GO biological process

Confidently predicted functions (FDR<0.1):

GO term	FAME p-value	FAME q-value	FAME z-score	FAME enrichment factor	Targets with function	HG p-value	Genes with function
oligodendrocyte differentiation	0.0002	0.0894	5.27	6.86	3	0.047017775	NF1,PLP1,SOX10

Less confident functions (FDR>0.1, p-value<0.05):

GO term	FAME p-value	FAME q-value	FAME z-score	FAME enrichment factor	Targets with function	HG p-value	Genes with function
RNA splicing	0.0007	0.1937	3.49	1.84	21	0.013642036	DHX16,GEMIN8,HNRPA3,HNRPF,HNRPU,LSM2,LSM7, MBNL1,P18SRP,PABPC1,PRPF40A,PTBP1,PTBP2,SFPQ,SFRS1, SFRS2IP,SNRP70,SRrp35,WBP11,WTAP,ZRANB2
rRNA metabolism	0.0009	0.1689	4.66	6.87	4	0.072500475	EXOSC7,KIAA0179,NOLC1,WBP11
mRNA metabolism	0.0013	0.1937	3.14	1.61	29	0.0032813454	AUH,DHX16,GEMIN8,GRSF1,HNRPA3,HNRPF,HNRPU, LSM2,LSM7,MBNL1,P18SRP,PABPC1,PABPC3,PAIP1,PARN, PRPF40A,PTBP1,PTBP2,ROD1,SFPQ,SFRS1,SFRS2IP,SLBP, SNRP70,SRrp35,WBP11,WTAP,ZFP36L1,ZRANB2
mRNA processing	0.0014	0.1609	3.30	1.72	24	0.010696755	DHX16,GEMIN8,GRSF1,HNRPA3,HNRPF,HNRPU,LSM2, LSM7,MBNL1,P18SRP,PABPC1,PRPF40A,PTBP1,PTBP2,ROD1, SFPQ,SFRS1,SFRS2IP,SLBP,SNRP70,SRrp35,WBP11,WTAP, ZRANB2
RNA processing	0.0025	0.2434	3.00	1.56	29	0.039089937	C1orf25,DHX16,EXOSC7,GEMIN8,GRSF1,HNRPA3,HNRPF, HNRPU,INTS5,KIAA0179,LSM2,LSM7,MBNL1,NOLC1,P18SRP, PABPC1,PRPF40A,PTBP1,PTBP2,ROD1,SFPQ,SFRS1,SFRS2IP, SLBP,SNRP70,SRrp35,WBP11,WTAP,ZRANB2
ribosome biogenesis and assembly	0.0033	0.2852	3.75	5.05	4	0.15928765	EXOSC7,KIAA0179,NOLC1,WBP11
spliceosome assembly	0.0056	0.4172	2.97	2.74	4	0.084788814	MBNL1,SFRS1,SFRS2IP,SRrp35
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	0.0060	0.3973	2.71	1.89	12	0.073991776	GEMIN8,HNRPA3,HNRPF,HNRPU,LSM2,LSM7,MBNL1, PTBP1,SFRS1,SFRS2IP,SNRP70,SRrp35
mRNA splice site selection	0.0067	0.3993	2.91	2.87	3	0.0759237	MBNL1,SFRS1,SRrp35
translational initiation	0.0071	0.3820	2.76	2.20	9	0.009085182	DAZL,DENR,EIF2S1,EIF2S3,EIF3S6,EIF4A2,EIF4B, EIF5,PAIP1
meiotic cell cycle	0.0083	0.4122	2.81	2.61	6	0.12099501	DAZL,DMC1,FBXO43,MLH3,RAD21,STAG2
phospholipid transport	0.0090	0.4126	2.84	3.00	3	0.1108313	ATP11A,ATP8B1,ATP8B2
RNA metabolism	0.0118	0.5023	2.41	1.40	34	0.069203794	AUH,C1orf25,DHX16,EXOSC7,GEMIN8,GRSF1,HNRPA3, HNRPF,HNRPU,INTS5,KIAA0179,LSM2,LSM7,MBNL1,NOLC1, P18SRP,PABPC1,PABPC3,PAIP1,PARN,PRPF40A,PTBP1,PTBP2, ROD1,SFPQ,SFRS1,SFRS2IP,SLBP,SNRP70,SRrp35,WBP11, WTAP,ZFP36L1,ZRANB2
GPI anchor metabolism	0.0119	0.4708	2.74	3.27	3	0.13021454	PIGA,PIGK,PIGX
leukocyte migration	0.0128	0.4768	2.55	2.51	6	0.01628991	B4GALT1,CX3CL1,FOXJ1,MSN,PRKCA,VCAM1
glial cell differentiation	0.0148	0.5189	2.44	2.24	5	0.10715122	FGF5,IGF1,NF1,PLP1,SOX10
L-amino acid transport	0.0165	0.5447	2.80	4.14	3	0.09269059	HD,SLC1A4,SLC7A8
