Module autophagy




Database revision : gnsdb28.10
Date : Fri Feb 28 01:36:31 2003
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mYNL319W:Unknown ,, Unknown\n mRAD28:Protein involved in the same pathway as Rad26p, has beta-tra\nnsducin (WD-40) repeats,,Null mutant is viable but is hyperm\nutable following exposure to UV light and is slightly more s\nensitive to UV light in the presence of mutations in rad7 or\n rad16\n mAPG5:Involved in autophagy,,reduced viability upon nutrient starv\nation; defective in autophagy\n mVPS74:Unknown ,, Unknown\n mAPG7:autophagy,,Null mutant is viable, defective in autophagy\n mGLT1:Glutamate synthase (NADH),glutamate synthase (NADH),Null mut\nant is viable\n mENT5:Unknown ,, Unknown\n mUGA3:Transcriptional activator necessary for gamma-aminobutyrate \n(GABA)-dependent induction of GABA genes (such as UGA1, UGA2\n, UGA4),zinc finger transcription factor of the Zn(2)-Cys(6)\n binuclear cluster domain type,Null mutant is viable but exh\nibits defects in activation of UGA1 and UGA4.\n mYMR258C:Unknown ,, Unknown\n mYDR031W:Unknown ,, Unknown\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mSFH5:Unknown ,, Unknown\n mHNT3:Unknown ,, Unknown\n mCLB3:Involved in mitotic induction and perhaps in DNA replication\n and spindle assembly,B-type cyclin,Null mutant is viable\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n mYBR027C:Unknown ,, Unknown\n mPES4:Suppressor of DNA polymerase epsilon mutation,poly(A) bindin\ng protein , similar to YHR015W,\n mYBR216C:Unknown ,, Unknown\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYMR126C:Unknown ,, Unknown\n mYJR054W:Unknown ,, Unknown\n mVPS27:hydrophilic protein; has cysteine rich putative zinc finger \nesential for function,cysteine rich putative zinc finger ess\nential for function , hydrophilic protein , cysteine rich pu\ntative zinc finger essential for function , hydrophilic prot\nein , cysteine rich putative zinc finger essential for funct\nion , hydrophilic protein , cysteine rich putative zinc fing\ner essential for function , hydrophilic protein , cysteine r\nich putative zinc finger essential for function , hydrophili\nc protein , cysteine rich putative zinc finger essential for\n function , hydrophilic protein,required for membrane traffi\nc to the vacuole\n mVPS29:vacuolar protein sorting,,Defective for sorting of soluble h\nydrolases to the vacuole. Mislocalisation of the vacuolar hy\ndrolase sorting receptor Vps10p.\n mITC1:Imitation switch Two Complex 1,,Null mutant is viable, but s\nhows abnormal morphology and reduced mating efficiency when \nthe disruption is in a MATalpha background. \n mYPR197C:Unknown ,, Unknown\n mYNL100W:Unknown ,, Unknown\n mEAF6:Unknown ,, Unknown\n mYJL207C:Unknown ,, Unknown\n mAUT1:Protein involved in autophagocytosis during starvation,,Null\n mutant is viable, defective in starvation-induced bulk flow\n transport of cytoplasmic proteins to the vacuole, exhibits \ndecreased survival rates during starvation, defective in pro\ntein degradation in the vacuoles induced by nitrogen starvat\nion, homozygous diploids fail to sporulate\n mAPG12:autophagy,,Null mutant is viable, defective in autophagy\n mYBL012C:Unknown ,, Unknown\n mAPG13:autophagy,,Defective in autophagy\n mPHO13:p-nitrophenyl phosphatase,p-nitrophenyl phosphatase,Null mut\nant is viable\n mAPG16:autophagy,,Null mutant is viable, defective in autophagy\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mSTB6:binds Sin3p in two-hybrid assay,,Null mutant is viable\n mIDP3:peroxisomal NADP-dependent isocitrate dehydrogenase,NADP-dep\nendent isocitrate dehydrogenase,Null mutant is viable but is\n unable to grow on polyunsaturated fatty acids as sole carbo\nn source\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mNFU1:Nifu-like protein,,Null mutant is viable on YPD 30 degrees C\n, and is synthetically lethal with SSQ1\n mYOR296W:Unknown ,, Unknown\n mELA1:similar to mammalian elongin A, interacts with elongin C,elo\nngin A transcription elongation factor,viable\n mSNA2:Unknown ,, Unknown\n mYER140W:Unknown ,, Unknown\n mCCC1:Functions in the homeostasis of both calcium and manganese i\nons,transmembrane Ca2+ transporter (putative),Wild-type comp\nlements csg1 (calcium sensitive-group) mutants when overexpr\nessed\n mARP1:actin-related protein of the dynactin complex,,Null mutant i\ns viable, but both null mutations and overexpression lead to\n defects in spindle orientation and nuclear migration\n mTRS33:Trapp subunit of 33 kDa,,Null mutant is viable\n mGIS2:GIG3 suppressor,,\n mYDL050C:Unknown ,, Unknown\n mAUT7 mAPG7 mAUT1 mAPG12 mFET3 mAPG16 mAPG5
