Supplementary website for

DEGAS: De novo discovery of dysregulated pathways in human diseases

Igor Ulitsky1,*, Akshay Krishnamurthy2, Richard M. Karp3, and Ron Shamir1


1 Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
2 University of California, Berkeley, University Avenue, Berkeley, CA 94720
3 International Computer Science Institute, 1947 Center St., Berkeley, CA 94704
* Current address: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge MA, USA 02142

An implementation of DEGAS which can be applied to network and gene expression data is available as part of MATISSE

. Each of the resulting dysregulated pathways listed below can be loaded in MATISSE as a session .zip file which contains all the relevant information, including network topology, gene expression, annotations etc.

Disease dysregulated pathways:

DatasetDisease (KEGG)DataDirectionMATISSE sessionkSizeGenesNetworkRaw dataExpression HeatmapDysregulation matrixDysregulation Heatmap
HDHuntington's diseaseGEODown regulatedsession .zip file2030Gene list.sif fileText fileImageText fileImage
HDHuntington's diseaseGEODifferentially expressedsession .zip file1521Gene list.sif fileText fileImageText fileImage
HDHuntington's diseaseGEOUp regulatedsession .zip file3061Gene list.sif fileText fileImageText fileImage
SLESystemic lupus erythematosusGEODown regulatedsession .zip file1530Gene list.sif fileText fileImageText fileImage
SLESystemic lupus erythematosusGEODifferentially expressedsession .zip file3068Gene list.sif fileText fileImageText fileImage
SLESystemic lupus erythematosusGEOUp regulatedsession .zip file2560Gene list.sif fileText fileImageText fileImage
SUN-GLIOBLASTOMAPathways in cancerGEODown regulatedsession .zip file2020Gene list.sif fileText fileImageText fileImage
SUN-GLIOBLASTOMAPathways in cancerGEODifferentially expressedsession .zip file2526Gene list.sif fileText fileImageText fileImage
SUN-GLIOBLASTOMAPathways in cancerGEOUp regulatedsession .zip file3030Gene list.sif fileText fileImageText fileImage
SUN-ASTROCYTOMAPathways in cancerGEODown regulatedsession .zip file55Gene list.sif fileText fileImageText fileImage
SUN-ASTROCYTOMAPathways in cancerGEODifferentially expressedsession .zip file1516Gene list.sif fileText fileImageText fileImage
SUN-ASTROCYTOMAPathways in cancerGEOUp regulatedsession .zip file1516Gene list.sif fileText fileImageText fileImage
SUN-OLIGODENDROGLIOMAPathways in cancerGEODown regulatedsession .zip file1010Gene list.sif fileText fileImageText fileImage
SUN-OLIGODENDROGLIOMAPathways in cancerGEODifferentially expressedsession .zip file1010Gene list.sif fileText fileImageText fileImage
SUN-OLIGODENDROGLIOMAPathways in cancerGEOUp regulatedsession .zip file2527Gene list.sif fileText fileImageText fileImage
ESTILO-OTSCCPathways in cancerGEODown regulatedsession .zip file3087Gene list.sif fileText fileImageText fileImage
ESTILO-OTSCCPathways in cancerGEODifferentially expressedsession .zip file2041Gene list.sif fileText fileImageText fileImage
ESTILO-OTSCCPathways in cancerGEOUp regulatedsession .zip file3056Gene list.sif fileText fileImageText fileImage
YE-OTSCCPathways in cancerGEODown regulatedsession .zip file58Gene list.sif fileText fileImageText fileImage
YE-OTSCCPathways in cancerGEODifferentially expressedsession .zip file2537Gene list.sif fileText fileImageText fileImage
YE-OTSCCPathways in cancerGEOUp regulatedsession .zip file3051Gene list.sif fileText fileImageText fileImage
MORAN-PDParkinson's diseaseGEODown regulatedsession .zip file3067Gene list.sif fileText fileImageText fileImage
MORAN-PDParkinson's diseaseGEODifferentially expressedsession .zip file3064Gene list.sif fileText fileImageText fileImage
MORAN-PDParkinson's diseaseGEOUp regulatedsession .zip file3073Gene list.sif fileText fileImageText fileImage
LESNICK-PDParkinson's diseaseGEODown regulatedsession .zip file57Gene list.sif fileText fileImageText fileImage
LESNICK-PDParkinson's diseaseGEODifferentially expressedsession .zip file3048Gene list.sif fileText fileImageText fileImage
LESNICK-PDParkinson's diseaseGEOUp regulatedsession .zip file2537Gene list.sif fileText fileImageText fileImage
ASTHMAAsthmaGEODown regulatedsession .zip file30139Gene list.sif fileText fileImageText fileImage
ASTHMAAsthmaGEODifferentially expressedsession .zip file30109Gene list.sif fileText fileImageText fileImage
ASTHMAAsthmaGEOUp regulatedsession .zip file25102Gene list.sif fileText fileImageText fileImage
ADAlzheimer's diseaseGEODown regulatedsession .zip file2525Gene list.sif fileText fileImageText fileImage
ADAlzheimer's diseaseGEODifferentially expressedsession .zip file3030Gene list.sif fileText fileImageText fileImage
ADAlzheimer's diseaseGEOUp regulatedsession .zip file3030Gene list.sif fileText fileImageText fileImage
PYLORIEpithelial cell signaling in Helicobacter pylori infectionGEODown regulatedsession .zip file1520Gene list.sif fileText fileImageText fileImage
PYLORIEpithelial cell signaling in Helicobacter pylori infectionGEODifferentially expressedsession .zip file2023Gene list.sif fileText fileImageText fileImage
PYLORIEpithelial cell signaling in Helicobacter pylori infectionGEOUp regulatedsession .zip file2022Gene list.sif fileText fileImageText fileImage

For questions, contact Igor Ulitsky