response to DNA damage stimulus	0.0198	0.6195	2.18	1.51	20	0.08625253	ANKRD17,BRIP1,CHES1,DCLRE1A,DYRK2,EPC2,ERCC5, ESCO2,FANCF,HIPK2,MAPK1,MLH3,MYO6,POLS,RAD21, RAD23B,SFPQ,SMC6,UBE2N,UVRAG
interleukin-2 biosynthesis	0.0201	0.5975	2.27	3.74	3	0.060685802	CD28,IL17F,IL18
translation	0.0205	0.5818	2.22	1.82	11	0.07055458	DAZL,DENR,EIF2S1,EIF2S3,EIF3S6,EIF4A2,EIF4B, EIF5,PAIP1,RPL15,SLA/LP
phospholipid biosynthesis	0.0235	0.6353	2.16	1.91	5	0.40747854	AGPAT5,ETNK1,PIGA,PIGK,PIGX
regulation of T cell proliferation	0.0244	0.6323	2.08	2.81	4	0.084788814	CD28,FOXJ1,IL18,VCAM1
metanephros development	0.0247	0.6121	2.18	2.08	5	0.041083504	BDNF,NF1,PAX2,SIX2,SMAD4
DNA repair	0.0251	0.5984	2.04	1.62	15	0.12778127	ANKRD17,BRIP1,DCLRE1A,EPC2,ERCC5,ESCO2,FANCF, MLH3,POLS,RAD21,RAD23B,SFPQ,SMC6,UBE2N,UVRAG
regulation of translational initiation	0.0255	0.5845	2.17	2.14	6	0.02789629	DAZL,EIF2S1,EIF3S6,EIF4A2,EIF4B,EIF5
biosynthesis	0.0311	0.6854	1.90	1.22	63	0.22650291	AADAT,AASDHPPT,ADCY6,AGL,AGPAT5,ATP11A,ATP6V1C1, ATP8B1,ATP8B2,AZIN1,B4GALT1,CD28,COL5A1,CYLD,DAZL, DENR,DYRK2,EIF2S1,EIF2S3,EIF3S6,EIF4A2,EIF4B,EIF5, ETNK1,EXT2,FLJ16237,FOXJ1,GHRH,GOT2,HD,IGF1, IGF2BP1,IL17F,IL18,INSR,LASS6,MGC4655,MMAB,MRPL19, MRPL3,MRPL49,MRPS25,NGDN,NME4,OGT,PAIP1,PBEF1, PIGA,PIGK,PIGX,PLP1,POFUT1,PPP1R15B,RP2,RPL15, SEC14L2,SERP1,SLA/LP,SPTLC1,ST8SIA1,UGDH,XYLT1,ZFP36L1
spermatid differentiation	0.0313	0.6652	2.17	2.56	4	0.05092156	CASC5,CEP57,DMC1,STRBP
post-Golgi vesicle-mediated transport	0.0313	0.6433	2.16	2.54	3	0.15058568	DOPEY2,EXOC5,RAB14
gastrulation	0.0314	0.6228	2.00	1.78	7	0.029897455	ACVR2A,BMPR2,EXT2,HD,SMAD2,SMAD4,UGDH
double-strand break repair	0.0314	0.6037	2.21	2.74	4	0.12715423	BRIP1,POLS,RAD21,UBE2N
regulation of translation	0.0322	0.5997	2.05	1.96	7	0.029897455	DAZL,EIF2S1,EIF3S6,EIF4A2,EIF4B,EIF5,SLA/LP
meiosis I	0.0327	0.5915	2.25	3.20	3	0.13021454	DMC1,MLH3,RAD21
membrane lipid biosynthesis	0.0329	0.5758	1.96	1.70	7	0.3593971	AGPAT5,ETNK1,LASS6,PIGA,PIGK,PIGX,ST8SIA1
cellular biosynthesis	0.0332	0.5653	1.85	1.23	58	0.14344627	AASDHPPT,ADCY6,AGL,ATP11A,ATP6V1C1,ATP8B1,ATP8B2, AZIN1,B4GALT1,CD28,COL5A1,CYLD,DAZL,DENR,DYRK2, EIF2S1,EIF2S3,EIF3S6,EIF4A2,EIF4B,EIF5,ETNK1,EXT2, FLJ16237,FOXJ1,GHRH,GOT2,HD,IGF1,IGF2BP1,IL17F, IL18,MGC4655,MMAB,MRPL19,MRPL3,MRPL49,MRPS25,NGDN, NME4,OGT,PAIP1,PBEF1,PIGA,PIGK,PIGX,PLP1, POFUT1,PPP1R15B,RP2,RPL15,SEC14L2,SERP1,SLA/LP,ST8SIA1, UGDH,XYLT1,ZFP36L1
sensory perception of sound	0.0343	0.5679	1.92	1.59	11	0.105980024	ANKH,ERCC5,IGF1,MYO6,OPA1,PTPN11,RDX, SLC17A8,SLC19A2,SOX10,SPRY2
cell-cell adhesion	0.0361	0.5815	1.89	1.50	14	0.16215998	CD164,CLDN22,CLSTN1,CTNND2,CX3CL1,DLG1,DSC3, FAT3,MSN,NLGN1,NPHP1,PCDH19,PKHD1,VCAM1
cortical cytoskeleton organization and biogenesis	0.0366	0.5740	2.03	2.39	4	0.010616459	DLG1,EPB41,EPB41L1,LLGL1
