| ID | Symbol | Description | Aliases | Front Node |
| YNL307C | MCK1 | Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family | YPK1 | F |
| YBR248C | HIS7 | Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor | | T |
| YAR042W | SWH1 | Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction | OSH1, YAR044W | T |
| YFL045C | SEC53 | Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen | ALG4 | T |
| YFR034C | PHO4 | Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability | | T |
| YPR058W | YMC1 | Putative mitochondrial inner membrane transporter, member of the mitochondrial carrier (MCF) family | | T |
| YMR277W | FCP1 | Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) | | T |
| YNL244C | SUI1 | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase | MOF2, RFR1, eIF-1, eIF1 | T |
| YER040W | GLN3 | Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source | | F |
| YIL016W | SNL1 | Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein | | T |
| YNL062C | GCD10 | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression | TRM6 | T |
| YDL055C | PSA1 | GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure | MPG1, SRB1, VIG9 | F |
| YIL148W | RPL40A | Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes | CEP52A, UB11, UBI1 | T |
| YDL019C | OSH2 | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability | | T |
| YNL129W | NRK1 | Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis | | T |
| YHR036W | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a cold-sensitive mutant of CRM1, a karyopherin; homologous to and interacts with Brr6p, which is a nuclear envelope protein involved in nuclear export | | T |
| YMR120C | ADE17 | Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine | | T |
| YLR207W | HRD3 | Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events | | F |
| YPL266W | DIM1 | Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing | CDH1 | T |
| YIR018W | YAP5 | Basic leucine zipper (bZIP) transcription factor | | T |
| YJR070C | LIA1 | Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning | MMD1 | T |
| YBR061C | TRM7 | 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop | | T |
| YHR175W | CTR2 | Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation | | T |
| YJL011C | RPC17 | RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex | C17 | T |
| YAL034W-A | MTW1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly | DSN3, NSL2 | T |
| YML025C | YML6 | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins | | F |
| YHR059W | FYV4 | Protein of unknown function, required for survival upon exposure to K1 killer toxin | | T |
| YJL177W | RPL17B | Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins | | T |
| YIL074C | SER33 | 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p | | T |
| YAL067C | SEO1 | Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide | | T |
| YPR018W | RLF2 | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-I) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin | CAC1 | T |
| YDL137W | ARF2 | ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p | | T |
| YOR212W | STE4 | G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats | HMD2 | T |
| YMR193W | MRPL24 | Mitochondrial ribosomal protein of the large subunit | MRPL14, YmL14, YmL24 | T |
| YMR146C | TIF34 | Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation | | T |
| YNL027W | CRZ1 | Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation | HAL8, TCN1 | F |
| YPL090C | RPS6A | Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein | | T |
| YIL061C | SNP1 | Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein | U1 70K, U1-70K | F |
| YOR201C | MRM1 | Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA | PET56 | T |
| YKR095W | MLP1 | Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs | MPL1 | F |
| YKL143W | LTV1 | Protein required for growth at low temperature | YKL2 | T |
| YOR096W | RPS7A | Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins | RPS30 | T |
| YNL185C | MRPL19 | Mitochondrial ribosomal protein of the large subunit | YmL19 | T |
| YJL129C | TRK1 | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter | | T |
| YLR229C | CDC42 | Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins | | T |
| YNR030W | ALG12 | Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation | ECM39 | F |
| YER052C | HOM3 | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | BOR1, SIL4 | T |
| YJL125C | GCD14 | Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression | TRM61 | T |
| YGR173W | RBG2 | Protein with similarity to mammalian developmentally regulated GTP-binding protein | GIR1 | T |
| YKL110C | KTI12 | Protein associated with the RNA polymerase II Elongator complex; involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin, zymocin | TOT4 | T |
| YHR077C | NMD2 | Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance | IFS1, SUA1, UPF2 | T |
| YMR143W | RPS16A | Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins | | T |
| YBR157C | ICS2 | Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | | T |
| YPL239W | YAR1 | Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock | | T |
| YER118C | SHO1 | Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway | SSU81 | T |
| YPL227C | ALG5 | UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum | | T |
| YLR205C | HMX1 | ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 | | T |
| YHR148W | IMP3 | Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA | | T |
| YLR142W | PUT1 | Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source | | T |
