ID | Symbol | Description | Aliases | Front Node |
YML041C | VPS71 | Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; required for vacuolar protein sorting | SWC6 | T |
YGL181W | GTS1 | Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport | FHT1, LSR1 | T |
YOR275C | RIM20 | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; member of the PalA/AIP1/Alix family; interacts with the ESCRT-III subunits Snf7p, suggesting a relationship between the response to pH and multivesicular body formation | | T |
YKR098C | UBP11 | Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins | | T |
YBR006W | UGA2 | Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm | UGA5 | T |
YDR213W | UPC2 | Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog | MOX4 | F |
YKL119C | VPH2 | Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) | CLS10, VMA12 | F |
YDL188C | PPH22 | Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis | PPH2 | T |
YGL180W | ATG1 | Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway | APG1, AUT3, CVT10 | T |
YML023C | NSE5 | Protein required for cell viability | | F |
YGL006W | PMC1 | Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium | | T |
YCL034W | LSB5 | Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization | | T |
YOR185C | GSP2 | GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability | CNR2 | T |
YMR297W | PRC1 | Vacuolar carboxypeptidase Y (proteinase C), involved in protein degradation in the vacuole and required for full protein degradation during sporulation | LBC1 | T |
YGL208W | SIP2 | One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane | SPM2 | T |
YDL181W | INH1 | Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures | | T |
YIL124W | AYR1 | NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER; involved in phosphatidic acid biosynthesis and required for spore germination; capable of metabolizing mammalian steroid hormones | | T |
YNL237W | YTP1 | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins | | T |
YML013W | SEL1 | UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, has a ubiquitin-associated (UBA) domain, interacts with ubiquitylated proteins in vivo, and is required for degradation of a ubiquitylated model substrate | UBX2 | T |
YML042W | CAT2 | Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes | YCAT | T |
YDL139C | SCM3 | Protein of unknown function; isolated as a high-copy suppressor of mutations in the histone fold domain (HFD) of CSE4 | | T |
YHR039C-A | VMA10 | Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification | YHR039BC, YHR039C-B | F |
YBR017C | KAP104 | Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression | | F |
YER101C | AST2 | Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions | | T |
YLR093C | NYV1 | v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane | MAM2 | T |
YER096W | SHC1 | Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH | | T |
YIL071C | PCI8 | Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain | CSN11, YIH1 | T |
YBR161W | CSH1 | Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p | | T |
YMR105C | PGM2 | Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase | GAL5 | T |
YMR030W | RSF1 | Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth | | T |
YPR026W | ATH1 | Acid trehalase required for utilization of extracellular trehalose | | T |
YPL154C | PEP4 | Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates | PHO9, PRA1, yscA | T |
YMR092C | AIP1 | Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats | | T |
YNL159C | ASI2 | Predicted membrane protein; genetic interactions suggest a role in negative regulation of amino acid uptake | | T |
YGL059W | YGL059W | Hypothetical protein | | F |
YDL110C | TMA17 | Hypothetical protein | | T |
YNL293W | MSB3 | GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth | GYP3 | T |
YJL102W | MEF2 | Mitochondrial elongation factor involved in translational elongation | | T |
YBR170C | NPL4 | Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation | HRD4 | T |
YFL030W | AGX1 | Alanine : glyoxylate aminotransferase, catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine : glyoxylate aminotransferases | | T |
YFR014C | CMK1 | Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II | | T |
YGR028W | MSP1 | Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase | YTA4 | T |
YML004C | GLO1 | Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress | | T |
YLR185W | RPL37A | Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein | | T |
YOR036W | PEP12 | Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin | VPL6, VPS6, VPT13 | T |
YDR486C | VPS60 | Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation | CHM5, MOS10 | F |
YHR043C | DOG2 | 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed | | T |
YGL005C | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments | COD5 | T |
YCR063W | BUD31 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern | CWC14 | T |
YHR115C | DMA1 | Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr | CHF1 | T |
YER053C | PIC2 | Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature | | T |
YJL001W | PRE3 | 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides | CRL21 | T |
YPR030W | CSR2 | Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate | MRG19 | T |
YLR181C | VTA1 | Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects | | T |
YMR040W | YET2 | Endoplasmic reticulum transmembrane protein, homolog of human BAP31 protein | | T |
YNL253W | TEX1 | Protein involved in mRNA export, component of the transcription export (TREX) complex | | T |
