| ID | Symbol | Description | Aliases | Front Node |
| YCR060W | TAH1 | HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs | | T |
| YDR296W | MHR1 | Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning | XTC1 | T |
| YOR388C | FDH1 | NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate | | T |
| YNR067C | DSE4 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother | ENG1 | T |
| YPL256C | CLN2 | G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) | | T |
| YLR055C | SPT8 | Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters | | T |
| YNL016W | PUB1 | Poly(A)+ RNA-binding protein, abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs; not reported to associate with polyribosomes | RNP1 | F |
| YBR167C | POP7 | Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends | RPP2 | T |
| YGR275W | RTT102 | Regulator of Ty1 Transposition; regulator of Ty1 transposition | | T |
| YGR078C | PAC10 | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding | GIM2, PFD3, RKS2 | T |
| YLR189C | ATG26 | UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy | UGT51 | T |
| YOR198C | BFR1 | Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity | | T |
| YER072W | VTC1 | Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase | NRF1, PHM4 | T |
| YDR188W | CCT6 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif | HTR3, TCP20, TCP6 | T |
| YGR191W | HIP1 | High-affinity histidine permease, also involved in the transport of manganese ions | | T |
| YKL072W | STB6 | Protein that binds Sin3p in a two-hybrid assay | | T |
| YFR037C | RSC8 | One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters | SWH3 | T |
| YBL018C | POP8 | Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends | | T |
| YGR076C | MRPL25 | Mitochondrial ribosomal protein of the large subunit | YMR26, YmL25 | T |
| YIL009W | FAA3 | Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery | | T |
| YPL217C | BMS1 | Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p | | T |
| YGR162W | TIF4631 | Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p | | T |
| YHL015W | RPS20 | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins | URP2 | T |
| YDL231C | BRE4 | Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport | | T |
| YDR097C | MSH6 | Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p | PMS3 | T |
| YIL008W | URM1 | Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature | | T |
| YNL232W | CSL4 | Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation | SKI4 | T |
| YCR052W | RSC6 | One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p | | T |
| YHR216W | IMD2 | Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation | PUR5 | T |
| YPL081W | RPS9A | Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins | | T |
| YPR120C | CLB5 | B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase | | T |
| YMR043W | MCM1 | Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes | FUN80 | T |
| YNL221C | POP1 | Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P | | T |
| YJR014W | TMA22 | Hypothetical protein | RBF22 | T |
| YDL208W | NHP2 | Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing | | T |
| YDL003W | MCD1 | Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase | PDS3, RHC21, SCC1 | T |
| YAL040C | CLN3 | G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis | DAF1, FUN10, WHI1 | T |
| YGR044C | RME1 | Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation | CSP1 | F |
| YJL157C | FAR1 | Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate | | T |
| YPL016W | SWI1 | One of 11 subunits of the SWI/SNF chromatin remodeling complex that regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 | ADR6, GAM3, LPA1 | F |
| YER007C-A | TMA20 | Hypothetical protein | RBF20 | T |
| YDR347W | MRP1 | Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein | | T |
| YKL135C | APL2 | Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting | | F |
| YPR112C | MRD1 | Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains | | T |
| YOL149W | DCP1 | Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p | | T |
| YBR049C | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription | GRF2 | T |
| YDR382W | RPP2B | Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm | RPL45, YPA1 | T |
| YCL011C | GBP2 | Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro | RLF6 | T |
| YJL074C | SMC3 | Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member | | T |
| YDR120C | TRM1 | tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments | | T |
| YOL010W | RCL1 | RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity | | T |
| YOR116C | RPO31 | RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit | C160, RPC1, RPC160 | F |
| YCR046C | IMG1 | Mitochondrial ribosomal protein of the small subunit, required for respiration and for maintenance of the mitochondrial genome | | T |
| YDR447C | RPS17B | Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein | RP51B, RPL51B | T |
| YGR124W | ASN2 | Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway | | T |
| YOR269W | PAC1 | Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1 | | T |
| YHL004W | MRP4 | Mitochondrial ribosomal protein of the small subunit | | T |
| YLR380W | CSR1 | Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance | SFH2 | T |
| YKL068W | NUP100 | Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p | NSP100 | T |
| YBR202W | CDC47 | Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase | MCM7 | T |
| YLR196W | PWP1 | Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily | | T |