mYGR273C:Unknown ,, Unknown\n mBNI4:bud neck involved,required to link Chs3p and Chs4p to the se\nptins,Null mutant is viable, shows delocalized chitin, elong\nated buds, enlarged bud necks\n mYFR026C:Unknown ,, Unknown\n mHMS2:High-copy mep2 suppressor,heat shock transcription factor ho\nmolog,Null mutant is viable; multicopy expression suppresses\n the pseudohyphal defect of mep2/mep2 strains\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mURA4:Third step in pyrimidine biosynthesis pathway,dihydrooratase\n,Null mutant is viable and requires uracil\n mYJL171C:Unknown ,, Unknown\n mYMR158W-A:Unknown ,, Unknown\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mYHL021C:Unknown ,, Unknown\n mSLY41:multicopy suppressor of ypt1 deletion,chloroplast phosphate \ntransporter homolog,Null mutant is viable\n mBEM3:Gtpase-activating protein activity toward the essential bud-\nsite assembly GTPase Cdc42,rho GTPase activating protein (GA\nP),Null mutant is viable.\n mBUD7:bud site selection,,Diploid-specific heterogenous bud site s\nelection\n mCRZ1:calcineurin responsive zinc-finger,transcription factor (put\native),Null mutant is viable\n mYDR179W-A:Unknown ,, Unknown\n mPDR8:Unknown ,, Unknown\n mDDP1:Diadenosine and Diphosphoinositol Polyphosphate Phosphohydro\nlase,diadenosine and diphosphoinositol polyphosphate phospho\nhydrolase,none\n mWWM1:Unknown ,, Unknown\n mYIL152W:Unknown ,, Unknown\n mYJL051W:Unknown ,, Unknown\n mYOL160W:Unknown ,, Unknown\n mYJR098C:Unknown ,, Unknown\n mYPL150W:Unknown ,, Unknown\n mMNR2:Product of gene unknown,,overexpression overcomes manganese \ntoxicity\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mYPL216W:Unknown ,, Unknown\n mYPL136W:Unknown ,, Unknown\n mJNM1:coiled-coil domain protein required for proper nuclear migra\ntion during mitosis (but not during conjugation),,Null mutan\nt is viable but is cold-sensitive\n mSEY1:Unknown ,, Unknown\n mDAN1:Delayed Anaerobic,cell wall mannoprotein , induced during an\naerobic growth,Null mutant is viable\n mYOR164C:Unknown ,, Unknown\n mYUH1:ubiquitin hydrolase,ubiquitin hydrolase,\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mZRG8:Zinc regulated gene,,\n mYHR130C:Unknown ,, Unknown\n mDPL1:dihydrosphingosine phosphate lyase (also known as sphingosin\ne phosphate lyase),dihydrosphingosine phosphate lyase (also \nknown as sphingosine phosphate lyase),Null mutant is viable \nbut is sensitive to exogenous D- erythro-sphingosine and phy\ntosphingosine and accumulates sphingosine 1-phosphate upon e\nxposure to exogenous sphingosine; overexpression confers res\nistance to sphingosine\n mHMX1:Unknown ,, Unknown\n mRDS2:Unknown ,, Unknown\n mRMD5:Unknown ,, Unknown\n mSPP1:YPL138C,,\n mYBR100W:Unknown ,, Unknown\n mSAG1:alpha-agglutinin,alpha-agglutinin,Null mutant is viable and \nshows loss of cellular agglutination in alpha cells\n mCLG1:cyclin-like protein that interacts with Pho85p in affinity c\nhromatography,,Null mutant is viable\n mIES5:Ino Eighty Subunit 5,,Null: non essential.\n mYMR306C-A:Unknown ,, Unknown\n mYPL184C:Unknown ,, Unknown\n mGIS2:GIG3 suppressor,,\n mTEA1:Mutants are defective in Ty1 Enhancer-mediated Activation,,D\niminished Ty1 expression\n mYNR062C:Unknown ,, Unknown\n mYDR411C:Unknown ,, Unknown\n mAPG5:Involved in autophagy,,reduced viability upon nutrient starv\nation; defective in autophagy\n mYHR132W-A:Unknown ,, Unknown\n mENT1:epsin N-terminal homology-containing protein,,Null mutant is\n viable, synthetically lethal with ent2 (YLR206w). ent1/2 do\nuble mutants have endocytosis and actin cytoskeleton defects\n.