How cells decide on their fate? (OR: Challenges in single cell imaging informatics)

Iftach Nachman, TAU

Abstract:

How do cells decide on to switch their state? Why do similar cells make different decisions? I will describe two projects dealing with this question in two systems: entry into meiosis in yeast cells, and reprogramming to pluripotency in mammalian cells. The projects are based on high-throughput live cell imaging of the processes. I will emphasize computational questions: What can we learn from single cell image data? What computational challenges are involved? What computational tools can we use?