| ID | Symbol | Description | Aliases | Front Node |
| YOR187W | TUF1 | Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans | | T |
| YLR249W | YEF3 | Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP | EF-3, TEF3 | T |
| YJL044C | GYP6 | GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport | | F |
| YHR186C | KOG1 | Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors | LAS24 | T |
| YOR264W | DSE3 | Daughter cell-specific protein, may help establish daughter fate | | F |
| YER120W | SCS2 | Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog | | T |
| YGR192C | TDH3 | Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall | GLD1, HSP35, HSP36, SSS2 | T |
| YGR279C | SCW4 | Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating | | T |
| YPR052C | NHP6A | High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters | | F |
| YGR090W | UTP22 | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data | | F |
| YDR264C | AKR1 | Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats | | F |
| YBR265W | TSC10 | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family | | T |
| YAL030W | SNC1 | Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins | | T |
| YER145C | FTR1 | High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron | | T |
| YNL078W | NIS1 | Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network | JIP1 | T |
| YJL065C | DLS1 | Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing | | T |
| YGL207W | SPT16 | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure | CDC68, SSF1 | F |
| YDR233C | RTN1 | Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily | | T |
| YNL310C | ZIM17 | Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix | FMP28, HEP1, TIM15 | T |
| YPL281C | ERR2 | Protein of unknown function, has similarity to enolases | | T |
| YBL032W | HEK2 | RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length | KHD1 | F |
| YML105C | SEC65 | Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 | | T |
| YAL014C | SYN8 | Endosomal SNARE related to mammalian syntaxin 8 | SLT2, UIP2 | T |
| YKR090W | PXL1 | LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin | | F |
| YAL013W | DEP1 | Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation | FUN54 | T |
| YGR061C | ADE6 | Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway | | T |
| YFL013C | IES1 | Subunit of the INO80 chromatin remodeling complex | | F |
| YDR397C | NCB2 | Beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) | YDR1 | T |
| YER036C | ARB1 | ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p | | F |
| YNL030W | HHF2 | One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity | | T |
| YGR167W | CLC1 | Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component | SCD4 | T |
| YIL030C | SSM4 | Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation | DOA10 | T |
| YDL141W | BPL1 | Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation | ACC2 | T |
| YOL059W | GPD2 | NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria | GPD3 | T |
| YLR150W | STM1 | Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations | MPT4 | T |
| YOR361C | PRT1 | Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes | CDC63, DNA26 | T |
| YLR197W | SIK1 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects | NOP56 | F |
| YKR007W | MEH1 | Component of the EGO complex, which is involved in the regulation of microautophagy; localizes to the vacuolar membrane, loss results in a defect in vacuolar acidification | EGO1 | T |
| YGR163W | GTR2 | Cytoplasmic GTP binding protein, negative regulator of the Ran/Tc4 GTPase cycle downstream of Gtr1p; homolog of human RagC and RagD proteins; component of the EGO complex, which is involved in the regulation of microautophagy | | T |
| YLR221C | RSA3 | Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus | | T |
| YPL082C | MOT1 | Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity | BTAF1, BUR3, LPF4 | F |
| YML102W | CAC2 | Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans | | T |
| YPL001W | HAT1 | Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair | | F |
| YGL213C | SKI8 | Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses | REC103 | F |
| YEL023C | YEL023C | Hypothetical protein | | F |
| YDR098C | GRX3 | Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage | | T |
| YGL026C | TRP5 | Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis | | T |
| YCL009C | ILV6 | Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria | | T |
| YIL022W | TIM44 | Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane | ISP45, MIM44, MPI1 | T |
| YGL078C | DBP3 | Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis | | T |
| YGL150C | INO80 | ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases | | T |
| YJL096W | MRPL49 | Mitochondrial ribosomal protein of the large subunit | YmL49 | T |
| YLR085C | ARP6 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes | | T |
| YGL162W | SUT1 | Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression | | T |
| YIL034C | CAP2 | Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches | | T |
| YAR071W | PHO11 | One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 | | T |
| YPL104W | MSD1 | Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene | LPG5 | T |
| YOL104C | NDJ1 | Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes | TAM1 | T |
| YBR093C | PHO5 | Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 | | T |