YOR208W | PTP2 | Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus | | T |
YPL249C | GYP5 | GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p | | T |
YDL013W | HEX3 | Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p | SLX5 | T |
YDL132W | CDC53 | Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation | | T |
YFR050C | PRE4 | 20S proteasome beta-type subunit | | T |
YIL010W | DOT5 | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth | nTPx | T |
YDL204W | RTN2 | Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily | | T |
YMR053C | STB2 | Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p | | T |
YLR102C | APC9 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition | | T |
YPL258C | THI21 | Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p | | T |
YDL193W | NUS1 | Prenyltransferase, required for cell viability | | T |
YNL117W | MLS1 | Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium | | T |
YNL173C | MDG1 | Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations | | T |
YLR423C | ATG17 | Protein that interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway | APG17 | T |
YNR035C | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin | END9 | F |
YDR436W | PPZ2 | Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance | | T |
YAL034C | FUN19 | Non-essential protein of unknown function | | T |
YKL023W | YKL023W | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm | | F |
YHR135C | YCK1 | Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p | CKI2 | F |
YHR016C | YSC84 | Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p | LSB4 | T |
YBR109C | CMD1 | Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin | | F |
YFL014W | HSP12 | Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways | GLP1, HOR5 | T |
YDL007W | RPT2 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle | YHS4, YTA5 | T |
YIL053W | RHR2 | Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress | GPP1 | T |
YFR008W | FAR7 | Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p | | T |
YJL036W | SNX4 | Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p | ATG24, CVT13 | T |
YOR176W | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; Yfh1p mediates the use of iron by Hem15p | | T |
YER063W | THO1 | Protein of unknown function; overproduction suppresses the transcriptional defect caused by an hpr1 mutation | | T |
YER143W | DDI1 | DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control | VSM1 | T |
YGR048W | UFD1 | Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol | | T |
YPL159C | PET20 | Protein required for respiratory growth and stability of the mitochondrial genome | | T |
YKL166C | TPK3 | Subunit of cytoplasmic cAMP-dependent protein kinase, which contains redundant catalytic subunits Tpk1p, Tpk2p, and Tpk3p and regulatory subunit Bcy1p; promotes vegetative growth in response to nutrients; inhibits filamentous growth | | F |
YLR125W | YLR125W | Hypothetical protein | | F |
YOR136W | IDH2 | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle | | T |
YMR025W | CSI1 | Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling | | T |
YOR137C | SIA1 | Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose | | T |
YIL062C | ARC15 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches | | T |
YOR128C | ADE2 | Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine | | T |
YKL182W | FAS1 | Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities | | F |
YJL153C | INO1 | Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element | APR1 | T |
YJR156C | THI11 | Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 | | T |
YPL031C | PHO85 | Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 | LDB15 | F |
YGL248W | PDE1 | Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation | | T |
YLR176C | RFX1 | Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins | CRT1 | T |
YNL094W | APP1 | Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization | | T |
YBL041W | PRE7 | 20S proteasome beta-type subunit | PRS3 | T |
YOR374W | ALD4 | Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed | ALD7 | T |
YJL146W | IDS2 | Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation | | F |
YJR001W | AVT1 | Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters | | F |
YJL066C | MPM1 | Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches | | T |
YPL166W | ATG29 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern | | T |
YHL030W | ECM29 | Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome | | T |
YMR311C | GLC8 | Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 | | T |
YPL003W | ULA1 | Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation | ENR2 | T |
YMR197C | VTI1 | Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways | | T |
YJR086W | STE18 | G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling | | T |
YDR092W | UBC13 | Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus | | T |
YMR110C | HFD1 | Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome | | T |
YGL209W | MIG2 | Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter | MLZ1 | F |
YER142C | MAG1 | 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired | MMS5 | T |
YOR075W | UFE1 | t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex | YOR29-26 | T |
YER175C | TMT1 | Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle | TAM1 | T |
YGR023W | MTL1 | Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations | | T |
YDR330W | UBX5 | UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p | | T |