| ID | Symbol | Description | Aliases | Front Node |
| YMR059W | SEN15 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p | | F |
| YJR048W | CYC1 | Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration | | T |
| YMR228W | MTF1 | Mitochondrial RNA polymerase sigma-like specificity factor required for promoter recognition, interacts with mitochondrial core polymerase Rpo41p, imported into mitochondria via a novel process requiring most of the Mtf1p sequence | | F |
| YLR288C | MEC3 | DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 | PIP3 | F |
| YOL067C | RTG1 | Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus | | F |
| YLR466W | YRF1-4 | Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p | YRF1 | T |
| YFR041C | ERJ5 | Endoplasmic reticulum protein that may function as a cochaperone, as suggested by the presence of a DnaJ-like domain | | T |
| YGR092W | DBF2 | Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis | | F |
| YPL097W | MSY1 | Mitochondrial tyrosyl-tRNA synthetase | | T |
| YBR136W | MEC1 | Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination | ESR1, SAD3 | F |
| YPR113W | PIS1 | Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins | | T |
| YOR069W | VPS5 | Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p | GRD2, PEP10, VPT5, YOR29-20 | T |
| YLR068W | FYV7 | Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts | | T |
| YJL203W | PRP21 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly | SPP91 | F |
| YIL036W | CST6 | Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance | ACA2, SHF1 | T |
| YNL288W | CAF40 | Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p | | F |
| YJL104W | PAM16 | Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; has similarity to J-domain containing proteins | MIA1, TIM16 | T |
| YPL246C | RBD2 | Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p | | T |
| YOR181W | LAS17 | Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) | BEE1 | T |
| YML095C | RAD10 | Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein | | F |
| YML043C | RRN11 | Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p | | T |
| YLR382C | NAM2 | Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance | MSL1 | T |
| YPL248C | GAL4 | DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p | GAL81 | F |
| YEL071W | DLD3 | D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm | | T |
| YBR200W | BEM1 | Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p | SRO1 | F |
| YER088C | DOT6 | Protein of unknown function, involved in telomeric gene silencing and filamentation | | F |
| YNL204C | SPS18 | Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation | SPX18 | T |
| YGR262C | BUD32 | Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern | LDB14 | F |
| YJL010C | NOP9 | Essential nucleolar protein required for 18S rRNA synthesis | | T |
| YPL269W | KAR9 | Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase | | F |
| YDL153C | SAS10 | Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing | UTP3 | T |
| YOR233W | KIN4 | Nonessential protein kinase with unknown cellular role | KIN3, KIN31 | F |
| YDL149W | ATG9 | Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes | APG9, AUT9, CVT7 | F |
| YDR270W | CCC2 | Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases | | T |
| YMR049C | ERB1 | Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1 | | F |
| YBL005W | PDR3 | Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) | AMY2, TPE2 | F |
| YBL014C | RRN6 | Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein | | F |
| YLR292C | SEC72 | Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER | SEC67, SIM2 | F |
| YNL091W | NST1 | Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 | | T |
| YNL164C | IBD2 | Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p | | T |
| YML008C | ERG6 | Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24 | ISE1, LIS1, SED6 | T |
| YHL040C | ARN1 | Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores | | T |
| YPL155C | KIP2 | Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle | | T |
| YDR414C | ERD1 | Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) | LDB2 | F |
| YHL047C | ARN2 | Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C | TAF1 | T |
| YFL036W | RPO41 | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition | | T |
| YBR159W | YBR159W | Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides. | | F |
| YKL075C | YKL075C | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin | | F |
| YGR218W | CRM1 | Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus | KAP124, XPO1 | F |
| YNL242W | ATG2 | Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking | APG2, AUT8, SPO72 | T |
| YOL093W | TRM10 | tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs | | T |
| YHR011W | DIA4 | Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth | | T |
| YLR007W | NSE1 | Essential nuclear protein required for DNA repair; forms a complex with Smc5p and Smc6p | | T |
| YDL189W | RBS1 | Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain | | T |
| YNR026C | SEC12 | Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p | SED2 | T |
| YAL042W | ERV46 | Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport | FUN9 | T |
| YHR164C | DNA2 | Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate | WEB2 | T |
| YPL262W | FUM1 | Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation | | T |
| YNL292W | PUS4 | Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) | | T |
| YCR081W | SRB8 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression | GIG1, MED12, NUT6, SSN5, YCR080W | F |
| YPL038W | MET31 | Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met32p | | T |
| YKL101W | HSL1 | Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p | NIK1 | F |
| YGL105W | ARC1 | Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids | | T |
| YJL173C | RFA3 | Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination | | T |
| YMR021C | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport | CUA1 | F |
| YDR463W | STP1 | Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing | BAP1, SSY2 | F |
| YOR363C | PIP2 | Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes | OAF2 | F |
| YDR418W | RPL12B | Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins | | F |
| YGL090W | LIF1 | Protein involved in DNA double-strand break repair; physically interacts with DNA ligase 4 (Lig4p); homologous to mammalian XRCC4 protein | | T |
| YHR109W | CTM1 | Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth | | T |
| YDR211W | GCD6 | Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression | | F |
| YLR309C | IMH1 | Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi | SYS3 | T |
| YOR330C | MIP1 | Catalytic subunit of the mitochondrial DNA polymerase | | T |
| YLR347C | KAP95 | Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex | RSL1 | F |
| YPR086W | SUA7 | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II | SOH4, TFIIB | F |
| YPL132W | COX11 | Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p | LPI13, PSO7 | T |
| YOR326W | MYO2 | One of two type V myosins, involved in polarized distribution of mitochondria; required for mitochondrion and vacuole inheritance and nuclear spindle orientation; moves multiple cargo | CDC66 | T |
| YEL017C-A | PMP2 | Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1 | | T |
| YDR310C | SUM1 | Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint | | F |
| YHL007C | STE20 | Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases | | T |
| YKL043W | PHD1 | Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate | | T |
| YGL023C | PIB2 | Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27 | | T |