| ID | Symbol | Description | Aliases | Front Node |
| YBR188C | NTC20 | Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing | | F |
| YLR025W | SNF7 | One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes | DID1, VPS32 | T |
| YJR022W | LSM8 | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA | | T |
| YOR261C | RPN8 | Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p | | T |
| YER180C | ISC10 | Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells | | T |
| YER050C | RSM18 | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein | | T |
| YBR251W | MRPS5 | Mitochondrial ribosomal protein of the small subunit | | T |
| YPL118W | MRP51 | Mitochondrial ribosomal protein of the large subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences | | T |
| YDR073W | SNF11 | One of 11 subunits of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p | | T |
| YBR201W | DER1 | Endoplasmic reticulum membrane protein, required for ER-associated protein degradation, involved in the retrograde transport of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p | | T |
| YMR001C | CDC5 | Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate | MSD2, PKX2 | T |
| YDR383C | NKP1 | Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) | | T |
| YNL031C | HHT2 | One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation | | T |
| YNL147W | LSM7 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA | | T |
| YJL051W | YJL051W | Protein of unknown function, localized to the bud tip; mRNA is targeted to the bud via the mRNA transport system involving She2p | | F |
| YOR148C | SPP2 | Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction | | T |
| YHR184W | SSP1 | Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis | SPO3 | T |
| YGR005C | TFG2 | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 | | T |
| YLR323C | CWC24 | Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p | | T |
| YAL032C | PRP45 | Ortholog of human transcriptional coactivator SKIP, can activate transcription of a reporter gene; interacts with splicing factors Prp22p and Prp46p | FUN20 | F |
| YPR143W | RRP15 | Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNA | | T |
| YPL124W | SPC29 | Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication | LPH3, NIP29 | T |
| YOR205C | FMP38 | The authentic, non-tagged protein was localized to the mitochondria | | T |
| YNL059C | ARP5 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes | | T |
| YGL174W | BUD13 | Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern | CWC26 | T |
| YDR136C | VPS61 | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect | | F |
| YGL021W | ALK1 | Putative Ser-Thr protein kinase, belongs to the haspin family of kinases; contains a leucine zipper motif; may function in mitosis | | T |
| YGR108W | CLB1 | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome | SCB1 | T |
| YER013W | PRP22 | DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes | | F |
| YDR088C | SLU7 | RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain | SLT17 | T |
| YPL255W | BBP1 | Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p | | T |
| YPR057W | BRR1 | snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed | | T |
| YPR101W | SNT309 | component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p | | T |
| YGR072W | UPF3 | Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance | SUA6 | T |
| YKR022C | NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly | | T |
| YFL017C | GNA1 | Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA | PAT1 | T |
| YNL149C | PGA2 | Essential protein required for maturation of Gas1p and Pho8p; GFP-fusion protein localizes to the endoplasmic reticulum (ER) and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect | | T |
| YPR115W | YPR115W | Hypothetical protein | | F |
| YER092W | IES5 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions | | T |
| YIR010W | DSN1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation | | T |
| YDR386W | MUS81 | Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p | SLX3 | T |
| YNL252C | MRPL17 | Mitochondrial ribosomal protein of the large subunit | MRPL30, YmL30 | T |
| YNL188W | KAR1 | Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p | | T |
| YOR064C | YNG1 | Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; has similarity to the human tumor suppressor ING1 | YOR29-15 | T |
| YOR189W | IES4 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions | | T |
| YPL209C | IPL1 | Aurora kinase involved in regulating kinetochore-microtubule attachments, associates with Sli5p, which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle, potential Cdc28p substrate | PAC15 | T |
| YBR098W | MMS4 | Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair | SLX2, YBR100W | T |
| YLR026C | SED5 | cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins | | T |
| YMR112C | MED11 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme | | T |
| YNL227C | JJJ1 | Protein that contains a 70 amino acid J-domain, may function as a co-chaperone to recruit Hsp70-like activity to specific sites; mutation causes defects in fluid-phase endocytosis | | T |
| YJL140W | RPB4 | RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance | B32, CTF15 | T |
| YGR253C | PUP2 | Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta | DOA5 | T |
| YBL090W | MRP21 | Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences | MRP50 | T |
| YDR179C | CSN9 | Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling | | T |
| YJR135C | MCM22 | Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner | | T |
| YDL030W | PRP9 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex | | F |
| YDL115C | IWR1 | Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin | | T |
| YGR230W | BNS1 | Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis | | T |
