BPM 129
IDSymbolDescriptionAliases
YGR116WSPT6Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongationCRE2, SSN20
YDL140CRPO21RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-primeB220, RPB1, RPB220, SUA8
YGL043WDST1General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sitesP37, PPR2, S-II, SII, TFIIS
YML069WPOB3Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
YPL042CSSN3Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repressionCDK8, GIG2, NUT7, RYE5, SRB10, UME5
YPR052CNHP6AHigh-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YPL129WTAF14Subunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domainANC1, SWP29, TAF30, TFG3, TafII30
YOL005CRPB11RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunitB12.5
YGL070CRPB9RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenanceB12.6, SHI1, SSU73
YBR236CABD1Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YGL244WRTF1Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenanceCSL3
YPL228WCET1Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptideCES5
YIL021WRPB3RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunitB44
YGL207WSPT16Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structureCDC68, SSF1
YLR418CCDC73Substituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
YPR086WSUA7Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase IISOH4, TFIIB
YHR143W-ARPC10RNA polymerase subunit, found in RNA polymerase complexes I, II, and IIIABC10-alpha, RPB12
YBR154CRPB5RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivationABC27
YOR151CRPB2RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunitB150, RPB150, RPO22, SIT2, SOH2
YGR063CSPT4Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
YPR133CSPN1Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotypeIWS1
YGL130WCEG1Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YGR005CTFG2TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
YML010WSPT5Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
YIL035CCKA1Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YDL108WKIN28Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YPR161CSGV1Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1pBUR1
YJR017CESS1Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domainPIN1, PTF1