| YEL037C | RAD23 | Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins | | T |
| YKL191W | DPH2 | Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p | | T |
| YGL106W | MLC1 | Essential light chain for myosin Myo2p; may stabilize Myo2p by binding to the neck region; may interact with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition | | T |
| YDL140C | RPO21 | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime | B220, RPB1, RPB220, SUA8 | T |
| YHR067W | HTD2 | Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology | RMD12 | T |
| YGR087C | PDC6 | Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, involved in amino acid catabolism | | T |
| YOR091W | TMA46 | Hypothetical protein | RBF46 | T |
| YOR329C | SCD5 | Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1 | FTB1 | T |
| YOL027C | MDM38 | Mitochondrial inner membrane protein, required for K+/H+ exchange and for normal mitochondrial morphology and inheritance; human ortholog Letm1 is implicated in Wolf-Hirschhorn syndrome | MKH1 | T |
| YDL131W | LYS21 | Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p | | T |
| YHR134W | WSS1 | Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks | | T |
| YOL004W | SIN3 | DNA binding subunit of Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression of meiosis-specific genes during vegetative growth and silencing; involved in telomere maintenance | CPE1, GAM2, RPD1, SDI1, SDS16, UME4 | T |
| YLR199C | YLR199C | Hypothetical protein | | F |
| YDR013W | PSF1 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery | CDC101 | T |
| YNR015W | SMM1 | Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs | DUS2 | T |
| YDL039C | PRM7 | Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements | | T |
| YBR059C | AKL1 | Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization | | T |
| YDR454C | GUK1 | Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins | PUR5 | T |
| YER042W | MXR1 | Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan | MSRA | T |
| YAL062W | GDH3 | NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources | FUN51 | T |
| YER019C-A | SBH2 | Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p | SEB2 | T |
| YKL212W | SAC1 | Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion | RSD1 | F |
| YIL051C | MMF1 | Mitochondrial protein involved in maintenance of the mitochondrial genome | IBM1 | T |
| YBR231C | SWC5 | Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin | AOR1 | T |
| YMR216C | SKY1 | SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 | | F |
| YMR296C | LCB1 | Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine | END8, TSC2 | T |
| YNL201C | PSY2 | Nuclear protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin, but not mitomycin C; deletion is synthetically lethal with a chitin synthase (CHS1) null mutant | | F |
| YKL038W | RGT1 | Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor | | F |
| YOL088C | MPD2 | Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p | | T |
| YNL309W | STB1 | Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated | | T |
| YDL182W | LYS20 | Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p | | T |
| YBL069W | AST1 | Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts | | T |
| YFL039C | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions | ABY1, END7, actin | T |
| YER153C | PET122 | Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane | | T |
| YEL026W | SNU13 | RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein | | T |
| YKR048C | NAP1 | Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus | | T |
| YLR043C | TRX1 | Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance | LMA1 | F |
| YDR510W | SMT3 | Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics | | T |
| YBR087W | RFC5 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | | T |
| YDR299W | BFR2 | Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A | | T |
| YLR398C | SKI2 | Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses | | F |
| YPL150W | YPL150W | Hypothetical protein | | F |
| YHR082C | KSP1 | Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation | | F |
| YEL034W | HYP2 | Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; undergoes an essential hypusination modification; expressed under aerobic conditions | TIF51A | T |
| YJR010C-A | SPC1 | Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex | | F |
| YDR283C | GCN2 | Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex | AAS1 | F |
| YJR045C | SSC1 | Mitochondrial matrix ATPase that is a subunit of the presequence translocase-associated protein import motor (PAM); involved in protein translocation into the matrix and protein folding; member of the heat shock protein 70 (HSP70) family | ENS1, mtHSP70 | T |
| YPR175W | DPB2 | Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate | | F |
| YOR359W | VTS1 | Protein of unknown function, shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic | | T |
| YNL277W | MET2 | L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway | | T |
| YOL144W | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis | | T |
| YBL036C | YBL036C | Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity | | F |
| YBR233W | PBP2 | RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length | HEK1 | T |
| YMR186W | HSC82 | Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels that HSP82 and induced 2-3 fold by heat shock | | F |
| YPR034W | ARP7 | Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex | SWP61 | T |