\n mAPG7:autophagy,,Null mutant is viable, defective in autophagy\n mFUI1:uridine permease,uridine permease,Null mutant is viable, res\nistant to 5-fluorouridine and does not grow on media contain\ning uridine as the sole source of pyrimidines\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mENT5:Unknown ,, Unknown\n mHBS1:Protein related to translation elongation factor EF-1alpha a\nnd to Suf12p/Sup2p/Gst1p/Sup35p,,\n mDIN7:DNA-damage inducible gene,,\n mOM45:45-kDa mitochondrial outer membrane protein,45 kDa mitochond\nrial outer membrane protein,Null mutant is viable and shows \nnormal growth, viability, mitochondrial function and mitocho\nndrial protein import\n mYBR071W:Unknown ,, Unknown\n mYIL121W:Unknown ,, Unknown\n mYML117W:Unknown ,, Unknown\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mTIS11:Zinc finger containing homolog of mammalian TIS11, glucose r\nepressible gene,,Null mutant is viable but alters metabolism\n that is reflected by a pH change on YPD plates.\n mNTO1:Unknown ,, Unknown\n mTRM82:Unknown ,, Unknown\n mCOS10:Protein with strong similarity to subtelomerically-encoded p\nroteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, \nCos6p, Cos9p,,\n mILV1:threonine deaminase,threonine deaminase,Isoleucine-plus-vali\nne requiring\n mBOP2:bypass of PAM1,,\n mYLR152C:Unknown ,, Unknown\n mYNL089C:Unknown ,, Unknown\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYRR1:Yeast Reveromycin-A Resistant,transcription factor,Null muta\nnt is viable, hypersensitive to 4-nitroquinoline oxide (4-NQ\nO); the YRR1-1 allele confers resistance to 4-NQO, reveromyc\nin-A and oligomycin\n mYPL004C:Unknown ,, Unknown\n mGRX1:Glutaredoxin,glutaredoxin,Null mutant is viable but sensitiv\ne to oxidative stress. grx1 grx2 null mutants are viable but\n lack heat-stable oxidoreductase activity.\n mAUA1:Involved in ammonia regulation of GAP1 activity,,Null mutant\n is viable\n mITC1:Imitation switch Two Complex 1,,Null mutant is viable, but s\nhows abnormal morphology and reduced mating efficiency when \nthe disruption is in a MATalpha background. \n mYPR039W:Unknown ,, Unknown\n mMAI1:Unknown ,, Unknown\n mYIL137C:Unknown ,, Unknown\n mAPL1:beta-adaptin, large subunit of the clathrin-associated prote\nin complex,beta-adaptin , clathrin associated protein comple\nx large subunit,null mutant is viable\n mAUT1:Protein involved in autophagocytosis during starvation,,Null\n mutant is viable, defective in starvation-induced bulk flow\n transport of cytoplasmic proteins to the vacuole, exhibits \ndecreased survival rates during starvation, defective in pro\ntein degradation in the vacuoles induced by nitrogen starvat\nion, homozygous diploids fail to sporulate\n mAPG12:autophagy,,Null mutant is viable, defective in autophagy\n mAPG13:autophagy,,Defective in autophagy\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mAPL4:Gamma-adaptin, large subunit of the clathrin-associated prot\nein (AP) complex,clathrin associated protein complex large s\nubunit , gamma-adaptin,\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mAPG16:autophagy,,Null mutant is viable, defective in autophagy\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mYGL226W:Unknown ,, Unknown\n mDSE3:Hypothetical ORF,,\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mHOT1:high osmolarity induced transcription,nuclear protein,osmost\nress hypersensitivity\n mHXT12:High-affinity hexose transporter,hexose permease,\n mYCL063W:Unknown ,, Unknown\n mYJL192C:Unknown ,, Unknown\n mPAK1:high copy suppressor of temperature sensitive cdc17 (DNA pol\nymerase alpha) mutations,,Null mutant is viable\n mELA1:similar to mammalian elongin A, interacts with elongin C,elo\nngin A transcription elongation factor,viable\n mSNA2:Unknown ,, Unknown\n mMMP1:S-MethylMethionine Permease,high affinity S-methylmethionine\n permease,Null mutant is viable but is unable to use S-methy\nlmethionine as a sulfur source\n mYAL004W:Unknown ,, Unknown\n mKAP114:KAryoPherin (collective name for homologous family of nuclea\nr transport receptors) of approximately 114kD,,The null muta\nnt is viable.\n mRER1:Protein involved in retention of membrane proteins, includin\ng Sec12p, in the ER; localized to Golgi, where it may functi\non in returning membrane proteins to the ER,,Null mutant is \nviable and shows mislocalization of transmembrane proteins t\nhat are normally retained in the early secretory compartment\ns\n mYDR474C:Unknown ,, Unknown\n mYJL200C:Unknown ,, Unknown\n mYDL050C:Unknown ,, Unknown\n

this is an automaticly generated GENESYS report
Computational Genomics Lab, Tel-Aviv uniresity