positive regulation of transcription from RNA polymerase II promoter	0.0373	0.5708	1.84	1.29	27	0.006344087	CHX10,FOXO3A,IGF1,IHH,IL17F,KLF12,KLF13, MKL2,MYO6,NCOA1,NFIB,NPAS2,PAX2,PKNOX1,PPARA, SIX2,SMAD2,SMAD4,SOX10,SOX8,SOX9,SP1,TCF7L1, TEAD1,TEAD3,THRAP1,ZFPM2
sensory perception of mechanical stimulus	0.0378	0.5640	1.87	1.57	11	0.13438587	ANKH,ERCC5,IGF1,MYO6,OPA1,PTPN11,RDX, SLC17A8,SLC19A2,SOX10,SPRY2
nucleotide-excision repair	0.0382	0.5546	2.13	3.01	3	0.26392278	DCLRE1A,ERCC5,RAD23B
establishment and/or maintenance of cell polarity	0.0384	0.5442	1.96	1.93	7	0.013623562	CDC42,CLASP1,DLG1,FOXJ1,LLGL1,MAP7,PRICKLE2
bone remodeling	0.0406	0.5620	1.81	1.46	13	0.04737056	ACVR2A,ANKH,AXIN2,BMPR2,CARTPT,CASR,DLX5, EXT2,IHH,NF1,SP1,SP3,TOB1
polysaccharide biosynthesis	0.0416	0.5635	2.09	2.88	3	0.17195663	AGL,DYRK2,EXT2
DNA damage response, signal transduction	0.0439	0.5814	1.85	1.81	5	0.13213484	BRIP1,CHES1,DYRK2,HIPK2,MYO6
macromolecule biosynthesis	0.0441	0.5720	1.74	1.26	41	0.03118372	AASDHPPT,AGL,B4GALT1,CD28,COL5A1,CYLD,DAZL, DENR,DYRK2,EIF2S1,EIF2S3,EIF3S6,EIF4A2,EIF4B,EIF5, EXT2,FOXJ1,IGF1,IGF2BP1,IL17F,IL18,MGC4655,MRPL19, MRPL3,MRPL49,MRPS25,NGDN,OGT,PAIP1,PIGA,PIGK, PIGX,POFUT1,PPP1R15B,RPL15,SERP1,SLA/LP,ST8SIA1,UGDH, XYLT1,ZFP36L1
mesoderm development	0.0444	0.5630	1.83	1.80	7	0.05586175	ACVR2A,BMPR2,BTK,EXT2,HD,SMAD2,TCF7L1
tissue remodeling	0.0444	0.5519	1.77	1.44	14	0.06123688	ACVR2A,ANKH,AXIN2,BMPR2,CARTPT,CASR,DLX5, EXT2,F2R,IHH,NF1,SP1,SP3,TOB1
M phase	0.0455	0.5540	1.85	1.45	19	0.054491464	APRIN,CCNB1,CD28,CEP55,CLASP1,DAZL,DCLRE1A, DMC1,FBXO43,HMGA2,IGF1,MLH3,NOLC1,POLS,RAD21, SCC-112,STAG2,TCF7L1,TGFA
protein biosynthesis	0.0465	0.5543	1.71	1.29	34	0.043698102	B4GALT1,CD28,COL5A1,CYLD,DAZL,DENR,EIF2S1, EIF2S3,EIF3S6,EIF4A2,EIF4B,EIF5,FOXJ1,IGF2BP1,IL17F, IL18,MGC4655,MRPL19,MRPL3,MRPL49,MRPS25,NGDN,OGT, PAIP1,PIGA,PIGK,PIGX,POFUT1,PPP1R15B,RPL15,SERP1, SLA/LP,ST8SIA1,ZFP36L1
lysosomal transport	0.0480	0.5609	1.88	2.27	3	0.1108313	ARSB,HMG2L1,NEDD4
phosphoinositide biosynthesis	0.0484	0.5547	1.86	2.27	3	0.24035174	PIGA,PIGK,PIGX
regulation of calcium ion transport	0.0492	0.5538	1.96	2.78	3	0.15058568	CASR,PLN,SLN
glycosaminoglycan metabolism	0.0499	0.5507	1.83	2.03	5	0.0651941	ARSB,EXT2,GNS,UGDH,XYLT1

KEGG pathways

Less confident functions (FDR>0.1, p-value<0.05):

KEGG pathway	FAME p-value	FAME q-value	FAME z-score	FAME enrichment factor	Targets with function	HG p-value	q-value	Genes with function
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	0.0100	0.4800	4.31	6.56	3	0.060074504	PIGA,PIGK,PIGX
Adherens junction	0.0150	0.3600	2.44	1.69	10	0.042119615	ACVR1C,CDC42,CREBBP,INSR,MAPK1,SMAD2,SMAD4, TCF7L1,WASF3,WASL

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