| YPR062W | FCY1 | Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) | yCD | T |
| YER091C | MET6 | Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs | | T |
| YLR264W | RPS28B | Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein | RPS33B | T |
| YDR068W | DOS2 | Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | | T |
| YPL263C | KEL3 | Cytoplasmic protein of unknown function | | T |
| YKL120W | OAC1 | Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family | | T |
| YLR183C | TOS4 | Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF | | T |
| YIL149C | MLP2 | Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length | | T |
| YGR148C | RPL24B | Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate | RPL30B | T |
| YIL070C | MAM33 | Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R | | T |
| YGL232W | TAN1 | Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA | | T |
| YMR096W | SNZ1 | Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins | | T |
| YDL155W | CLB3 | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation | | F |
| YAL038W | CDC19 | Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration | PYK1 | T |
| YOR232W | MGE1 | Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE | GRPE, YGE1 | T |
| YLR192C | HCR1 | Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA | | T |
| YNL199C | GCR2 | Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p | | F |
| YKL122C | SRP21 | Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm | | T |
| YDR432W | NPL3 | RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; phosphorylation by Sky1p in the cytoplasm may promote release of mRNAs | MTR13, MTS1, NAB1, NOP3 | T |
| YGL200C | EMP24 | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport | BST2 | T |
| YDR398W | UTP5 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | | T |
| YDR354W | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis | | T |
| YNL281W | HCH1 | Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus | | T |
| YMR239C | RNT1 | RNAase III; cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end | | T |
| YLR214W | FRE1 | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels | | T |
| YLR401C | DUS3 | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region | | T |
| YOR027W | STI1 | Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein | | T |
| YGL184C | STR3 | Cystathionine beta-lyase, converts cystathionine into homocysteine | | T |
| YGL071W | RCS1 | Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability | AFT1 | T |
| YNL162W | RPL42A | Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein | | T |
| YNL272C | SEC2 | Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport | | T |
| YBL072C | RPS8A | Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein | | T |
| YOL069W | NUF2 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering | | T |
| YKL049C | CSE4 | Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A | CSL2 | T |
| YKL214C | YRA2 | Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus | | T |
| YDL067C | COX9 | Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain | | T |
| YIL147C | SLN1 | Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators | YPD2 | T |
| YER090W | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p | | T |
| YNR022C | MRPL50 | Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation | | T |
| YDR281C | PHM6 | Protein of unknown function, expression is regulated by phosphate levels | | T |
| YLL062C | MHT1 | S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio | | T |
| YML080W | DUS1 | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 | | T |
| YKL001C | MET14 | Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism | | T |
| YPR035W | GLN1 | Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation | | T |
| YLR180W | SAM1 | S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) | ETH10 | T |
| YPR187W | RPO26 | RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit | ABC23, RPB6 | T |
| YNL177C | MRPL22 | Mitochondrial ribosomal protein of the large subunit | | T |
| YPR173C | VPS4 | AAA-type ATPase required for efficient late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; cytoplasmic protein that is also associated with an endosomal compartment | CSC1, DID6, END13, GRD13, VPL4, VPT10 | T |
| YMR260C | TIF11 | Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 | eIF1A | T |
| YBR034C | HMT1 | Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants | HCP1, ODP1, RMT1 | T |
| YDL084W | SUB2 | Component of the TREX complex required for nuclear mRNA export; DEAD-box RNA helicase involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 | | F |
| YGL255W | ZRT1 | High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor | | T |
| YDL092W | SRP14 | Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 | | T |
| YOL080C | REX4 | Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly | | T |
| YJR132W | NMD5 | Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog | KAP119 | F |
| YHR024C | MAS2 | Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins | MIF2 | T |
| YBR268W | MRPL37 | Mitochondrial ribosomal protein of the large subunit | YmL37 | T |
| YDR429C | TIF35 | Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation | | T |
| YDR152W | GIR2 | Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein) | | T |
| YNL087W | TCB2 | Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud via the mRNA transport system involving She2p | | T |
| YLR190W | MMR1 | Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p | | T |