unknown\n mYDL050C:Unknown ,, Unknown\n mYCR001W:Unknown ,, Unknown\n mYMR074C:Unknown ,, Unknown\n mYLR400W:Unknown ,, Unknown\n mMDM32:Unknown ,, Unknown\n mINP54:INositol polyphosphate 5-Phosphatase, fourth one identified;\n has homology to Type I mammalian inositol polyphosphate 5-p\nhosphatases,inositol polyphosphate 5-phosphatase,\n mAPM4:Clathrin associated protein, medium subunit,clathrin associa\nted protein complex medium subunit,\n mYMR158W-A:Unknown ,, Unknown\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n mEMP47:47 kDa type I transmembrane protein localized to the Golgi,4\n7 kDa type I transmembrane protein localized to the Golgi,Nu\nll mutant is viable\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mYJR116W:Unknown ,, Unknown\n mSYS1:Multicopy suppressor of ypt6 null mutation,,Null mutant is v\niable. sys1 ypt6 double mutant displays enhanced defects in \nvacuolar sorting and cell growth\n mYIL135C:Unknown ,, Unknown\n mSNF7:Involved in derepression of SUC2 in response to glucose limi\ntation,,Null mutant is viable. Similar to disruption SNF8, S\nNF7 disruption causes a fewfold decrease in invertase derepr\nession, a growth defect on raffinose, temperature-sensitive \ngrowth on glucose, and a sporulation defect in homozygous di\nploids. Genetic interactions suggest SNF7 is different from \nSNF2, SNF5 and SNF6, members of the SNF/SWI chromatin remode\nling complex\n mYDR112W:Unknown ,, Unknown\n mTHR4:threonine synthase,threonine synthase,threonine requiring\n mZRG8:Zinc regulated gene,,\n mYGL235W:Unknown ,, Unknown\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n mANT1:adenine nucleotide transporter,,Null: growth defect on mediu\nm-chain length fatty acids.\n mCNA1:calmodulin binding protein homologous to mammalian calcineur\nin,calcineurin subunit A,Null mutant is viable (no obvious p\nhenotype)\n mMRPS9:Probable mitochondrial ribosomal protein S9,ribosomal protei\nn S9 (putative),Null mutant is viable, respiration deficient\n, exhibits defects in mitochondrial protein synthesis as ind\nicated by a loss of cytochrome c oxidase activity\n mYCL001W-A:Unknown ,, Unknown\n mYCR082W:Unknown ,, Unknown\n mSPP1:YPL138C,,\n mTOM6:involved in supporting the cooperativity between receptors a\nnd the general insertion pore and facilitating the release o\nf preproteins from import components,associates with TOM40 ,\n protein translocation complex component , associates with T\nOM40 , protein translocation complex component,Null mutant i\ns viable, associated with a delay of import of preproteins, \nstabilization of preprotein binding to receptors and the gen\neral insertion pore, and destabilization of the interaction \nbetween receptors and the general insertion pore; tom6 tom40\n double mutants are inviable.\n mCLG1:cyclin-like protein that interacts with Pho85p in affinity c\nhromatography,,Null mutant is viable\n mYPL184C:Unknown ,, Unknown\n mSYT1:Suppressor of Ypt3,,\n mRHO2:Gtp-binding protein of the rho subfamily of ras-like protein\ns,GTP-binding protein , rho subfamily,null is viable\n mYPS7:Gpi-anchored aspartic protease (Yapsin 7),GPI-anchored aspar\ntic protease,\n mYDL073W:Unknown ,, Unknown\n mFUI1:uridine permease,uridine permease,Null mutant is viable, res\nistant to 5-fluorouridine and does not grow on media contain\ning uridine as the sole source of pyrimidines\n mENT5:Unknown ,, Unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYGR268C:Unknown ,, Unknown\n mFIN1:Cell cycle-dependent filament between nuclei,cell cycle-depe\nndent filament between nuclei,Null mutant is viable; overpro\nduction is lethal in haploids and strongly inhibits growth i\nn diploids.\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n mUFD2:Ubiquitin fusion degradation protein,,Null mutant is viable \nbut exhibits increased sensitivity to ethanol stress.\n mDSS4:dominant suppressor of sec4,GDP dissociation factor for Sec4\np,Null mutant is viable\n mIDS2:IME2-Dependent Signalling,,Null mutations reduce or abolish \nthe ability of IME2p to activate expression of early, middle\n, and late meiotic genes. Recessive and null ids2 mutants pr\nevent toxicity of Ime2p expression in rad52 haploids, but do\n not affect Ime2p polypeptide accumulation.\n mCNB1:Type 2B protein phosphatase; regulatory B subunit of calcine\nurin,calcineurin regulatory B subunit , type 2B protein phos\nphatase , calcineurin regulatory B subunit , type 2B protein\n phosphatase,Null mutant is viable, Li+ and Na+ sensitive, c\nnb1 fks1 and cnb1 vma3 double mutants are inviable\n mYOL003C:Unknown ,, Unknown\n mVTC1:Null mutant identified in different genetic screens both by \nits ability to reverse the Cdc42p suppression of a cdc24-4ts\n mutant and its ability to suppress the vacuolar ATPase null\n phenotype,S. pombe Nrf1p homolog (97% identical in predicte\nd amino acid sequence),Null mutant is viable, but exhibits b\noth reduced V-ATPase in the vacuolar membrane and reduced H(\n+)-ATPase(Pma1p) in the plasma membrane\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mRGD2:Unknown ,, Unknown\n mYPR064W:Unknown ,, Unknown\n mAPG12:autophagy,,Null mutant is viable, defective in autophagy\n mKRE1:cell wall beta-glucan assembly,,Null mutant is viable, exhib\nits reduction in cell wall (1--6)-beta-glucan\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mRIF1:RAP1-interacting factor, involved in establishment of repres\nsed chromatin,RAP1-interacting factor,defective in telomeric\n silencing and telomere length regulation\n mAPG16:autophagy,,Null mutant is viable, defective in autophagy\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n mSPT23:Dosage dependent suppressor of Ty-induced promoter mutations\n,,Null mutant is viable, does not have an Spt- phenotype\n mDSE3:Hypothetical ORF,,\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n mYBR062C:Unknown ,, Unknown\n mSNA2:Unknown ,, Unknown\n mMMP1:S-MethylMethionine Permease,high affinity S-methylmethionine\n permease,Null mutant is viable but is unable to use S-methy\nlmethionine as a sulfur source\n mRER1:Protein involved in retention of membrane proteins, includin\ng Sec12p, in the ER; localized to Golgi, where it may functi\non in returning membrane proteins to the ER,,Null mutant is \nviable and shows mislocalization of transmembrane proteins t\nhat are normally retained in the early secretory compartment\ns\n mYLR454W:Unknown ,, Unknown\n mPTP2:protein tyrosine phosphatase,tyrosine phosphatase,Null mutan\nt is viable, grows slowly, is hypersensitive to heat; ptp2 p\ntc1 mutants exhibit synthetic lethality\n mRAD23:ubiquitin-like protein,ubiquitin-like protein,radiation sens\nitive\n mSKY1:SRPK1-like Kinase in Yeast (SRPK1 is a human serine kinase t\nhat specifically phosphoryates arginine-serine rich domains \nfound in the SR family of splicing factors.),,Slow growth; D\necreased in vivo phosphorylation of npl3p\n mAPG12 mAPG16 mYCR001W mRAD23 mUFD2 mCNB1 mCNA1
Cond664:mec1_plus_gamma_20_min\n Cond547:cln3-1\n Cond663:mec1_plus_gamma_10_min\n Cond397:Nitrogen_Depletion_2_h\n Cond368:dtt_480_min_dtt-2\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYJL083W:Unknown ,, Unknown\n Cond978:pho85D_1_mM_1NaPP1_\n Cond565:alpha98\n Cond548:cln3-2\n Cond578:cdc15_130\n mASH1:Zinc-finger inhibitor of HO transcription which is asymmetri\ncally localized to the daughter cell nucleus,,Mutant ash1 da\nughters can transcribe HO and switch mating type\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond552:alpha7\n Cond654:wt_plus_gamma_45_min\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond585:cdc15_200\n Cond941:SK1_YPD\n Cond740: Cond735: Cond657:wt_plus_gamma_120_min\n Cond579:cdc15_140\n Cond556:alpha35\n Cond561:alpha70\n Cond99:med2(haploid)\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond573:cdc15_80\n Cond586:cdc15_210\n Cond943:SK1_YPA\n Cond808:Na15'\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mHSP150:Heat shock protein, secretory glycoprotein,heat shock protei\nn , secretory glycoprotein , heat shock protein , secretory \nglycoprotein , heat shock protein , secretory glycoprotein,N\null mutant is viable\n Cond562:alpha77\n Cond748: COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles.  Science. 200\n0 Feb 4;287(5454):873-80\n Cond231:yhr031c\n Cond531:GAL-PKC1-R398A,3hrs.gallog10(intensity)\n Cond753: Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond934:8h\n Cond566:alpha105\n Cond961:t7_g/r_ratio\n Cond752: Cond508:bni1Dą50nMaF,120minlog10(intensity)\n Cond61:fks1(haploid)\n Cond749: Cond569:cdc15_10\n Cond557:alpha42\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond580:cdc15_150\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast.  Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond794:Intertic\n Cond936:12h\n Cond589:cdc15_240\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond63:fre6\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond563:alpha84\n Cond558:alpha49\n Cond572:cdc15_70\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n  Science. 1998 Oct 23;282(5389):699-705.\n Cond963:t11.5_g/r_ratio\n Cond875:60min\n Cond134:rpl12a\n Cond734: Cond666:mec1_plus_gamma_45_min\n Cond62:fpr1\n Cond799:Ca60'\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond819:crz1/Na45'_\n Cond582:cdc15_170\n Cond205:yel033w\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond959:t2_g/r_ratio\n Cond571:cdc15_50\n Cond575:cdc15_100\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond574:cdc15_90\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond583:cdc15_180\n Cond747: Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond560:alpha63\n Cond555:alpha28\n Cond960:t5_g/r_ratio\n Cond570:cdc15_30\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast.  Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond584:cdc15_190\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mMSU1:Protein essential for mitochondrial biogenesis,3'-5' exonucl\nease complex component,\n Cond938:2h\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond962:t9_g/r_ratio\n Cond577:cdc15_120\n mMSY1:Tyrosyl-tRNA synthetase,tyrosine-tRNA ligase,\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth.  Nature. 2000 Jul 6;406(6791):90-4.\n mPIR1:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) do\nuble mutant and pir1 hsp150 (pir2) pir3 triple mutant are sl\now-growing on agar slab and sensitive to heat shock\n Cond665:mec1_plus_gamma_30_min\n Cond549:clb2-2\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n

this is an automaticly generated GENESYS report
Computational Genomics Lab, Tel-Aviv uniresity