| ID | Symbol | Description | Aliases | Front Node |
| YDR148C | KGD2 | Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA | | F |
| YGR136W | LSB1 | Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization | | T |
| YOL013C | HRD1 | Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger | DER3 | F |
| YPL265W | DIP5 | Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly | | T |
| YMR145C | NDE1 | Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain | NDH1 | T |
| YCR069W | CPR4 | Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway | CYP4, SCC3, YCR070W | T |
| YBR296C | PHO89 | Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p | ITN1 | T |
| YEL017W | GTT3 | Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery | | F |
| YHL042W | YHL042W | Putative protein of unknown function; not an essential gene | | F |
| YKL116C | PRR1 | Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway | | F |
| YDL146W | LDB17 | Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface | | T |
| YPR093C | ASR1 | Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain | | F |
| YLR287C | YLR287C | Hypothetical protein | | F |
| YGL009C | LEU1 | Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway | | T |
| YGL253W | HXK2 | Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene | HEX1, HKB, SCI2 | T |
| YGR193C | PDX1 | Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core | | T |
| YBR114W | RAD16 | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4); member of the SWI/SNF family | PSO5 | F |
| YBR185C | MBA1 | Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane | | T |
| YOL097C | WRS1 | Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA | HRE342 | T |
| YPL218W | SAR1 | GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport | | F |
| YKR067W | GPT2 | Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone, which are intermediate steps in lipid biosynthesis | GAT1 | F |
| YNL335W | DDI3 | Hypothetical protein | | T |
| YBR223C | TDP1 | Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I | | T |
| YDR127W | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids | | F |
| YML067C | ERV41 | Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport | | F |
| YLR089C | ALT1 | Putative alanine transaminase (glutamic pyruvic transaminase) | | T |
| YKL126W | YPK1 | Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK | SLI2 | F |
| YDL106C | PHO2 | Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p | BAS2, GRF10 | F |
| YLR133W | CKI1 | Choline kinase, catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway); mRNA expression is regulated by inositol and choline, enzyme activity is stimulated by phosphorylation by protein kinase | | T |
| YJR059W | PTK2 | Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake | STK2 | F |
| YFL018C | LPD1 | Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes | HPD1 | T |
| YDL224C | WHI4 | Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division | | T |
| YML028W | TSA1 | Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype | TPX1, ZRG14, cTPxI | T |
| YFL041W | FET5 | Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport | | T |
| YML007W | YAP1 | Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants | PAR1, SNQ3 | F |
| YDL142C | CRD1 | Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function | CLS1 | T |
| YDR498C | SEC20 | Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p | | F |
| YCL057W | PRD1 | Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins | | T |
| YLR429W | CRN1 | Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity | | T |
| YFR028C | CDC14 | Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit | OAF3 | F |
| YMR055C | BUB2 | Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage | PAC7 | F |
| YOR179C | SYC1 | Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs | | T |
| YKL018W | SWD2 | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination | CPS35, SAF37 | F |
| YHL009C | YAP3 | Basic leucine zipper (bZIP) transcription factor | | F |
| YLR286C | CTS1 | Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p | | T |
| YFR051C | RET2 | Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER | | T |
| YLR259C | HSP60 | Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL | CPN60, MIF4 | T |
| YGR089W | NNF2 | Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation | | F |
| YBR068C | BAP2 | High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains | | T |
| YJL094C | KHA1 | Putative K+/H+ antiporter | | T |
| YLR146C | SPE4 | Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid | | T |
| YLR144C | ACF2 | Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly | ENG2, PCA1 | F |
| YLR342W | FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling | CND1, CWH53, ETG1, GSC1, PBR1 | T |
| YJL092W | HPR5 | DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate | RADH, RADH1, SRS2 | F |
| YIL006W | YIA6 | Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs | NDT1 | T |
| YOL086C | ADH1 | Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway | ADC1 | T |
| YPR069C | SPE3 | Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells | | T |
| YDR359C | VID21 | Component of the NuA4 histone acetyltransferase complex | EAF1 | T |
| YCR037C | PHO87 | Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments | | T |
| YDR259C | YAP6 | Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance | HAL7 | F |
| YGR016W | YGR016W | Hypothetical protein | | F |
| YOR133W | EFT1 | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin | | T |
| YML085C | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules | | F |
| YLR191W | PEX13 | Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domain | PAS20 | F |
| YDR161W | YDR161W | interacts with PP2C | | F |
| YCL028W | RNQ1 | [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate | [PIN(+)] | T |
| YGL202W | ARO8 | Aromatic aminotransferase, expression is regulated by general control of amino acid biosynthesis | | T |
| YDL042C | SIR2 | Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication | MAR1 | F |
| YMR080C | NAM7 | ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance | IFS2, MOF4, UPF1 | F |
| YGR282C | BGL2 | Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance | | T |
| YPL028W | ERG10 | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis | LPB3, TSM0115 | T |