| YBR217W | ATG12 | Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy | APG12 | T |
| YLR187W | SKG3 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p | | T |
| YMR199W | CLN1 | G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) | | T |
| YGL171W | ROK1 | ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis | | T |
| YMR194W | RPL36A | N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA | RPL39B | T |
| YBR011C | IPP1 | Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase | PPA1 | T |
| YOR210W | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III | ABC10-beta | T |
| YBL027W | RPL19B | Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal | | T |
| YER154W | OXA1 | Translocase of the mitochondrial inner membrane, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; null is respiratory deficient | PET1402 | T |
| YHR076W | PTC7 | Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments | | T |
| YML093W | UTP14 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | | T |
| YLR354C | TAL1 | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate | | T |
| YFL023W | BUD27 | Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern | | T |
| YLR432W | IMD3 | Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed | | T |
| YLL021W | SPA2 | Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate | FUS6, PEA1 | T |
| YCL024W | KCC4 | Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p | | T |
| YHR111W | UBA4 | Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response | YHR1 | T |
| YOR188W | MSB1 | Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4 | | T |
| YHL034C | SBP1 | Nucleolar single-strand nucleic acid binding protein; associates with small nuclear RNAs | SSB1, SSBR1 | T |
| YBR198C | TAF5 | Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification | TAF90, TafII90 | T |
| YDR121W | DPB4 | Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing | | T |
| YDR091C | RLI1 | Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase | | T |
| YHR201C | PPX1 | Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix | | T |
| YEL046C | GLY1 | Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis | | T |
| YBR084W | MIS1 | Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase | | T |
| YAR073W | IMD1 | Nonfunctional protein with homology to IMP dehydrogenase; IMD1 is a probable pseudogene that is located close to the telomere and is not expressed at detectable levels | | T |
| YPL198W | RPL7B | Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) | | T |
| YKL078W | DHR2 | Predominantly nucleolar DEAH-box RNA helicase, required for 18S rRNA synthesis | | T |
| YGR030C | POP6 | Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends | | T |
| YDR465C | RMT2 | Arginine methyltransferase; ribosomal protein L12 is a substrate | | T |
| YML071C | COG8 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments | DOR1 | T |
| YMR309C | NIP1 | Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection | | T |
| YGL031C | RPL24A | Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate | RPL30A | T |
| YBR015C | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment | CRV4, LDB8, TTP1 | T |
| YMR091C | NPL6 | Nuclear protein that may have a role in nuclear protein import and maintenance of proper telomere length | | T |
| YFL004W | VTC2 | Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion | PHM1 | T |
| YLR367W | RPS22B | Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins | | T |
| YOR209C | NPT1 | Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus | | T |
| YPR145W | ASN1 | Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway | | T |
| YNL220W | ADE12 | Adenylosuccinate synthase, catalyzes the first committed step in the 'de novo' biosynthesis of adenosine | BRA9 | T |
| YBR009C | HHF1 | One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity | | T |
| YCR047C | BUD23 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern | | T |
| YOR231W | MKK1 | Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p | SSP32 | T |
| YJR127C | RSF2 | Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions | ZMS1 | T |
| YPR190C | RPC82 | RNA polymerase III subunit C82 | C82, RPC3 | T |
| YDR045C | RPC11 | RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription | C11 | T |
| YAR008W | SEN34 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease | FUN4 | T |
| YMR079W | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs | PIT1 | T |
| YNL111C | CYB5 | Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation | | T |
| YPL173W | MRPL40 | Mitochondrial ribosomal protein of the large subunit | YmL40 | T |
| YGL049C | TIF4632 | Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p | | T |
| YNR009W | NRM1 | Putative transcriptional repressor of MBF (MCB binding factor) target genes | | T |
| YGL013C | PDR1 | Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes | AMY1, ANT1, BOR2, CYH3, NRA2, SMR2, TIL1, TPE1, TPE3 | T |
| YER165W | PAB1 | Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G | | T |
| YPL083C | SEN54 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p | | T |
| YAL039C | CYC3 | Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-Cyc1p in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) | | T |
| YOR355W | GDS1 | Protein of unknown function, required for growth on glycerol as a carbon source | | T |
| YJL158C | CIS3 | Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family | CCW11, CCW5, PIR4 | T |
| YJL050W | MTR4 | Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA | DOB1 | T |