| YPR108W | RPN7 | Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits | | T |
| YDR229W | IVY1 | Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase | | F |
| YOL143C | RIB4 | Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin | | T |
| YIR005W | IST3 | Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing | SNU17 | F |
| YOR115C | TRS33 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic | | T |
| YBR119W | MUD1 | U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing | U1-A, U1A | T |
| YDR113C | PDS1 | Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei | | T |
| YAL047C | SPC72 | Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization | LDB4 | T |
| YKL003C | MRP17 | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator | | T |
| YPR182W | SMX3 | Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F | Sm F, SmF | F |
| YNR036C | YNR036C | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli and human mitochondrial S12 ribosomal proteins | | F |
| YJL115W | ASF1 | Nucleosome assembly factor, involved in chromatin assembly after DNA replication, anti-silencing protein that causes derepression of silent loci when overexpressed | CIA1 | T |
| YGR215W | RSM27 | Mitochondrial ribosomal protein of the small subunit | | T |
| YNL167C | SKO1 | Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in the osmotic and oxidative stress responses | ACR1 | F |
| YBR146W | MRPS9 | Mitochondrial ribosomal protein of the small subunit | | T |
| YBR107C | IML3 | Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p | MCM19 | F |
| YLR421C | RPN13 | Subunit of the 19S regulatory particle of the 26S proteasome lid | | T |
| YOR194C | TOA1 | TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA | | T |
| YDL002C | NHP10 | Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex | HMO2 | T |
| YHR124W | NDT80 | Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) | | F |
| YNL215W | IES2 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions | | T |
| YJR144W | MGM101 | Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage | MGM9 | T |
| YDR033W | MRH1 | Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; has similarity to Hsp30p and Yro2p, which are induced during heat shock | | T |
| YHR102W | KIC1 | Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body | NRK1 | T |
| YBR267W | REI1 | Protein of unknown function involved in bud growth in the mitotic signaling network; proposed negative regulator of Swe1p and Gin4p; contains dispersed C2H2 zinc finger domains | | T |
| YPR166C | MRP2 | Mitochondrial ribosomal protein of the small subunit | | T |
| YDR482C | CWC21 | Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p | | F |
| YBR065C | ECM2 | Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p | SLT11 | F |
| YML064C | TEM1 | GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis | | F |
| YPL024W | RMI1 | Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III) | NCE4 | T |
| YGL070C | RPB9 | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance | B12.6, SHI1, SSU73 | T |
| YOR276W | CAF20 | Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E | CAF2, CAP20, p20 | T |
| YDR184C | ATC1 | Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern | LIC4 | T |
| YPL241C | CIN2 | Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl | | T |
| YGR091W | PRP31 | Splicing factor, component of the U4/U6-U5 snRNP complex | | T |
| YDR139C | RUB1 | Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) | | T |
| YNL079C | TPM1 | Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently | tropomyosin | T |
| YNR011C | PRP2 | RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing | RNA2 | T |
| YDL053C | PBP4 | Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system | | F |
| YMR158W | MRPS8 | Mitochondrial ribosomal protein of the small subunit | | T |
| YDR477W | SNF1 | AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis | CAT1, CCR1, GLC2, HAF3, PAS14 | F |
| YHR121W | LSM12 | Protein containing an Lsm domain and an AD domain; may bind RNA and have a role in RNA processing | | F |
| YBR253W | SRB6 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation | MED22 | T |
| YNL233W | BNI4 | Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p | | T |
| YOR061W | CKA2 | Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases | YOR29-12 | F |
| YNL166C | BNI5 | Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner | | T |
| YPL129W | TAF14 | Subunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domain | ANC1, SWP29, TAF30, TFG3, TafII30 | F |
| YNL005C | MRP7 | Mitochondrial ribosomal protein of the large subunit | MRPL2, YmL2 | T |
| YMR077C | VPS20 | Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes | CHM6 | T |
| YOR216C | RUD3 | Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 | GRP1 | T |
| YGR084C | MRP13 | Mitochondrial ribosomal protein of the small subunit | | T |
| YFL038C | YPT1 | Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) | YP2 | T |
| YGR129W | SYF2 | Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression | NTC31 | T |
| YLR119W | SRN2 | Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus | SRN10, VPS37 | T |
| YOR372C | NDD1 | Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes | | F |
| YGR179C | OKP1 | Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly | | T |
| YOR195W | SLK19 | Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate | | T |
| YDR416W | SYF1 | Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein | NTC90 | F |
| YLR298C | YHC1 | Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site | U1-C, U1C | T |
| YDL219W | DTD1 | D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes | | T |
| YNL081C | SWS2 | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein | | T |
| YLR045C | STU2 | Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p | | T |